Реконструкция развития соляных структур Верхнекамского месторождения солей

The article highlights some issues of geology and genesis of structural forms of the Verkhnekamskoye Salt Deposit (Perm krai). On the example of the Popovskiy salt dome location, the results of detailed studies and analysis of data on the geological structure of sedimentary strata and their morphology are presented. The reconstruction of the evolution of salt structures, the uplifts and depressions was carried out. The main factors and mechanisms, which controlled the development of a modern tectonic structure of this territory, were determined. Significant role in formation of the modern tectonic features of the upper part of the sedimentary cover played the accumulation in the Kungurian age of the Permian the ductile salt rocks, which, at the Late Paleozoic - Early Mesozoic subsequent stages of the territory evolution, determined the increased tectonic mobility of salt and supra-salt deposits, and the formation of high-amplitude uplifts and basins. Differences in tectonogenesis of the upper part of the sedimentary cover, comprising the ductile salt-bearing strata and the underlying rigid rocks, led to the division of the sedimentary cover of the Solikamskaya depression of the Cis-Ural trough into two tectonic stages. The lower level includes uplifts representing the draping structures of the Fransian-Tournaisian reef massifs and brachianticline folds of longitudinal compression, and the upper level comptises the structures formed as a result of the halokinesis of plastic rocks.Освещаются вопросы геологии и генезиса структурных форм Верхнекамского месторождения солей (Пермский край). На примере участка месторождения, где расположен Поповский соляной купол, приведены результаты детальных исследований и анализа данных о геологическом строении осадочных толщ, их морфологии. Проведена реконструкция развития соляных структур – поднятий и впадин. Определены основные факторы и механизмы, под влиянием которых описываемая территория приобрела современное тектоническое строение. Большое значение в формировании современного тектонического облика верхней части осадочного чехла имело накопление в кунгурский век пермского периода толщи солей – податливых пород, что на последующих этапах развития территории (поздний палеозой – ранний мезозой) определило повышенную тектоническую подвижность соляных и надсоляных отложений, формирование высокоамплитудных поднятий и впадин. Различный тектогенез верхней части осадочного чехла, включающей соленосную толщу, и нижезалегающих жестких пород обусловил разделение осадочного чехла Соликамской впадины Предуральского прогиба на два тектонических этажа. Нижний этаж включает поднятия, представляющие структуры облекания франско-турнейских рифогенных массивов и брахискладки продольного сжатия, верхний – структуры, сформированные в результате галокинеза пластичных масс

