Toward a precision, complexity-informed cultural policy design: Structural bottlenecks to culture-led development in Skaraborg, Sweden

We analyze the spatial-temporal dynamics of cultural vibrancy in the Swedish sub-region of Skaraborg. Our database consists of 4170 geo-localized cultural activities and facilities, mapped between October 2013 and March 2014. We make use of the TWC methodology for the dynamic simulation of the evolution of geo-localized activity starting from an observed distribution of events, and of the AutoCM ANN architecture to understand how cultural variables are related to the rest of the Skaraborg socio-economy. We find that cultural vibrancy in Skaraborg is likely characterized by a 'flaring' pattern of initial, widespread activity followed by a re-concentration into the main local urban hubs. The deep reason behind this unsuccessful developmental trajectory is the lack of centrality of cultural production in the local socio-economy, and of integration across cultural production sectors. This is in turn due also to structural bottlenecks of a non-cultural nature such as insufficient access of women to higher education. We make a case for the necessity to develop a new precision cultural policy design approach founded upon the science of complexity for both policy design and assessment, and we provide and illustrate a first technical toolkit to this purpose.(c) 2022 Elsevier B.V. All rights reserved

A nonlinear, data-driven, ANNs-based approach to culture-led development policies in rural areas: The case of Gjakove and Pee districts, Western Kosovo

We develop a computational approach to the analysis of cultural vibrancy and to the role of the cultural and cre-ative sectors in the socio-economic organization of two districts of Western Kosovo, Gjakove and Pee. Our anal-ysis is built on a geolocalized mapping of the cultural activities and facilities, and on the main socio-economic variables for the two districts, and makes use of innovative data analysis techniques: Theory of Impossible Words (TIW), the Topological Weighted Centroid (TWC), and the AutoCM ANN. We find that the dynamics of cul-tural vibrancy of the territory is mainly driven by the competing attraction pulls of the nearby countries of Serbia and Albania, that also form the region's main and often conflicting ethnicities, and that such dynamics are likely to further polarize in the future. We also find that the cultural system plays a marginal role in the territory's socio-economic organization. This situation makes a case for a more active role of cultural policy in shaping future local developmental models in rural areas and in acting as an agent of social cohesion.(c) 2022 Elsevier Ltd. All rights reserved

Reconstructing the Emergent Organization of Information Flows in International Stock Markets: A Computational Complex Systems Approach

In this paper we study the interdependences between the dynamics of the stock market indexes of 30 different stock markets across 29 different countries to analyze the nonlinear dynamics of their information flows. We find that the system exhibits complex dynamic properties that go beyond what has been generally found in the previous literature, suggesting that the structure of information flows is regulated by subtle homeostatic forces that cause the roles of the single markets in the whole network to evolve in unexpected ways. We present a toolkit of ANN-based methods that can be systematically deployed to analyze different aspects of such dynamics

Business model and ESG pillars: The impacts on banking default risk

The recent banks' failures have highlighted the importance of improving banking sector supervision, emphasizing the need to adopt a holistic approach to risk assessment based on an evaluation of a bank's business model (BBM) that combines financial (e.g., bank's balance data) and non-financial information (e.g., bank's ESG performance). In this study, we explore the joint effect of BBM and their environmental (ENV), social (SOC), and governance (GOV) pillars performance on banks' riskiness profile. The study uses a sample of 639 EU banks from 2013 to 2022 and applied a random effects model. Our findings suggest wholesale and retail banks could mitigate default risk, enhancing their ENV pillar performance. Differently, investment banks are encouraged to improve their governance best practices and structure to take advantage in terms of riskiness reduction. These results remain consistent after a series of robustness tests, including the 2SLS model and the Arellano coefficient estimation. Our paper offers practical implications for banking supervisory authorities and practitioners, encouraging to adopt a diversified ESG investment strategy according to bank-specific business models

Neuropsychological performances, quality of life, and psychological issues in pediatric onset multiple sclerosis: a narrative review

Multiple sclerosis (MS) is primarily a disease diagnosed in young and middle-aged adults. Although MS is a rare condition in pediatric age, an increasing rate of patients is diagnosed under the age of 18. The disabling nature of the disease cannot be reduced only to physical symptoms. Several additional symptoms such as cognitive impairment, fatigue, and psychological symptoms are common features of pediatric MS. The reviewed literature suggests that, despite the lower physical disability, children and adolescents diagnosed with MS are vulnerable to cognitive impairment even in the early stage of the disease. The neuropsychological profile of pediatric MS may resemble that of adult MS, including an impairment in attention/information processing speed, learning, verbal, and visuospatial memory. However, cognitive difficulties in children and adolescents are more likely to involve also general intelligence and linguistic abilities, presumably due to patients’ younger age and cognitive growth stage. Cognitive difficulties, beyond physical disability and relapses, may have a considerable impact on learning and school achievement. Depression and fatigue are other highly prevalent disturbances in pediatric MS and may contribute to patients’ low functional outcomes. Overall, these manifestations may cause considerable functional impairment on daily activities and quality of life that may require individualized rehabilitative treatment and extensive psychosocial care. Additional neuropsychological research evaluating larger samples, using more homogenous methods, and exploring the role of MS treatment on cognitive and psychological development is required

Safety of SARS-CoV2 vaccination and COVID-19 short-term outcome in pediatric acquired demyelinating disorders of central nervous system: A single center experience

