Constraints on Warm Dark Matter from Cosmological Reionization

We study the constraints that high-redshift structure formation in the universe places on warm dark matter (WDM) dominated cosmological models. We modify the extended Press-Schechter formalism to derive the halo mass function in WDM models. We show that our predictions agree with recent numerical simulations at low redshift over the halo masses of interest. Applying our model to galaxy formation at high redshift, we find that the loss of power on small scales, together with the delayed collapse of low-mass objects, results in strong limits on the root-mean-square velocity dispersion v_rms of the WDM particles at z=0. For fermions decoupling while relativistic, these limits are equivalent to constraints on the mass m_X of the particles. The presence of a 4 billion solar mass black hole at z=5.8, believed to power the quasar SDSS 1044-1215, implies m_X > 0.5 keV (or v_rms < 0.10 km/s), assuming that the quasar is unlensed and radiating at or below the Eddington limit. Reionization by z=5.8 also implies a limit on m_X. If high-redshift galaxies produce ionizing photons with an efficiency similar to their z=3 counterparts, we find m_X > 1.2 keV (or v_rms < 0.03 km/s). However, given the uncertainties in current measurements from the proximity effect of the ionizing background at redshift 3, values of m_X as low as 0.75 keV (v_rms = 0.06 km/s) are not ruled out. The limit weakens further if, instead, the ionizing-photon production efficiency is greater at high z, but this limit will tighten considerably if reionization is shown in the future to have occurred at higher redshifts. WDM models with m_X 0.04 km/s) produce a low-luminosity cutoff in the high-redshift galaxy luminosity function which is directly detectable with the Next Generation Space Telescope (abridged).Comment: 38 pages, 10 figures, to appear in ApJ. One figure added, some discussion revise

Response and Recovery of the Comanche Carbonate Platform Surrounding Multiple Cretaceous Oceanic Anoxic Events, Northern Gulf of Mexico

The ubiquity of carbonate platforms throughout the Cretaceous Period is recognized as a product of high eustatic sea-level and a distinct climatic optimum induced by rapid sea-floor spreading and elevated levels of atmospheric carbon-dioxide. Notably, a series of global oceanic anoxic events (OAEs) punctuate this time-interval and mark periods of significantly reduced free oxygen in the world's oceans. The best records of these events are often from one-dimensional shelf or basin sections where only abrupt shifts between oxygenated carbonates and anoxic shales are recorded. The Comanche Platform of central Texas provides a unique opportunity to study these events within a well-constrained stratigraphic framework in which their up-dip and down-dip sedimentologic effects can be observed and the recovery of the platform to equilibrium states can be timed and understood. Stable isotope data from whole cores in middle Hauterivian through lower Campanian mixed carbonate-siliciclastic strata are used to construct a 52-myr carbon isotope reference profile for the northern Gulf of Mexico. Correlation of this composite curve to numerous global reference profiles permits identification of several anoxic events and allows their impact on platform architecture and fades distribution to be documented. Oceanic anoxic events la, 1b, 1d, and 2 occurred immediately before, after, or during shale deposition in the Pine Island Member, Bexar Member, Del Rio Formation, and Eagle Ford Group, respectively. Oceanic anoxic event 3 corresponds to deposition of the Austin Chalk Group. Platform drowning on three occasions more closely coincided with globally recognized anoxic sub-events such as the Fallot, Albian-Cenomanian, and Mid-Cenomanian events. This illustrates that the specific anoxic event most affecting a given carbonate platform varied globally as a function of regional oceanographic circumstances. Using chemo- and sequence-stratigraphic observations, a four-stage model is proposed to describe the changing fades patterns, fauna, sedimentation accumulation rates, platform architectures, and relative sea-level trends of transgressive-regressive composite sequences that developed in response to global carbon-cycle perturbations. The four phases of platform evolution include the equilibrium, crisis, anoxic, and recovery stages. The equilibrium stage is characterized by progradational shelf geometries and coralrudist phototrophic faunal assemblages. Similar phototrophic fauna typify the crisis stage; however, incipient biocalcification crises of this phase led to retrogradational shelf morphologies, transgressive facies patterns, and increased clay mineral proportions. Anoxic stages of the Comanche Platform were coincident with back-ground deposition of organic-rich shale on drowned shelves and heterotrophic fauna dominated by oysters or coccolithophorids. Eustatic peaks of this stage were of moderate amplitude (similar to 30 m), yet relative sea-level rises were greatly enhanced by reduced sedimentation rates. In the recovery stage, heterotrophic carbonate factories re-established at the shoreline as progradational ramp systems and sediment accumulation rates slowly increased as dysoxia diminished. Full recovery to equilibrium conditions may or may not have followed. Geochemical and stratigraphic trends present in the four stages are consistent with increased volcanism along mid-ocean ridges and in large-igneous provinces as primary drivers of Cretaceous OAEs and the resulting transgressive-regressive composite sequences. (C) 2014 Elsevier Ltd. All rights reserved.BHP-BillitonReservoir Characterization Research Laboratory, the Bureau of Economic GeologyJackson School of Geosciences at the University of Texas at AustinBureau of Economic Geolog