Анализ групповой вспышки трихинеллеза у подростков в Самарской области

Objective. To study the peculiarities of trichinosis on the material of the group flashes.Materials and methods. Described and analyzed outbreak of trichinosis in 14 adolescents aged 13 to 18 years, were hospitalized in pediatric infectious ward of the city of Samara.Results. The source of infection – infected meat badger. The severity of illness depend on the amount of meat eaten, that is, the infectious dose of the pathogen. In severe cases, the incubation period of trichinosis was minimal (7 days), and if less severe – the maximum (from 19,5 to 21 days). Mild course also contributed to the early administration of antiparasitic therapy. Most of the children the disease begins with fever and dyspepsia, half recorded rash.At the height of the disease is predominant myalgias, half of cases – swelling. The peculiarity of the current severe trichinosis were pronounced toxic-allergic syndrome, generalized edema, myalgia and myasthenia gravis, up to a full adinamii, organ destruction: infectious-toxic kidney, cardiomyopathy, fulminant hepatitis, polyserositis with ascites, hydrothorax 3 weekdisease. The temperature in most of the patients wore a doublewavelength character with rises in the disease onset and disease for 2–3 weeks. It noted the duration of the clinical symptoms. The longest was myalgic, half of the patients remained at the time of discharge from the hospital. The features of laboratory parameters (leukocytosis, eosinophilia, ALT, AST, CRP) in various forms of the disease. The diagnosis was confirmed by serology (IgM, Ig G to Trichinella spiralis) in different phases of the disease. All patients received a specific antiparasitic therapy albendazolom secondary therapeutic dosage for 10 days, as well as detoxication, allergen and symptomatic therapy is indicated.Conclusion. Thus, health education among the population and will be a true prevention of trichinosis.Цель. Изучить особенности течения трихинеллеза на материале групповой вспышки.Материалы и методы. Описана и проанализирована вспышка трихинеллеза у 14 подростков в возрасте от 13 до 18 лет, находившихся на стационарном лечении в детском инфекционном отделении больницы города Самары.Результаты. Источник инфекции – зараженное мясо барсука. Тяжесть заболевания зависела от количества съеденного мяса, то есть от инфицирующей дозы возбудителя. В случае тяжелой формы трихинеллеза инкубационный период был минимальным (7 дней), при легкой – максимальным (от 19,5 до 21 дня). Развитию легкой формы способствовало раннее назначение антипаразитарной терапии. У большинства детей заболевание начиналось с лихорадки и диспепсических явлений, у половины регистрировалась экзантема. В разгаре заболевания преобладающими являлись миалгии, у половины заболевших детей – отеки. Особенностью течения тяжелой формы трихинеллеза явились выраженный токсико-аллергический синдром, генерализованные отеки, миалгии и миастении, вплоть до полной адинамии, органные поражения: инфекционно-токсическая почка, кардиомиопатия, реактивный гепатит, полисерозит с асцитом, гидротораксом на 3-й неделе заболевания. Температура у большей части больных носила двухволновый характер с подъемами в дебюте заболевания и на 2–3-й неделе заболевания. Отмечена продолжительность клинических симптомов. Самым продолжительным был миалгический, у половины больных сохранялся к моменту выписки из стационара. Отмечены особенности лабораторных показателей (лейкоцитоз, эозинофилия, АЛАТ, АСАТ, СРБ) при различных формах заболевания. Диагноз подтверждался серологически (IgM, Ig G к Trichinella spiralis) в различные фазы заболевания. Все больные получали специфическую антипаразитарную терапию альбендазолом в средне-терапевтической дозировке в течение 10 дней, а также дезинтоксикационную, гипосенсибилизирующую и симптоматическую терапию по показаниям.Заключение. Проведение санитарно-просветительской работы среди населения актуально и будет являться профилактикой возникновения трихинеллез

Tectonics of the Junction of the East European Platform and the Solikamsk Depression within the Pre-Urals Foredeep

Comparison of the geological structure of sedimentary cover of the eastern part of the East-European Platform and the Solikamsk Depression within the Pre-Urals Foredeep Basin was carried out. It is shown that halogen and clastic formations of this basin have lower mechanical properties compared to surrounding carbonate strata. Because of the horizontal compressive stress, the asymmetric plastic body formed by these rocks experienced intensive deformations. It is shown that the tectonic influence of the Urals extends through the Solikamsk Depression to the western edge of the Pre-Urals Foredeep basin

Analysis of biological and genetic stability of tick-borne encephalitis strain 205 used in the production of tick-borne encephalitis vaccines EnceVir and EnceVir Neo for children

The article presents the results of a long-term study of biological and genetic stability of tick-borne encephalitis strain 205 which is used by the FSUE «SPA «Microgen» to produce tick-borne encephalitis vaccines EnceVir (for adults) and EnceVir Neo for children, both of which are tissue cultured, inactivated, purified, and sorbed. The biological stability of strain 205 was studied at the seed lot stage using passages on outbred white mice: initial production strain 205 and production «stock strain». Lyophilisates of production seed lots were studied at different storage intervals at -20 °С (up to 9 years of storage and more). Biological activity parameters (tick-borne encephalitis virus (TBEV) titre in log LD50/ml) were studied by using different ways of infecting outbred white mice, and strain 205 identification (specificity) was determined by comparing it to a reference strain in a biological neutralization assay (BNA) according to the manufacturer’s specifications for the vaccines concerned. The same materials and a batch of TBEV vaccine produced from the production «stock strain» (lyophilisate of 1986) were analyzed by polymerase chain reaction (PCR) and sequencing for genetic stability during passaging and long-term storage. The results of the study made it possible to demonstrate the biological and genetic stability of strain 205 during production of TBEV vaccines

