2 research outputs found
ΠΠ΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΊΠ»ΡΡΠ½ΡΡ Π²Π°ΠΊΡΠΈΠ½ Ρ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ²
Aim: to investigate the safety of acellular pertussis vaccines for adolescents.Materials and methods. The clinical tolerability of revaccination against pertussis (cell-free component), diphtheria and tetanus was analyzed in 107 children aged 13,5β14 years. Group 1 consisted of children revaccinated with DTacP-IPV combined vaccine (Tetraxim), group 2 β vaccinated with Td and group 3 β children who received Tdap vaccine (Adacel).Results. Statistically significant differences in the frequency of local reactions between the group that received Tdap and the other two (DTacP-IPV and Td) were detected (p = 0.001and p = 0.04, respectively). Analysis of the structure of local reactions revealed a difference only in the occurrence of the hyperemia at the site of injection, with the most frequent registration in the groups of children vaccinated with DTacPIPV (29,4%) and Td (14,7%), whereas in patients vaccinated with Tdap β only in 5,9% (Ο2 = 6,8 p = 0,03). Systemic reactions occurred with the same frequency in all studied groups and did not require medical correction, as well as local reactions. Thus, revaccination against pertussis, diphtheria and tetanus of adolescents using Tdap, containing the acellular pertussis component, does not exceed the frequency of systemic reactions and the number of local reactions is significantly lower in comparison with the vaccine with a reduced content of diphtheria and tetanus toxoids (Td) that is used in practice for a long time.Π¦Π΅Π»Ρ: ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°ΡΠ΅Π»Π»ΡΠ»ΡΡΠ½ΡΡ
ΠΊΠΎΠΊΠ»ΡΡΠ½ΡΡ
Π²Π°ΠΊΡΠΈΠ½ Ρ ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ².ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΠΈ ΡΠ΅Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΠΈ ΠΏΡΠΎΡΠΈΠ² ΠΊΠΎΠΊΠ»ΡΡΠ° (Π±Π΅ΡΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ), Π΄ΠΈΡΡΠ΅ΡΠΈΠΈ ΠΈ ΡΡΠΎΠ»Π±Π½ΡΠΊΠ° Ρ 107 Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 13,5β14 Π»Π΅Ρ. 1 Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ Π΄Π΅ΡΠΈ, ΡΠ΅Π²Π°ΠΊΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΠΠ±ΠΠΠ‘-ΠΠΠ (Π’Π΅ΡΡΠ°ΠΊΡΠΈΠΌ), 2 Π³ΡΡΠΏΠΏΡ β ΠΏΡΠΈΠ²ΠΈΡΡΠ΅ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΠΠΠ‘-Π ΠΈ 3 Π³ΡΡΠΏΠΏΡ β Π΄Π΅ΡΠΈ, ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠΈΠ΅ Π²Π°ΠΊΡΠΈΠ½Ρ ΠΠ±ΠΠΠ‘-Π (ΠΠ΄Π°ΡΠ΅Π»Ρ).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ²Π»Π΅Π½Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ ΠΏΠΎ ΡΠ°ΡΡΠΎΡΠ΅ Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΠΈ ΠΌΠ΅ΡΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΡΠΏΠΏΠΎΠΉ, ΠΏΠΎΠ»ΡΡΠΈΠ²ΡΠ΅ΠΉ ΠΠ±ΠΠΠ‘-Π, ΠΈ Π΄Π²ΡΠΌΡ Π΄ΡΡΠ³ΠΈΠΌΠΈ (ΠΠ±ΠΠΠ‘-ΠΠΠ ΠΈ ΠΠΠ‘-Π) (p=0,001 ΠΈ p=0,04 ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ). ΠΠ½Π°Π»ΠΈΠ· ΡΡΡΡΠΊΡΡΡΡ ΠΌΠ΅ΡΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ Π²ΡΡΠ²ΠΈΠ» ΡΠ°Π·Π»ΠΈΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΠΎ ΡΠ°ΡΡΠΎΡΠ΅ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π³ΠΈΠΏΠ΅ΡΠ΅ΠΌΠΈΠΈ Π½Π° ΠΌΠ΅ΡΡΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΠ°Ρ Π±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ ΠΎΡΠΌΠ΅ΡΠ°Π»Π°ΡΡ Π² Π³ΡΡΠΏΠΏΠ°Ρ
