Detection of X-ray emission from the host clusters of 3CR quasars

We report the detection of extended X-ray emission around several powerful 3CR quasars with redshifts out to 0.73. The ROSAT HRI images of the quasars have been corrected for spacecraft wobble and compared with an empirical point-spread function. All the quasars examined show excess emission at radii of 15 arcsec and more; the evidence being strong for the more distant objects and weak only for the two nearest ones, which are known from other wavelengths not to lie in strongly clustered environments. The spatial profiles of the extended component is consistent with thermal emission from the intracluster medium of moderately rich host clusters to the quasars. The total luminosities of the clusters are in the range 4x10^44 - 3x10^45 erg/s, assuming a temperature of 4keV. The inner regions of the intracluster medium are, in all cases, dense enough to be part of a cooling flow.Comment: 21 pages including 4 figures and 4 tables. To be published in MNRA

The Velocity Distribution of the Nearest Interstellar Gas

The bulk flow velocity for the cluster of interstellar cloudlets within about 30 pc of the Sun is determined from optical and ultraviolet absorption line data, after omitting from the sample stars with circumstellar disks or variable emission lines and the active variable HR 1099. Ninety-six velocity components towards the remaining 60 stars yield a streaming velocity through the local standard of rest of -17.0+/-4.6 km/s, with an upstream direction of l=2.3 deg, b=-5.2 deg (using Hipparcos values for the solar apex motion). The velocity dispersion of the interstellar matter (ISM) within 30 pc is consistent with that of nearby diffuse clouds, but present statistics are inadequate to distinguish between a Gaussian or exponential distribution about the bulk flow velocity. The upstream direction of the bulk flow vector suggests an origin associated with the Loop I supernova remnant. Groupings of component velocities by region are seen, indicating regional departures from the bulk flow velocity or possibly separate clouds. The absorption components from the cloudlet feeding ISM into the solar system form one of the regional features. The nominal gradient between the velocities of upstream and downstream gas may be an artifact of the Sun's location near the edge of the local cloud complex. The Sun may emerge from the surrounding gas-patch within several thousand years.Comment: Typographical errors corrected; Five tables, seven figures; Astrophysical Journal, in pres

Pulsar Science with the Green Bank 43m Telescope

The 43m telescope at the NRAO site in Green Bank, WV has recently been outfitted with a clone of the Green Bank Ultimate Pulsar Processing Instrument (GUPPI \cite{Ransom:2009}) backend, making it very useful for a number of pulsar related studies in frequency ranges 800-1600 MHz and 220-440 MHz. Some of the recent science being done with it include: monitoring of the Crab pulsar, a blind search for transient sources, pulsar searches of targets of opportunity, and an all-sky mapping project. For the Crab monitoring project, regular observations are searched for giant pulses (GPs), which are then correlated with $\gamma$-ray photons from the \emph{Fermi} spacecraft. Data from the all-sky mapping project are first run through a pipeline that does a blind transient search, looking for single pulses over a DM range of 0-500 pc~cm$^{-3}$. These projects are made possible by MIT Lincoln Labs.Comment: 2 pages, 1 figure, to appear in AIP Conference Proceedings of Pulsar Conference 2010 "Radio Pulsars: a key to unlock the secrets of the Universe", Sardinia, October 201

An audit of the quality of inpatient care for adults with learning disability in the UK

OBJECTIVES: To audit patient hospital records to evaluate the performance of acute general and mental health services in delivering inpatient care to people with learning disability and explore the influence of organisational factors on the quality of care they deliver. SETTING: Nine acute general hospital Trusts and six mental health services. PARTICIPANTS: Adults with learning disability who received inpatient hospital care between May 2013 and April 2014. PRIMARY AND SECONDARY OUTCOME MEASURES: Data on seven key indicators of high-quality care were collected from 176 patients. These covered physical health/monitoring, communication and meeting needs, capacity and decision-making, discharge planning and carer involvement. The impact of services having an electronic system for flagging patients with learning disability and employing a learning disability liaison nurse was assessed. RESULTS: Indicators of physical healthcare (body mass index, swallowing assessment, epilepsy risk assessment) were poorly recorded in acute general and mental health inpatient settings. Overall, only 34 (19.3%) patients received any assessment of swallowing and 12 of the 57 with epilepsy (21.1%) had an epilepsy risk assessment. For most quality indicators, there was a non-statistically significant trend for improved performance in services with a learning disability liaison nurse. The presence of an electronic flagging system showed less evidence of benefit. CONCLUSIONS: Inpatient care for people with learning disability needs to be improved. The work gives tentative support to the role of a learning disability liaison nurse in acute general and mental health services, but further work is needed to confirm these benefits and to trial other interventions that might improve the quality and safety of care for this high-need group