Analysis Group outbreak of trichinosis in adolescents in the Samara region

Objective. To study the peculiarities of trichinosis on the material of the group flashes.Materials and methods. Described and analyzed outbreak of trichinosis in 14 adolescents aged 13 to 18 years, were hospitalized in pediatric infectious ward of the city of Samara.Results. The source of infection – infected meat badger. The severity of illness depend on the amount of meat eaten, that is, the infectious dose of the pathogen. In severe cases, the incubation period of trichinosis was minimal (7 days), and if less severe – the maximum (from 19,5 to 21 days). Mild course also contributed to the early administration of antiparasitic therapy. Most of the children the disease begins with fever and dyspepsia, half recorded rash.At the height of the disease is predominant myalgias, half of cases – swelling. The peculiarity of the current severe trichinosis were pronounced toxic-allergic syndrome, generalized edema, myalgia and myasthenia gravis, up to a full adinamii, organ destruction: infectious-toxic kidney, cardiomyopathy, fulminant hepatitis, polyserositis with ascites, hydrothorax 3 weekdisease. The temperature in most of the patients wore a doublewavelength character with rises in the disease onset and disease for 2–3 weeks. It noted the duration of the clinical symptoms. The longest was myalgic, half of the patients remained at the time of discharge from the hospital. The features of laboratory parameters (leukocytosis, eosinophilia, ALT, AST, CRP) in various forms of the disease. The diagnosis was confirmed by serology (IgM, Ig G to Trichinella spiralis) in different phases of the disease. All patients received a specific antiparasitic therapy albendazolom secondary therapeutic dosage for 10 days, as well as detoxication, allergen and symptomatic therapy is indicated.Conclusion. Thus, health education among the population and will be a true prevention of trichinosis

Integrated stratigraphy of the Bartonian-Priabonian Urtsadzor section, Armenia

The uppermost Bartonian to lowermost Priabonian transition is associated with several rapid extinctions across microfossil groups. However, the marker for the Bartonian-Priabonian boundary is not formally defined and currently under discussion. The planktonic foraminifera Acarinina and Morozovelloides suffer a rapid global extinction and calcareous nannofossils show several assemblage changes including the last occurrences of Sphenolithus obtusus and Chiasmolithus grandis, the acme of Cribrocentrum erbae and first occurrences of Chiasmolithus oamaruensis, Isthmolithus recurvus and Cribrocentrum isabellae around this interval. Within the shallow water, larger foraminifera also show an extinction of the large species of the genus Nummulites, as well as the first occurrences of important genera, such as Spiroclypeus and Pellatispira the upper middle Eocene. However, the exact correlation between shallow and deep water records remains uncertain, as do the mechanisms driving these extinction events. Here we present the first results of a new integrated stratigraphical study (calcareous nannofossils, planktonic foraminifera, larger benthic foraminifera, and magnetostratigraphy) of the Urtsadzor section in south-western Armenia which appears to be continuous through this interval. The Urtsadzor section consists of marlstones rich in micro- and nannofossils, with interbedded limestones containing abundant larger foraminifera. Our new data enable us to correlate larger foraminiferal events with global planktonic biostratigraphy, in a section outside of southwest Europe where most previous correlations have been based. At Urtsadzor, the large Nummulites species N. millecaput, appear to decrease in abundance toward the top of the section. The first occurrence of Spiroclypeus occurs in the uppermost limestone bed. These larger foraminiferal events occur well above the planktonic foraminiferal extinction level and nannofossil assemblage changes indicating the event is not synchronous across all groups, and has important implications for biostratigraphy