Π΄Π΅ΡΠ΅ΠΉ, ΠΏΡΠΈΠ²ΠΈΡΡΡ
ΠΠ±ΠΠΠ‘-ΠΠΠ (29,4%) ΠΈ ΠΠΠ‘-Π (14,7%), ΡΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΡΠ΅Π²Π°ΠΊΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΠ±ΠΠΠ‘-Π, ΡΠ΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»Π°ΡΡ ΡΠΎΠ»ΡΠΊΠΎ Π² 5,9% (Ο2 =6,8 p=0,03). Π‘ΠΈΡΡΠ΅ΠΌΠ½ΡΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ Π²ΡΡΡΠ΅ΡΠ°Π»ΠΈΡΡ Ρ ΠΎΠ΄ΠΈΠ½Π°ΠΊΠΎΠ²ΠΎΠΉ ΡΠ°ΡΡΠΎΡΠΎΠΉ Π²ΠΎ Π²ΡΠ΅Ρ
ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΈ Π½Π΅ ΡΡΠ΅Π±ΠΎΠ²Π°Π»ΠΈ ΠΌΠ΅Π΄ΠΈΠΊΠ°ΠΌΠ΅Π½ΡΠΎΠ·Π½ΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ, ΡΠ°ΠΊ ΠΆΠ΅, ΠΊΠ°ΠΊ ΠΈ ΠΌΠ΅ΡΡΠ½ΡΠ΅ ΡΠ΅Π°ΠΊΡΠΈΠΈ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ΅Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΡ ΠΏΡΠΎΡΠΈΠ² ΠΊΠΎΠΊΠ»ΡΡΠ°, Π΄ΠΈΡΡΠ΅ΡΠΈΠΈ ΠΈ ΡΡΠΎΠ»Π±Π½ΡΠΊΠ° ΠΏΠΎΠ΄ΡΠΎΡΡΠΊΠΎΠ² Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΠ±ΠΠΠ‘-Π, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π³ΠΎ Π±Π΅ΡΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΊΠΎΠΊΠ»ΡΡΠ½ΡΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ, Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΠ°ΡΡΠΎΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ, Π° ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΌΠ΅ΡΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π½ΠΈΠΆΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΈΡ
Β Π²ΡΡΡΠ΅ΡΠ°Π΅ΠΌΠΎΡΡΡΡ ΠΏΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ Π΄Π°Π²Π½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΠΎΠΉ Π½Π° ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ Π²Π°ΠΊΡΠΈΠ½Ρ Ρ ΡΠΌΠ΅Π½ΡΡΠ΅Π½Π½ΡΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π΄ΠΈΡΡΠ΅ΡΠΈΠΉΠ½ΠΎΠ³ΠΎ ΠΈ ΡΡΠΎΠ»Π±Π½ΡΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°ΡΠΎΠΊΡΠΈΠ½ΠΎΠ² ΠΠΠ‘-Π.
Safety of pertussis vaccines for adolescents
Aim: to investigate the safety of acellular pertussis vaccines for adolescents.Materials and methods. The clinical tolerability of revaccination against pertussis (cell-free component), diphtheria and tetanus was analyzed in 107 children aged 13,5β14 years. Group 1 consisted of children revaccinated with DTacP-IPV combined vaccine (Tetraxim), group 2 β vaccinated with Td and group 3 β children who received Tdap vaccine (Adacel).Results. Statistically significant differences in the frequency of local reactions between the group that received Tdap and the other two (DTacP-IPV and Td) were detected (p = 0.001and p = 0.04, respectively). Analysis of the structure of local reactions revealed a difference only in the occurrence of the hyperemia at the site of injection, with the most frequent registration in the groups of children vaccinated with DTacPIPV (29,4%) and Td (14,7%), whereas in patients vaccinated with Tdap β only in 5,9% (Ο2 = 6,8 p = 0,03). Systemic reactions occurred with the same frequency in all studied groups and did not require medical correction, as well as local reactions. Thus, revaccination against pertussis, diphtheria and tetanus of adolescents using Tdap, containing the acellular pertussis component, does not exceed the frequency of systemic reactions and the number of local reactions is significantly lower in comparison with the vaccine with a reduced content of diphtheria and tetanus toxoids (Td) that is used in practice for a long time