IntroductionConcern of a correlation between disease relapse in patients with acquired demyelinating disorders of central nervous system (CNS) and SARS-CoV2 vaccines has been raised. In this single center study, we retrospectively evaluated safety of SARS-CoV2 vaccination and COVID-19 short-term outcome in pediatric acquired demyelinating disorders of CNS. Materials and methodsPatients with multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) and neuromyelitis optica spectrum disorder (NMOSD) with disease onset before 18 years of age were included. Demographic and clinical data, and information regarding previous SARS-CoV-2 infection and vaccination were collected. ResultsWe included nine patients with MOGAD. Six patients received SARS-CoV2 vaccination and complained pain at injection site while only one had fever and fatigue. Median follow-up was 28 weeks (range 20-48). Seven patients had COVID-19 occurring with mild flu-like symptoms and median follow-up was 28 weeks (range 24-34). Nobody had disease relapse. Five patients with NMOSD were included. All patients received SARS-CoV2 vaccination (BNT162b2-Pfizer-BioNTech). The median follow-up was 20 weeks (range 14-24) and only two patients complained pain at injection site, fever and fatigue. Three patients had also COVID-19 with mild flu-like symptoms, despite two of them being under immunosuppressive treatment. Lastly, forty-three patients with MS were included. 35 out of 43 received SARS-CoV2 vaccination with a median follow-up of 24 weeks (range 8-36). Fourteen patients had no side effects, while 21 complained mild side effects (mainly pain at injection site) and one experienced a disease relapse with complete recovery after steroid therapy. At vaccination, all but one were under treatment. Sixteen patients had COVID-19 occurring with mild symptoms. DiscussionCOVID-19 outcome was good although many patients were under immunosuppressive treatment. Vaccine-related side effects were frequent but were mild and self-limited. Only one MS patient had a post-vaccination relapse with complete recovery after steroid therapy. In conclusion, our data support the safety of SARS-CoV-2 vaccines in pediatric MS, MOGAD and NMOSD

Lower Urinary Tract Dysfunction in Pediatric Patients with Multiple Sclerosis: Diagnostic and Management Concerns

background: multiple sclerosis (MS) is increasing in the pediatric population and, as in adults, symptoms vary among patients. in children the first manifestations can sometimes overlap with acute neurological symptoms. urological symptoms have not been much studied in childhood. we shared our experience with MS urological manifestation in children. methods: this article is a retrospective evaluation of all children with MS, according to the Krupp criteria, who also present with urological symptoms. we collected demographic and clinical history, the MR localization of demyelinating lesions, urological symptoms, and exams. results: we report on six MS pediatric cases with urological manifestation. urinary symptoms, characterized by urinary incontinence in five patients and urinary retention in one patient, appeared in a different time frame from MS diagnosis. urodynamic exams showed both overactive and underactive bladder patterns. treatment was defined according to lower urinary tract dysfunction, using clean intermittent catheterization, oxybutynin, and intradetrusor onabotulinum toxin-a injection. a low acceptance rate of invasive evaluation and urological management was observed. conclusions: the MS diagnosis was traumatic for all our patients. we believe it is important to address urological care in young people from the time of diagnosis for prompt management; it could be useful to include a pediatric urologist in multidisciplinary teams

Early Immunotherapy and Longer Corticosteroid Treatment Are Associated With Lower Risk of Relapsing Disease Course in Pediatric MOGAD

Background and Objectives We sought to identify early factors associated with relapse and outcome in paediatric-onset myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD). Methods In a multicenter retrospective cohort of pediatric MOGAD (≤18 years), onset features and treatment were compared in patients with monophasic vs relapsing disease (including cases with follow-up ≥12 months after onset or relapse at any time) and in patients with final Expanded Disability Status Scale (EDSS) 0 vs ≥1 at last follow-up (including cases with followup >3 months after last event or EDSS0 at any time). Multivariable logistic regression models were used to evaluate factors associated with relapsing disease course and EDSS ≥ 1 at final follow-up. Results Seventy-five children were included (median onset age 7 years; median 30 months of follow-up). Presentation with acute disseminated encephalomyelitis was more frequent in children aged 8 years or younger (66.7%, 28/42) than in older patients (30.3%, 10/33) (p = 0.002), whereas presentation with optic neuritis was more common in children older than 8 years (57.6%, 19/33) than in younger patients (21.4%, 9/42) (p = 0.001). 40.0% (26/65) of patients relapsed. Time to first relapse was longer in children aged 8 years or younger than in older patients (median 18 vs 4 months) (p = 0.013). Factors at first event independently associated with lower risk of relapsing disease course were immunotherapy <7 days from onset (6.7-fold reduced odds of relapsing course, OR 0.15, 95% CI 0.03–0.61, p = 0.009), corticosteroid treatment for ≥5 weeks (6.7-fold reduced odds of relapse, OR 0.15, 95% CI 0.03–0.80, p = 0.026), and abnormal optic nerves on onset MRI (12.5-fold reduced odds of relapse, OR 0.08, 95% CI 0.01–0.50, p = 0.007). 21.1% (15/71) had EDSS ≥ 1 at final follow-up. Patients with a relapsing course had a higher proportion of final EDSS ≥ 1 (37.5%, 9/24) than children with monophasic disease (12.8%, 5/39) (p = 0.022, univariate analysis). Each 1-point increment in worst EDSS at onset was independently associated with 6.7-fold increased odds of final EDSS ≥ 1 (OR 6.65, 95% CI 1.33–33.26, p = 0.021). Discussion At first attack of pediatric MOGAD, early immunotherapy, longer duration of corticosteroid treatment, and abnormal optic nerves on MRI seem associated with lower risk of relapse, whereas higher disease severity is associated with greater risk of final disability (EDSS ≥ 1)