State Prescription Drug Price Web Sites: How Useful to Consumers?

Compares ten sites and identifies key limitations due to data omissions, gaps between insured and uninsured consumers, and varied program implementation. Presents alternative policy options such as requiring price lists from pharmacies

Are Black Holes Elementary Particles?

Quantum black holes are the smallest and heaviest conceivable elementary particles. They have a microscopic size but a macroscopic mass. Several fundamental types have been constructed with some remarkable properties. Quantum black holes in the neighborhood of the Galaxy could resolve the paradox of ultra-high energy cosmic rays detected in Earth's atmosphere. They may also play a role as dark matter in cosmology.Comment: Lecture delivered in Conference on Particle Physics, Astrophysics and Quantum Field Theory: 75 Years since Solvay, 27 -29 November 2008, Nanyang Executive Centre, Singapore. 10 page

First-Fit is Linear on Posets Excluding Two Long Incomparable Chains

A poset is (r + s)-free if it does not contain two incomparable chains of size r and s, respectively. We prove that when r and s are at least 2, the First-Fit algorithm partitions every (r + s)-free poset P into at most 8(r-1)(s-1)w chains, where w is the width of P. This solves an open problem of Bosek, Krawczyk, and Szczypka (SIAM J. Discrete Math., 23(4):1992--1999, 2010).Comment: v3: fixed some typo

Spatial Control of Photoemitted Electron Beams using a Micro-Lens-Array Transverse-Shaping Technique

A common issue encountered in photoemission electron sources used in electron accelerators is the transverse inhomogeneity of the laser distribution resulting from the laser-amplification process and often use of frequency up conversion in nonlinear crystals. A inhomogeneous laser distribution on the photocathode produces charged beams with lower beam quality. In this paper, we explore the possible use of microlens arrays (fly-eye light condensers) to dramatically improve the transverse uniformity of the drive laser pulse on UV photocathodes. We also demonstrate the use of such microlens arrays to generate transversely-modulated electron beams and present a possible application to diagnose the properties of a magnetized beam.Comment: arXiv admin note: text overlap with arXiv:1609.0166

The best practice for preparation of samples from FTA®cards for diagnosis of blood borne infections using African trypanosomes as a model system

Background: Diagnosis of blood borne infectious diseases relies primarily on the detection of the causative agent in the blood sample. Molecular techniques offer sensitive and specific tools for this although considerable difficulties exist when using these approaches in the field environment. In large scale epidemiological studies, FTA®cards are becoming increasingly popular for the rapid collection and archiving of a large number of samples. However, there are some difficulties in the downstream processing of these cards which is essential for the accurate diagnosis of infection. Here we describe recommendations for the best practice approach for sample processing from FTA®cards for the molecular diagnosis of trypanosomiasis using PCR. Results: A comparison of five techniques was made. Detection from directly applied whole blood was less sensitive (35.6%) than whole blood which was subsequently eluted from the cards using Chelex®100 (56.4%). Better apparent sensitivity was achieved when blood was lysed prior to application on the FTA cards (73.3%) although this was not significant. This did not improve with subsequent elution using Chelex®100 (73.3%) and was not significantly different from direct DNA extraction from blood in the field (68.3%). Conclusions: Based on these results, the degree of effort required for each of these techniques and the difficulty of DNA extraction under field conditions, we recommend that blood is transferred onto FTA cards whole followed by elution in Chelex®100 as the best approach

Dynamic instability transitions in 1D driven diffusive flow with nonlocal hopping

One-dimensional directed driven stochastic flow with competing nonlocal and local hopping events has an instability threshold from a populated phase into an empty-road (ER) phase. We implement this in the context of the asymmetric exclusion process. The nonlocal skids promote strong clustering in the stationary populated phase. Such clusters drive the dynamic phase transition and determine its scaling properties. We numerically establish that the instability transition into the ER phase is second order in the regime where the entry point reservoir controls the current and first order in the regime where the bulk is in control. The first order transition originates from a turn-about of the cluster drift velocity. At the critical line, the current remains analytic, the road density vanishes linearly, and fluctuations scale as uncorrelated noise. A self-consistent cluster dynamics analysis explains why these scaling properties remain that simple.Comment: 11 pages, 14 figures (25 eps files); revised as the publised versio

Horizon Mass Theorem

A new theorem for black holes is found. It is called the horizon mass theorem. The horizon mass is the mass which cannot escape from the horizon of a black hole. For all black holes: neutral, charged or rotating, the horizon mass is always twice the irreducible mass observed at infinity. Previous theorems on black holes are: 1. the singularity theorem, 2. the area theorem, 3. the uniqueness theorem, 4. the positive energy theorem. The horizon mass theorem is possibly the last general theorem for classical black holes. It is crucial for understanding Hawking radiation and for investigating processes occurring near the horizon.Comment: A new theorem for black holes is establishe

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

Galectin-1 (Gal-1), a glycan-binding protein with broad antiinflammatory activities, functions as a proresolving mediator in autoimmune and chronic inflammatory disorders. However, its role in allergic airway inflammation has not yet been elucidated. We evaluated the effects of Gal-1 on eosinophil function and its role in a mouse model of allergic asthma. Allergen exposure resulted in airway recruitment of Gal-1-expressing inflammatory cells, including eosinophils, as well as increased Gal-1 in extracellular spaces in the lungs. In vitro, extracellular Gal-1 exerted divergent effects on eosinophils that were N-glycan- And dose-dependent. At concentrations ≤0.25 μM, Gal-1 increased eosinophil adhesion to vascular cell adhesion molecule-1, caused redistribution of integrin CD49d to the periphery and cell clustering, but inhibited ERK(1/2) activation and eotaxin-1-induced migration. Exposure to concentrations ≥1 μM resulted in ERK(1/2)- dependent apoptosis and disruption of the F- Actin cytoskeleton. At lower concentrations, Gal-1 did not alter expression of adhesion molecules (CD49d, CD18, CD11a, CD11b, L-selectin) or of the chemokine receptor CCR3, but decreased CD49d and CCR3 was observed in eosinophils treated with higher concentrations of this lectin. In vivo, allergen-challenged Gal-1-deficient mice exhibited increased recruitment of eosinophils and CD3+ T lymphocytes in the airways as well as elevated peripheral blood and bone marrow eosinophils relative to corresponding WT mice. Further, these mice had an increased propensity to develop airway hyperresponsiveness and displayed significantly elevated levels of TNF-α in lung tissue. This study suggests that Gal-1 can limit eosinophil recruitment to allergic airways and suppresses airway inflammation by inhibiting cell migration and promoting eosinophil apoptosis.Fil: Ge, Xiao Na. University of Minnesota; Estados UnidosFil: Ha, Sung Gil. University of Minnesota; Estados UnidosFil: Greenberg, Yana G.. University of Minnesota; Estados UnidosFil: Rao, Amrita. University of Minnesota; Estados UnidosFil: Bastan, Idil. University of Minnesota; Estados UnidosFil: Blidner, Ada Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rao, Savita P.. University of Minnesota; Estados UnidosFil: Rabinovich, Gabriel Adrián. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sriramarao, P.. University of Minnesota; Estados Unido