MORPHOLOGY AND FUNCTION OF CELLS OF HUMAN EMBRYONIC LIVER IN MONOLAYER CULTURE

A system for culturing human fetal liver cells in monolayers is described and the effects of various conditions of growth on the morphology and function of the cultured cells are presented. The addition of 10% calf serum or 1% human serum to the growth medium accelerated the proliferation of the liver cells, with subsequent loss of characteristic morphology and specific functional activity. In the absence of serum, the cultured liver cells retained their morphology and their function for at least 4 wk, as evidenced by secretion of serum albumin and storage of glycogen and iron

Where Are the Baryons? II: Feedback Effects

Numerical simulations of the intergalactic medium have shown that at the present epoch a significant fraction (40-50%) of the baryonic component should be found in the (T~10^6K) Warm-Hot Intergalactic Medium (WHIM) - with several recent observational lines of evidence indicating the validity of the prediction. We here recompute the evolution of the WHIM with the following major improvements: (1) galactic superwind feedback processes from galaxy/star formation are explicitly included; (2) major metal species (O V to O IX) are computed explicitly in a non-equilibrium way; (3) mass and spatial dynamic ranges are larger by a factor of 8 and 2, respectively, than in our previous simulations. Here are the major findings: (1) galactic superwinds have dramatic effects, increasing the WHIM mass fraction by about 20%, primarily through heating up warm gas near galaxies with density 10^{1.5}-10^4 times the mean density. (2) the fraction of baryons in WHIM is increased modestly from the earlier work but is ~40-50%. (3) the gas density of the WHIM is broadly peaked at a density 10-20 times the mean density, ranging from underdense regions to regions that are overdense by 10^3-10^4. (4) the median metallicity of the WHIM is 0.18 Zsun for oxygen with 50% and 90% intervals being (0.040,0.38) and (0.0017,0.83).Comment: 44 pages, 17 figures, high res version at http://www.astro.princeton.edu/~cen/baryonII.ps.g

G1.9+0.3 – The New Kid on the Block

https://scholarworks.moreheadstate.edu/student_scholarship_posters/1149/thumbnail.jp

The Expected Mass Function for Low Mass Galaxies in a CDM Cosmology: Is There a Problem?

It is well known that the mass function for_halos_ in CDM cosmology is a relatively steep power law for low masses, possibly too steep to be consistent with observations. But how steep is the_galaxy_ mass function? We have analyzed the stellar and gas mass functions of the first massive luminous objects formed in a \Lambda CDM universe, as calculated in the numerical simulation described in Gnedin (2000ab). We found that while the dark matter mass function is steep, the stellar and gas mass functions are flatter for low mass objects. The stellar mass function is consistently flat at the low mass end. Moreover, while the gas mass function follows the dark matter mass function until reionization at z~7, between z=7 and z=4, the gas mass function also flattens considerably at the low mass end. At z=4, the gas and stellar mass functions are fit by a Schechter function with \alpha ~ -1.2 +/- 0.1, significantly shallower than the dark matter halo mass function and consistent with some recent observations. The baryonic mass functions are shallower because (a) the dark matter halo mass function is consistent with the Press-Schechter formulation at low masses n(M) M^-2 and (b) heating/cooling and ionization processes appear to cause baryons to collect in halos with the relationship M_b M_d^4 at low masses. Combining (a) and (b) gives n(M_b) M_b^-5/4, comparable to the simulation results. Thus, the well known observational fact that low mass galaxies are underabundant as compared to expectations from numerical dark matter simulations or Press-Schechter modeling of CDM universes emerges naturally from these results, implying that perhaps no ``new physics'' beyond the standard model is needed.Comment: Submitted to ApJ, 17 pages including 6 figure

The PAS Domain-Containing Protein HeuR Regulates Heme Uptake in Campylobacter jejuni

Campylobacter jejuni is a leading cause of bacterially derived gastroenteritis. A previous mutant screen demonstrated that the heme uptake system (Chu) is required for full colonization of the chicken gastrointestinal tract. Subsequent work identified a PAS domain-containing regulator, termed HeuR, as being required for chicken colonization. Here we confirm that both the heme uptake system and HeuR are required for full chicken gastrointestinal tract colonization, with the hour mutant being particularly affected during competition with wild-type C. jejuni. Transcriptomic analysis identified the chu genes—and those encoding other iron uptake systems—as regulatory targets of HeuR. Purified HeuR bound the chuZA promoter region in electrophoretic mobility shift assays. Consistent with a role for HeuR in chu expression, heuR mutants were unable to efficiently use heme as a source of iron under iron-limiting conditions, and mutants exhibited decreased levels of cell-associated iron by mass spectrometry. Finally, we demonstrate that an heuR mutant of C. jejuni is resistant to hydrogen peroxide and that this resistance correlates to elevated levels of catalase activity. These results indicate that HeuR directly and positively regulates iron acquisition from heme and negatively impacts catalase activity by an as yet unidentified mechanism in C. jejuni

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming undercooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains. As the incidence of antibiotic resistance, emergence of post-infectious diseases, and economic burden associated with Campylobacter increases, it is becoming urgent that novel treatments are developed to reduce Campylobacter numbers in commercial poultry and campylobacteriosis in humans. The purpose of this review is to provide the current status of present and proposed treatments to combat Campylobacter infection in humans and colonization in animal reservoirs. These treatments include anti- Campylobacter compounds, probiotics, bacteriophage, vaccines, and anti -Campylobacter bacteriocins, all of which may be successful at reducing the incidence of campylobacteriosis in humans and/or colonization loads in poultry. In addition to reviewing treatments, we will also address several proposed targets that may be used in future development of novel anti- Campylobacter treatments