12 research outputs found

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    Cyclic S-N compounds and phosphorus reagents--Part XVIll<sup>1</sup>: Synthesis and X-ray structural characterization of phosphiniminocyclotrithiazenes with a primary amino substituent

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    1052-1056First examples of phosphiniminocyclotrithiazenes containing a primary amino group, (Ph)(R)(iPrNH)PN-S3N3 [R=(i) Ph. I and (ii) DCA (dicyclohexylamino), II] have been isolated from room temperature reactions of S4N4. with the corresponding phosphine in acetonitrile. Single crystal X-ray structure of compounds I and II reveal very similar endocyclic structural features, but for the deviation of tricoordinate sulphur [S(l)] from the mean plane of the ring. The primary amino group [(CH3)2CHNH]binds equally strongly in I and II, but the N-H bonds show differences in both bond length and orientation with respect to the adjacent P-N bond. Heterocycles I and II show different sensitivities for ring conversion to cyclophosphathiazene

    In-vitro dissolution rate enhancement of poorly water soluble non-steroidal antiandrogen agent, bicalutamide, with hydrophilic carriers

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    629-634This study presents dissolution rate enhancement of poorly water soluble antiandrogen agent, bicalutamide, using different solubilizing enhancers (Povidone K 30 and Poloxamer 407). Poloxamer 407 based dispersions exhibited higher dissolution ratethan Povidone K 30. Powder X-ray diffraction (PXRD) showed that degree of crystallinity decreased by increasing concentration of Povidone K 30 carrier. FTIR studies showed that drug used was compatible with carriers. Solid dispersion sprepared with povidone K30 changed crystalline form of drug to amorphous form
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