PP026—Medigenia: innovative cloud based solution for pharmacovigilance

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PP179—Identification of Drug–Drug Interactions Through a Digital Health Service

e74 Volume 35 Number 8S accounting for 21.2% and 16.2% of total AED consumption (DDD 163.7 and 125.2, respectively). In the same year, oxcarbazepine and lamotrigine were the most used new AEDs (10.91% and 10.79% of total; DDD 84.1 and 83.2, respectively), while gabapentin and pregabalin exhibited the higher incidence of use. The main indication of use was epileptic disorders for older AEDs and neuropathic pain for newer AEDs. A high number of patients treated with older AEDs, in particular carbamazepine, phenobarbital, and valproic acid, received coprescription at clinically relevant interaction risk. Among newer AEDs, lamotrigine showed a high annual rate of possible interaction. Conclusion: Significant differences were shown in the prescribing pattern of newer and older medications: older AEDs were mainly used in the treatment of epileptic disorders, while newer compounds were also preferred for conditions other than epilepsy, in particular neuropathic pain. The fall in the use of newer AEDs during 2007 agreed with revised reimbursement criteria for gabapentin and pregabalin. The coprescription should be evaluated with caution and avoided if possible. Drugs at risk of interactions should be replaced with others having same indication of use. Disclosure of Interest: None declared

Ependymoblastoma. : a clinical review

Ependymoblastoma is a malignant rarely reported neuroectodermal tumor. The authors describe a further case of cerebral ependymoblastoma and examine the clinical-prognostic aspects of this tumor in the light of the published data

Medulloblastoma dell'adulto:revisione di 9 casi studiati con la RM

Medulloblastoma is a neuroectodermic, malignant tumor of the cerebellum, most commonly seen in children and accounting for 25% of all intracranial neoplasms and 33% of posterior cranial fossa neoplasms in childhood. In adulthood, medulloblastomas account for 14-30% of medulloblastomas overall and 0.4%-1% of adult brain tumors. This study reviews 9 adult patients in order to characterize the neoplasm with regard to MR features. Five patients had lateral medulloblastoma, 3 paramedian and 1 median. On long TR/long TE images medulloblastomas generally had an intermediate to hyperintense signal; on short TR/short TE images tumor had a low to intermediate signal. Enhanced MR images were heterogeneous in 8 cases, while 1 case showed no enhancement. The vermian medulloblastoma presented no diagnostic problem. Paramedian medulloblastoma often appeared infiltrative. 3 lateral medulloblastomas appeared extra-axial and nimicked other masses of the cerebellopontine angle. In our series, one feature of potential differential importance was the angiographic hypovascularity of the medulloblastomas related to the tentorium. Hydrocephalus was present in 44% of patients. Cystic and/or necrotic changes within the tumor were seen in 33%. We conclude that the MR characteristics of medulloblastomas in adulthood are variable