Grosulfeimin and new related guaianolides from cynara scolymus L.

Three new guaianolides 11-H-13-rnethylsulfonylgrosheirnin 5 (Grosulfeirnin), 8-deoxy-11, 13-dihydroxygrosheimin 7 and 8-deoxy-11-hydroxy-13-chlorogrosheimin 8 have been isolated from the leaves of Cynara scolymus L. Besides, 8-epigrosheirnin 9 has been isolated for the ftrst time frorn this source. The structures were deterrnined by spectroscopical rnethods and by chernical correlations

English

Three new guaianolides 11-H-13-rnethylsulfonylgrosheirnin 5 (Grosulfeirnin), 8-deoxy-11, 13-dihydroxygrosheimin 7 and 8-deoxy-11-hydroxy-13-chlorogrosheimin 8 have been isolated from the leaves of Cynara scolymus L. Besides, 8-epigrosheirnin 9 has been isolated for the ftrst time frorn this source. The structures were deterrnined by spectroscopical rnethods and by chernical correlations

Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines .10. Synthesis and inhibition of benzodiazepine receptor binding of new 1,4-thiazine and 1,5-thiazepine polycondensed heterocycles with steroidal structure

Some naphthol [1,2,-b]-s-triazolo[4,3-d]-1,4-thiazine and 1,5-thiazepine and s-triazolo[4',3'-4,5]-1, ,4-thiazino[3,2-c]quinoline derivatives have been synthesized and tested for their ability to displace [H-3]RO 15-1788 binding from bovine brain membranes. Several compounds showed moderate binding affinity for the benzodiazepine receptor