Muons with E_th >= 1 Gev and Mass Composition in the Energy Range 10^{18}-10^{20} ev Observed by Yakutsk Eas Array

The ratio of the muon flux density to charged particle flux density at distances of 300 and 600 m from the shower axis (\rhom(300)/\rhos(300) and \rhom(600)/\rhos(600)) is measured. In addition, the energy dependence of \rhom(1000) is analysed for showers with energies above $10^{18}$ eV. A comparison between the experimental data and calculations performed with the QGSJET model is given for the cases of primary proton, iron nucleus and gamma- ray. We conclude that the showers with \E\ge3\times10^{18} eV can be formed by light nuclei with a pronounced fraction of protons and helium nuclei. It is not excluded however that a small part of showers with energies above $10^{19}$ eV could be initiated by primary gamma-rays.Comment: 19th European Cosmic Ray Symposium, Aug 30 - Sep 3 2004, Florence, Italy. 3 pages, 1 figure. Submitted for publication in International Journal of Modern Physics

ЭПИДЕМИОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА ПАРЕНТЕРАЛЬНЫХ ВИРУСНЫХ ГЕПАТИТОВ СРЕДИ ОЛЕНЕВОДОВ-КОЧЕВНИКОВ В ЮЖНОЙ ЯКУТИИ

Researches of parenteral viral hepatitis prevalence in Republic of Sakha (Yakutia) showed high frequency of hepatitis B and C infection markers. High level of HBsAg carriage among indigenous nationalities representatives living in isolated ethnic group had been revealed (12,9%). HBsAg and anti-HBc detection frequencies is 12,9% and 76,0% respectively in comparison with 5,8% and 14,6% among newcomer population (p<0,001). In spreading of HBV-infection leading role belong to natural ways which prevalence in majority of age groups. This fact causes necessity of prevention measures correction. Among newcomer population, we can note high level of HCV infection. Results of parenteral viral hepatitis epidemiological distinguishes evaluation among indigenous nationalities in Southern Yakutia shows to necessity of medical care system improvement and special medical programs. To reason that measures we have to perform complex screening researches to parenteral viral hepatitis infection markers.Изучение распространения парентеральных вирусных гепатитов в Республике Саха (Якутия) показало высокую частоту выявления маркеров инфицирования вирусами гепатитов В и С. Установлен высокий уровень носительства HBsAg у лиц коренной национальности (12,9%), проживающих изолированной этнической группой. Частота выявления HBsAg и анти-НВс в обследованной группе эвенков составила 12,9% и 76,0% соответственно по сравнению с 5,8% и 14,6% соответственно среди некоренного населения (p<0,001). В распространении ВГВ-инфекции ведущее место принадлежит естественным путям передачи; они преобладают в большинстве возрастных групп, что обусловливает необходимость коррекции проводимых профилактических и противоэпидемических мероприятий. Среди пришлого населения отмечается высокий уровень заболеваемости гепатитом С. Результаты оценки эпидемиологических особенностей парентеральных вирусных гепатитов среди коренного населения Южной Якутии указывают на необходимость улучшения системы обеспечения качественной медицинской помощью данной группы населения и разработки специальных лечебно-профилактических программ. Для обоснования данных мероприятий в регионе необходимо проводить комплексные мониторинговые исследования на маркеры инфицирования парентеральными вирусными гепатитами

A single blind, placebo-controlled randomized study of the safety, reactogenicity and immunogenicity of the “EpiVacCorona” Vaccine for the prevention of COVID-19, in volunteers aged 18–60 years (phase I–II)

Vaccination of the population is one of the most effective countermeasures in responding to the pandemic caused by novel coronavirus infection. Therefore, scientists all over the world have been working to develop effective and safe vaccines. We have developed a synthetic peptide vaccine, EpiVacCorona, against novel SARS-CoV-2 coronavirus, which is a suspension for intramuscular administration containing a composition of chemically synthesized peptide immunogens of the S protein of SARS-CoV-2 coronavirus conjugated to a carrier protein and adsorbed on aluminum hydroxide. Phase I–II clinical trials of the vaccine have started that consist of two stages: Stage 1 is an open study of the safety, reactogenicity, and immunological activity of the vaccine with the involvement of 14 volunteers aged 18–30 years; Stage 2 is a single blind, comparative, randomized placebo-controlled study with the involvement of 86 volunteers. The study involved volunteers aged 18–60 years; the vaccine was injected intramuscularly twice, spaced 21 days apart between injections. All local reactions in response to vaccine administration were mild, such as a short-term pain at the injection site. There were no signs of development of local or systemic adverse reactions. The two-dose vaccination scheme induced the production of antibodies, specific to the antigens that make up the vaccine, in 100% of the volunteers. Seroconversion with a neutralizing antibody titer ≥ 1:20 was reported in 100% of the volunteers 21 days following the second immunization dose. No seroconversion was reported in the groups of volunteers vaccinated with a placebo. The peptide-based EpiVacCorona Vaccine has low reactogenicity and is a safe, immunogenic product. Clinical Trials Identifier: NCT04527575

EPIDEMIOLOGICAL CHARACTERISTICS OF PARENTERAL VIRAL HEPATITIS AMONG REINDEER HERDERS IN SOUTH YAKUTIA

Researches of parenteral viral hepatitis prevalence in Republic of Sakha (Yakutia) showed high frequency of hepatitis B and C infection markers. High level of HBsAg carriage among indigenous nationalities representatives living in isolated ethnic group had been revealed (12,9%). HBsAg and anti-HBc detection frequencies is 12,9% and 76,0% respectively in comparison with 5,8% and 14,6% among newcomer population (p<0,001). In spreading of HBV-infection leading role belong to natural ways which prevalence in majority of age groups. This fact causes necessity of prevention measures correction. Among newcomer population, we can note high level of HCV infection. Results of parenteral viral hepatitis epidemiological distinguishes evaluation among indigenous nationalities in Southern Yakutia shows to necessity of medical care system improvement and special medical programs. To reason that measures we have to perform complex screening researches to parenteral viral hepatitis infection markers