Immune Response in Ovarian Cancer: How Is the Immune System Involved in Prognosis and Therapy: Potential for Treatment Utilization

Ovarian cancer is one of the leading causes of cancer-related death among women. Resistance to the disease occurs in more than 70% of the cases even after treated with chemotherapy agents such as paclitaxel- and platinum-based agents. The immune system is increasingly becoming a target for intense research in order to study the host's immune response against ovarian cancer. T cell populations, including NK T cells and Tregs, and cytokines have been associated with disease outcome, indicating their increasing clinical significance, having been associated with prognosis and as markers of disease progress, respectively. Harnessing the immune system capacity in order to induce antitumor response remains a major challenge. This paper examines the recent developments in our understanding of the mechanisms of development of the immune response in ovarian cancer as well as its prognostic significance and the existing experience in clinical studies

A multi-proxy approach for reconstructing environmental dynamics since the mid Holocene in Lake Ismarida (Thrace, N. Greece)

The paleoenvironmental evolution of Lake Ismarida in Thrace (Northern Greece) is revealed by the combined lithological, micropaleontological (benthic foraminifera, pollen and NPPS), molluscan analyses, magnetic susceptibility measurement and radiocarbon dating of a 5.8-m long sediment core. The mid Holocene evolution of the lake area is evidenced by the documentation of four sedimentary Units in the core ISMR-2, corresponding to four distinct evolutionary stages: (1) during ∼5500-3500 cal yr BP the lake area was a shallow marine environment characterized by an Ammonia beccarii, small rotaliids, miliolids, Bittium reticulatum and Veneridae spp. assemblage, marine dinoflagellate cysts, and low magnetic susceptibility values; (2) during ∼3500-3000 cal BP the environment is gradually tending to more isolated conditions forming an open lagoon, characterized by marine and euryhaline fauna and low magnetic susceptibility values; (3) during 3000 cal yr BP, the open lagoon presented a transition to an oligohaline inner lagoon, characterized by an Ammonia tepida, Haynesina germanica, Aubignyna perlucida, Pirenella conica, Cerastoderma glaucum and Abra spp. assemblage, sedges and aquatic vegetation. This restricted, entirely isolated from the sea inner lagoon could be definitely used as the landmark of the Lake Ismaris from Heorodotus, while describing the march of Xerxes through Thrace in 480 B.C.; (4) since ∼2000 cal yr BP to the present, the Lake Ismarida is formed, characterized by fresh-water indicators and aquatic pollen, Pseudoschizaea and high magnetic susceptibility values. Finally, the progradation of the Filiouris River deltaic deposits resulted to a 4 km wide deltaic plain between Lake Ismarida and the nowadays coastline. Pollen assemblages record the dominance of a rather rich deciduous forest in the area with traces of human presence in the lower part of the sequence, whereas the opening of the plant landscape under the increasing human pressure is evidenced after ∼ 3000 cal yr BP. Finally, an open vegetation pattern, contemporaneous with the retreat of forest vegetation, is evidenced in the area already before 2000 cal yr BP. © 2020 Elsevier Masson SA

Prechemotherapy serum levels of CD105, transforming growth factor β2, and vascular endothelial growth factor are associated with prognosis in patients with advanced epithelial ovarian cancer treated with cytoreductive surgery and platinum-based chemotherapy

Background: Serum CD105 has been associated with angiogenic activity in cancer, and low CD105 expression has been associated with improved prognosis. The present study evaluated the prognostic significance of serum levels of CD105 and related factors in patients with epithelial ovarian cancer (EOC) after cytoreductive surgery and chemotherapy. Patients and Methods: Eighty-six patients with stages IIC to IV EOC treated postoperatively with platinum-based chemotherapy were included. The enzyme-linked immunosorbent assay was used to measure prechemotherapy serum levels of CD105, transforming growth factor β1/2 (TGF-β1/2), angiopoietin 2, vascular endothelial growth factor, and tumor necrosis factor-α. Results: High levels of TGF-β2 (≥8908.86 pg/mL) and CD105 (≥4.25 ng/mL) were independently associated with improved overall survival (not reached vs 39 months, P = 0.009 and 75 vs 39 months, P = 0.029, respectively), whereas a high level of TGF-β2 and a low level of vascular endothelial growth factor (<219.04 pg/mL) were independently associated with improved progression-free survival (49 vs 17 months, P = 0.022 and 57 vs 16 months, P = 0.023, respectively). Among patients with favorable (≥4.25 ng/mL) CD105 levels, only patients with low TGF-β1 levels (<177.1 ng/mL) had superior survival than patients with low CD105 levels. Conclusions: Our study confirms the prognostic significance of angiogenesis in EOC and supports a biological interaction between CD105 and TGF-β1. High angiogenic activity may be associated by increased efficacy of postoperative chemotherapy. Copyright© 2010 by IGCS and ESGO