Active Galaxies and Cluster Gas

Two lines of evidence indicate that active galaxies, principally radio galaxies, have heated the diffuse hot gas in clusters. The first is the general need for additional heating to explain the steepness of the X-ray luminosity--temperature relation in clusters, the second is to solve the cooling flow problem in cluster cores. The inner core of many clusters is radiating energy as X-rays on a timescale much shorter than its likely age. Although the temperature in this region drops by a factor of about 3 from that of the surrounding gas, little evidence is found for gas much cooler than that. Some form of heating appears to be taking place, probably by energy transported outward from the central accreting black hole or radio source. How that energy heats the gas depends on poorly understood transport properties (conductivity and viscosity) of the intracluster medium. Viscous heating is discussed as a possibility. Such heating processes have consequences for the truncation of the luminosity function of massive galaxies.Comment: 14 pages, 16 fig, Feb 2004 talk for Phil Trans Roy So

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain

Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an intracellular family 1 cystatin) with KD2 and Delta L110 deletion mutants of chicken cystatin-KD2 hybrids. Substitution of the N-terminal contact region of stefin B by the corresponding KD2 sequence resulted in a calpain inhibitor of K-i = 188 nM. Deletion of L110, which forms a beta -bulge in family 1 and 2 cystatins but is lacking in KD2, improved inhibition of mu -calpain 4- to 8-fold. All engineered cystatins were temporary inhibitors of calpain due to slow substrate-like cleavage of a single peptide bond corresponding to Gly9-Ala10 in chicken cystatin. Biomolecular interaction analysis revealed that, unlike calpastatin, the cystatin-type inhibitors do not bind to the calmodulin-like domain of the small subunit of calpain, and their interaction with the mu -calpain heterodimer is completely prevented by a synthetic peptide comprising subdomain B of calpastatin domain 1. Based on these results we propose that (i) cystatin-type calpain inhibitors interact with the active site of the catalytic domain of calpain in a similar cystatin-like mode as with papain and (ii) the potential for calpain inhibition is due to specific subsites within the papain-binding regions of the general cystatin fold

Heavy Baryon Production and Decay

The branching ratio B(Lambda_c -> p K- pi+) normalizes the production and decay of charmed and bottom baryons. At present, this crucial branching ratio is extracted dominantly from B.bar -> baryons analyses. This note questions several of the underlying assumptions and predicts sizable B.bar -> D(*) N N'.bar X transitions, which were traditionally neglected. It predicts B(Lambda_c -> p K- pi+) to be significantly larger (0.07 +/- 0.02) than the world average. Some consequences are briefly mentioned. Several techniques to measure B(Lambda_c -> p K- pi+) are outlined with existing or soon available data samples. By equating two recent CLEO results, an appendix obtains B(D0 -> K- pi+)= 0.035 +/- 0.002, which is somewhat smaller than the current world average.Comment: 27 pages, 4 eps figures, revte

The Parkes Multibeam Pulsar Survey - II. Discovery and Timing of 120 Pulsars

The Parkes Multibeam Pulsar Survey is a sensitive survey of a strip of the Galactic plane with |b| \u3c 5° and 260° \u3c l \u3c 50° at 1374 MHz. Here we report the discovery of 120 new pulsars and subsequent timing observations, primarily using the 76-m Lovell radio telescope at Jodrell Bank. The main features of the sample of 370 published pulsars discovered during the multibeam survey are described. Furthermore, we highlight two pulsars: PSR J1734−3333, a young pulsar with the second highest surface magnetic field strength among the known radio pulsars, Bs= 5.4 × 1013 G, and PSR J1830−1135, the second slowest radio pulsar known, with a 6-s period

How animals collaborate : underlying proximate mechanisms

Funding: Templeton World Charity Foundation (Grant Number(s): TWCF0264).Collaboration or social interactions in which two or more individuals coordinate their behavior to produce outcomes from which both individuals benefit are common in nature. Individuals from many species hunt together, defend their territory, and form coalitions in intragroup competition. However, we still know very little about the proximate mechanisms underlying these behaviors. Recent theories of human cognitive evolution have emphasized the role collaboration may have played in the selection of socio‐cognitive skills. It has been argued that the capacity to form shared goals and joint intentions with others, is what allows humans to collaborate so flexibly and efficiently. Although there is no evidence that nonhuman animals are capable of shared intentionality, there is conceivably a wide range of proximate mechanisms that support forms of, potentially flexible, collaboration in other species. We review the experimental literature with the aim of evaluating what we know about how other species achieve collaboration; with a particular focus on chimpanzees. We structure the review with a new categorization of collaborative behavior that focuses on whether individuals intentionally coordinate actions with others. We conclude that for a wider comparative perspective we need more data from other species but the findings so far suggest that chimpanzees, and possibly other great apes, are capable of understanding the causal role of a partner in collaboration.Publisher PDFPeer reviewe

Timing the Parkes Multibeam Pulsars

Measurement of accurate positions, pulse periods and period derivatives is an essential follow-up to any pulsar survey. The procedures being used to obtain timing parameters for the pulsars discovered in the Parkes multibeam pulsar survey are described. Completed solutions have been obtained so far for about 80 pulsars. They show that the survey is preferentially finding pulsars with higher than average surface dipole magnetic fields. Eight pulsars have been shown to be members of binary systems and some of the more interesting results relating to these are presented.Comment: 6 pages, 2 embedded EPS figures, to be published in proceedings of "Pulsar Astronomy - 2000 and Beyond", ASP Conf. Se