Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter.

The efficiency of shock wave lithotripsy (SWL), a noninvasive first-line therapy for millions of nephrolithiasis patients, has not improved substantially in the past two decades, especially in regard to stone clearance. Here, we report a new acoustic lens design for a contemporary electromagnetic (EM) shock wave lithotripter, based on recently acquired knowledge of the key lithotripter field characteristics that correlate with efficient and safe SWL. The new lens design addresses concomitantly three fundamental drawbacks in EM lithotripters, namely, narrow focal width, nonidealized pulse profile, and significant misalignment in acoustic focus and cavitation activities with the target stone at high output settings. Key design features and performance of the new lens were evaluated using model calculations and experimental measurements against the original lens under comparable acoustic pulse energy (E+) of 40 mJ. The -6-dB focal width of the new lens was enhanced from 7.4 to 11 mm at this energy level, and peak pressure (41 MPa) and maximum cavitation activity were both realigned to be within 5 mm of the lithotripter focus. Stone comminution produced by the new lens was either statistically improved or similar to that of the original lens under various in vitro test conditions and was significantly improved in vivo in a swine model (89% vs. 54%, P = 0.01), and tissue injury was minimal using a clinical treatment protocol. The general principle and associated techniques described in this work can be applied to design improvement of all EM lithotripters

How to use magnetic field information for coronal loop identification?

The structure of the solar corona is dominated by the magnetic field because the magnetic pressure is about four orders of magnitude higher than the plasma pressure. Due to the high conductivity the emitting coronal plasma (visible e.g. in SOHO/EIT) outlines the magnetic field lines. The gradient of the emitting plasma structures is significantly lower parallel to the magnetic field lines than in the perpendicular direction. Consequently information regarding the coronal magnetic field can be used for the interpretation of coronal plasma structures. We extrapolate the coronal magnetic field from photospheric magnetic field measurements into the corona. The extrapolation method depends on assumptions regarding coronal currents, e.g. potential fields (current free) or force-free fields (current parallel to magnetic field). As a next step we project the reconstructed 3D magnetic field lines on an EIT-image and compare with the emitting plasma structures. Coronal loops are identified as closed magnetic field lines with a high emissivity in EIT and a small gradient of the emissivity along the magnetic field.Comment: 14 pages, 3 figure