A rare combination of an endocrine tumour of the common bile duct and a follicular lymphoma of the ampulla of Vater: a case report and review of the literature

Carcinoid tumours of the common bile duct represent an extremely rare entity. Similarly, primary follicular lymphomas of the ampulla of Vater constitute an infrequent neoplasia. Herein, we report the first case of a synchronous development of a carcinoid tumour of the common bile duct and an ampullary follicular lymphoma that was treated surgically with a Whipple's procedure, due to inability to establish definitive preoperative diagnosis despite the extensive diagnostic investigation

Text line and word segmentation of handwritten documents

In this paper, we present a segmentation methodology of handwritten documents in their distinct entities, namely, text lines and words. Text line segmentation is achieved by applying Hough transform on a subset of the document image connected components. A post-processing step includes the correction of possible false alarms, the detection of text lines that Hough transform failed to create and finally the efficient separation of vertically connected characters using a novel method based on skeletonization. Word segmentation is addressed as a two class problem. The distances between adjacent overlapped components in a text line are calculated using the combination of two distance metrics and each of them is categorized either as an inter- or an intra-word distance in a Gaussian mixture modeling framework. The performance of the proposed methodology is based on a consistent and concrete evaluation methodology that uses suitable performance measures in order to compare the text line segmentation and word segmentation results against the corresponding ground truth annotation. The efficiency of the proposed methodology is demonstrated by experimentation conducted on two different datasets: (a) on the test set of the ICDAR2007 handwriting segmentation competition and (b) on a set of historical handwritten documents. © 2009 Elsevier Ltd. All rights reserved

Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State

Hypercholesterolemia has previously been induced in the mouse by a single intravenous injection of adeno-associated virus (AAV)-based vector harboring gain-of-function pro-protein convertase subtilisin/kexin type 9. Despite the recent emergence of the PCSK9-AAV model, the profile of hematological and coagulation parameters associated with it has yet to be characterized. We injected 1.0 × 1011 viral particles of mPCSK9-AAV or control AAV into juvenile male C57BL/6N mice and fed them with either a Western-type high-fat diet (HFD) or standard diet over the course of 3 weeks. mPCSK9-AAV mice on HFD exhibited greater plasma PCSK9 concentration and lower low-density lipoprotein levels, concomitant with increased total cholesterol and non-high-density lipoprotein (non-HDL)-cholesterol concentrations, and lower HDL-cholesterol concentrations than control mice. Furthermore, mPCSK9-AAV-injected mice on HFD exhibited no signs of atherosclerosis at 3 weeks after the AAV injection. Hypercholesterolemia was associated with a thromboinflammatory phenotype, as neutrophil levels, monocyte levels, and neutrophil-to-lymphocyte ratios were higher and activated partial thromboplastin times (aPTTs) was lower in HFD-fed mPCSK9-AAV mice. Therefore, the mPCSK9-AAV is a suitable model of hypercholesterolemia to examine the role of thromboinflammatory processes in the pathogenesis of cardiovascular and cerebrovascular diseases