Organizational and Functional Reassignment of a Scientific Plague Control Institution of the Rospotrebnadzor under Conditions of Coronavirus Infection Pandemic

The aim of the work was to summarize the experience of the Rostov-on-Don Research Anti-Plague Institute in the organizational and functional response aimed at ensuring the implementation of a complex of on-going and scheduled anti-epidemic (preventive) measures at different territorial levels in the context of COVID-19 pandemic. Stage-wise reassignment of scientific and operational subdivisions of the facility was carried out in a timely manner in a flexible mode for a prompt response to the challenges that arose from community transmission of the new coronavirus infection in the territory of the Russian Federation. It allowed an effective distribution of the forces and assets without damage for specialized functioning in the main areas of scientific and practical activities. Realized was an effective interdepartmental interaction with territorial scientific and practical institutions of the Rospotrebnadzor and specialized medical organizations. Practical, methodological and advisory assistance was provided to personnel of specialized medical institutions within the framework of conversing in-patient facilities into hospitals for the treatment of patients with COVID-19. Priority research to study the level of the humoral and cellular immune response to SARS-CoV-2 among the population of the Rostov Region, the etiological spectrum of the causative agents of community-acquired pneumonia associated with COVID-19, full genome sequencing of SARS-CoV-2 isolates was carried out. Specialists of the task forces reinforced human resources of individual laboratory facilities in Moscow city, the Republic of Crimea and the Rostov Region. Complex objective of effective functioning has been implemented: in an operational mode – participation in anti-epidemic (preventive) measures in the face of changes in the dynamics and intensity of the epidemic manifestations of new coronavirus infection; in scheduled mode – the implementation of activities in the main areas of the scientific work of the organization

Карциносаркома предстательной железы: клинический случай

Carcinosarcoma is an exceedingly rare and highly aggressive malignant tumor. Some patients with carcinosarcoma have normal levels of prostate specific antigen; therefore, digital rectal examination is the only method of early diagnosis in them. In this article, we report a case of prostate carcinosarcoma and describe its diagnosis and treatment.Карциносаркома — крайне редкая высокоагрессивная злокачественная опухоль. У части пациентов с карциносаркомой уровень простатического специфического антигена может находиться в пределах нормальных значений, что делает пальцевое ректальное исследование единственным методом ранней диагностики этой патологии. В настоящей статье представлен клинический случай диагностики и лечения карциносаркомы предстательной железы

Features of Distribution of the Tularemia Infection in the Rostov Region

Since 1933 in the Rostov region, the official registration of tularemia began. In 1964-1949 the highest incidence was noted. Since 1947, they have been vaccinated against tularemia. In 1966 to 1973, there were no cases of tularemia. In July-August 1993, a large outbreak of tularemia (more than 200 people) was recorded. Until early 2017, the epidemic situation in tularemia in the Rostov region, according to the data of long-term monitoring, was assessed as stable, but low coverage with vaccinations against tularemia, both in the population of endemic territories and in individuals of certain professional categories was recorded. In january 2017, two residents of Rostov-on-Don received a clinical diagnosis of «tularemia». In june and july 2017, three cases of tularemia were reported. The most effective mechanism for preventing the spread of tularemia remains vaccination of the population from the contingent of risk. We consider it advisable to conduct studies of the immunity to tularemia in the population vaccinated in the last five years, to significantly increase the reliability of short- and long-term prognosis for tularemia in the region

Assessment of Population Immunity to SARS-CoV-2 Virus in the Rostov Region

By August 2020, more than 850000 cases of new coronavirus infection (COVID-19) caused by SARSCoV-2 were confirmed in the Russian Federation, with the Rostov Region as one of the ten most affected regions in Russia. The spread of the disease is largely determined by the state of population immunity in a certain area. Our research focuses on specific humoral immune response and estimates the level of herd immunity to SARS-CoV-2 virus among the population of the Rostov Region.Materials and methods. The study involved 3,048 people; the volunteers participating in the study were divided into seven age groups. The content of antibodies to SARS-CoV-2 was determined applying ELISA using a kit for the analysis of human serum or blood plasma for the presence of specific IgG to the nucleocapsid of the SARS-CoV-2 virus, manufactured by the State Scientific Center of Applied Microbiology and Biotechnology (Obolensk) in accordance with the instructions for use.Results and discussion. The assessment of seroprevalence to SARS-CoV-2 in the Rostov Region showed that the proportion of people positive for IgG to the new coronavirus was 16.5 %, the range of seropositive individuals in the general population was between 13.9 % and 19.1 % (p<0.05). There were no significant gender differences in the degree of seroprevalence with a positive result registered in 16.6 % of women and 16.5 % of men. A high level of humoral immunity to SARS-CoV-2 was established in individuals aged 1–17 against the background of low incidence rates, which may indicate the dominance of asymptomatic forms of the disease in this age group. The highest level of seropositivity was found in preschool children (33.6 %), students (29.3 %), employees (17.3 %), and education professionals (15.3 %)