Synthesis and study of the antimicrobial activity of nifuroxazide derivatives

The number of infections caused by microorganisms that are resistant to antibiotics and synthetic antibacterial drugs is growing fast worldwide. This is one of the most important and urgent problems in health care. The main efforts of researchers around the world are focused on solving this issue. Nitrofurans represent one of the most effective classes of antibacterial drugs. We have synthesized 4 analogues of nifuroxazide – a well known nitrofuran antibiotic – and confirmed their structures by NMR, IR spectroscopy, and mass-spectrometry. All of the obtained compounds were studied for antimicrobial and antifungal activity. Activity against Escherichia coli, Staphylococcus aureus, Staphylococcus haemolyticus, and Pseudomonas aeruginosa was evaluated by the agar diffusion method. The synthesized compounds suppressed the growth of all the studied bacterial strains except Escherichia coli; the diameter of the inhibition zones ranged from 13.5 to 28 mm depending on the concentration of the tested compound and bacterial strain. One of the compounds studied in this project – the pyridine analogue of nifuroxazide – exceeded the activity of the standard (nifuroxazide) against the Staphylococcus aureus. The inhibitory activity of the synthesized compounds against the Candida albicans and Cryptococcus neoformans yeasts was determined using the microdilution method. The results were assessed according to the indicator color change. None of the studied compounds showed activity against these cultures. The obtained results confirm that substituted nifuroxazides have significant antimicrobial activity and, therefore, can be considered as promising candidates for developing new antibacterial drugs.The number of infections caused by microorganisms that are resistant to antibiotics and synthetic antibacterial drugs is growing fast worldwide. This is one of the most important and urgent problems in health care. The main efforts of researchers around the world are focused on solving this issue. Nitrofurans represent one of the most effective classes of antibacterial drugs. We have synthesized 4 analogues of nifuroxazide – a well known nitrofuran antibiotic – and confirmed their structures by NMR, IR spectroscopy, and mass-spectrometry. All of the obtained compounds were studied for antimicrobial and antifungal activity. Activity against Escherichia coli, Staphylococcus aureus, Staphylococcus haemolyticus, and Pseudomonas aeruginosa was evaluated by the agar diffusion method. The synthesized compounds suppressed the growth of all the studied bacterial strains except Escherichia coli; the diameter of the inhibition zones ranged from 13.5 to 28 mm depending on the concentration of the tested compound and bacterial strain. One of the compounds studied in this project – the pyridine analogue of nifuroxazide – exceeded the activity of the standard (nifuroxazide) against the Staphylococcus aureus. The inhibitory activity of the synthesized compounds against the Candida albicans and Cryptococcus neoformans yeasts was determined using the microdilution method. The results were assessed according to the indicator color change. None of the studied compounds showed activity against these cultures. The obtained results confirm that substituted nifuroxazides have significant antimicrobial activity and, therefore, can be considered as promising candidates for developing new antibacterial drugs

Computing Garsia Entropy for Bernoulli Convolutions with Algebraic Parameters

We introduce a parameter space containing all algebraic integers $\beta\in(1,2]$ that are not Pisot or Salem numbers, and a sequence of increasing piecewise continuous function on this parameter space which gives a lower bound for the Garsia entropy of the Bernoulli convolution $\nu_{\beta}$. This allows us to show that $\mathrm{dim}_\mathrm{H} (\nu_{\beta})=1$ for all $\beta$ with representations in certain open regions of the parameter space.Comment: 21 pages, 2 figures, 5 table

Orientational Order-Disorder Effects in Molecular Crystals as Evidenced by Low-Frequency Raman Spectra

The studies of reorientational motions of molecules in crystals of organic compounds by low-frequency Raman spectroscopy are briefly reported. Some examples illustrate the efficiency of the investigation of order-disorder phenomena in organic crystals by the temperature dependence of low-frequency vibrational spectra combined with simultaneous calculations of the molecular dynamics by the atom-atom potentials (AAP) method. The conditions have been determined which are necessary in order to affect the low-frequency Raman spectra by anisotropy of molecular reorientations in crystals

Incoherent pion photoproduction on the deuteron in the first resonance region

Incoherent pion photoproduction on the deuteron is studied in the first resonance region. The unpolarized cross section, the beam asymmetry, and the vector and tensor target asymmetries are calculated in the framework of a diagrammatic approach. Pole diagrams and one-loop diagrams with $NN$ scattering in the final state are taken into account. An elementary operator for pion photoproduction on the nucleon is taken in various on-shell forms and calculated using the SAID and MAID multipole analyses. Model dependence of the obtained results is discussed in some detail. A comparison with predictions of other works is given. Although a reasonable description of many available experimental data on the unpolarized total and differential cross sections and photon asymmetry has been achieved, in some cases a significant disagreement between the theory and experiment has been found. Invoking known information on the reactions $\gamma d\to\pi^0 d$ and $\gamma d\to np$ we predict the total photoabsorption cross section for deuterium. We find that our values strongly overestimate experimental data in the vicinity of the $\Delta$ peak.Comment: 22 pages, 23 figure

Polyoxometalate chemistry at volcanoes: discovery of a novel class of polyoxocuprate nanoclusters in fumarolic minerals

Polyoxometalate (POM) chemistry is an important avenue of comprehensive chemical research, due to the broad chemical, topological and structural variations of multinuclear polyoxoanions that result in advanced functionality of their derivatives. The majority of compounds in the polyoxometalate kingdom are synthesized under laboratory conditions. However, Nature has its own labs with the conditions often unconceivable to the mankind. The striking example of such a unique environment is volcanic fumaroles – the natural factories of gas-transport synthesis. We herein report on the discovery of a novel class of complex polyoxocuprates grown in the hot active fumaroles of the Tolbachik volcano at the Kamchatka Peninsula, Russia. The cuboctahedral nanoclusters {[MCu$_{12}$O$_{8}$](AsO$_{4}$)$_{8}$} are stabilized by the core Fe(III) or Ti(IV) cations residing in the unique cubic coordination. The nanoclusters are uniformly dispersed over the anion- and cation-deficient NaCl matrix. Our discovery might have promising implications for synthetic chemistry, indicating the possibility of preparation of complex polyoxocuprates by chemical vapor transport (CVT) techniques that emulate formation of minerals in high-temperature volcanic fumaroles

Invariant Sets and Explicit Solutions to a Third-Order Model for the Shearless Stratified Turbulent Flow

We study dynamics of the shearless stratified turbulent flows. Using the method of differential constraints we find a class of explicit solutions to the problem under consideration and establish that the differential constraint obtained coincides with the well-known Zeman--Lumley model for stratified flows.Comment: arxiv version is already officia

Some properties of WKB series

We investigate some properties of the WKB series for arbitrary analytic potentials and then specifically for potentials $x^N$ ($N$ even), where more explicit formulae for the WKB terms are derived. Our main new results are: (i) We find the explicit functional form for the general WKB terms $\sigma_k'$, where one has only to solve a general recursion relation for the rational coefficients. (ii) We give a systematic algorithm for a dramatic simplification of the integrated WKB terms $\oint \sigma_k'dx$ that enter the energy eigenvalue equation. (iii) We derive almost explicit formulae for the WKB terms for the energy eigenvalues of the homogeneous power law potentials $V(x) = x^N$, where $N$ is even. In particular, we obtain effective algorithms to compute and reduce the terms of these series.Comment: 18 pages, submitted to Journal of Physics A: Mathematical and Genera