Penerapan Model Pembelajaran Kooperatif Tipe Studen Theams Achievement Divisions (Stad) untuk Meningkatkan Hasil Belajar IPS Siswa Kelas V SD Negeri 025 Sungai Tunggak Kecamatan Kubu

The problem in this study is the low IPS student learning outcomes. Thepurpose of this research is to improve learning outcomes IPS Elementary Schoolfifth grade students 25 Tunggak River, the Application Model Type CooperativeStudent Teams Achievement Division (STAD). The hypothesis of this study is thatif applied STAD cooperative learning model, it can improve learning outcomesIPS Elementary School fifth grade students Tunggak River 025. The resultsshowed the activity of teachers in the first cycle showed 60% first meeting, asecond meeting of the first cycle of 70%, the second cycle of the third meeting86.66%, the fourth meeting of Cycle II 86.66%. Activity of teachers in this studyincreased. Student activity first cycle of 60% the first meeting, a second meetingof the first cycle 66.66%, the second cycle of the third meeting of 76.66%, thefourth meeting of Cycle II 83.33%. Activity of students in this study alsoincreased. The results of the initial data menunnjukkan social studies whocompleted only 12 percent of students with 40% who did not complete 18 percentof people with 60%. Students who earn a score above the basic standard minimumcompleteness criteria (KKM) in the first UH students who complete 21 or 70% thepercentage of incomplete 9 people with the percentage of 30%. In the second UHstudents who completed 28 or 93.33% percentage of incomplete 2 people or apercentage of 6.66%. IPS learning outcomes in this study is increased, then theapplication of learning models of type Cooperative Students Teams AchievementDivision (STAD) Social learning results receive

Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to improve the therapeutic potential for AD, we utilized a promising new approach for delivery of proteins across the BBB. We generated a lentivirus vector expressing the amyloid β-degrading enzyme, neprilysin, fused to the ApoB transport domain and delivered this by intra-peritoneal injection to amyloid protein precursor (APP) transgenic model of AD. Treated mice had reduced levels of Aβ, reduced plaques and increased synaptic density in the CNS. Furthermore, mice treated with the neprilysin targeting the CNS had a reversal of memory deficits. Thus, the addition of the ApoB transport domain to the secreted neprilysin generated a non-invasive therapeutic approach that may be a potential treatment in patients with AD

Integrating anatomical priors in ECT reconstruction via joint mixtures and mutual information

We present a joint mixture model for integrating anatomical information in ECT reconstruction. The mixture model acts as a Bayesian prior with the added benefit of the anatomical segmentation pixel-region labels guiding the reconstruction process. An additional hyper-prior on the mixture occupation probability is introduced. This has the novel interpretation of maximizing the mutual information between the anatomical image and the evolving ECT reconstruction. Results are presented on a phantom with the bias/variance tradeoff being the indicator of performance

Cigar smoking prevalence and morbidity among US adults, 2000–2015

Cigar smoking causes many of the same health conditions as cigarettes, but less information is available on prevalence of use trends and the disease burden of cigar smoking in the US. To examine these issues, we analyzed cigar use and health condition data from the National Health Interview Survey from 2000, 2005, 2010, and 2015, estimating prevalence of use by year and over time. We also estimated the number of, and adjusted disease prevalence ratios for, US adults aged ≥35 years with self-reported history of heart disease, stroke, or cancer attributable to cigar smoking. We found that prevalence of current cigar smoking has remained generally stable at around 2.3% among US adults aged ≥18 years between 2000 and 2015 but has increased among female and non-Hispanic black adults. Former exclusive cigar smokers were more likely to report having had heart conditions (aPR = 1.33, 95% CI = 1.03–1.72), stroke (aPR = 2.42, 95% CI = 1.57–3.75), and cancer (aPR = 1.44, 95% CI = 1.09–1.88) than never cigar smokers. It is estimated that nearly 200,000 cardiovascular conditions and cancer cases among US adults are attributable to former exclusive cigar smoking. This analysis shows that prevalence of current cigar smoking has remained stable among US adults but has increased among certain demographic groups. Former exclusive cigar use is associated with increased prevalence of heart disease, stroke, and cancer, which may result in part from smoking cessation following disease onset. Keywords: Cigar, Tobacco, Cardiovascular, Stroke, Cance