1,379 research outputs found
From attosecond to zeptosecond coherent control of free-electron wave functions using semi-infinite light fields
Light-electron interaction in empty space is the seminal ingredient for
free-electron lasers and also for controlling electron beams to dynamically
investigate materials and molecules. Pushing the coherent control of free
electrons by light to unexplored timescales, below the attosecond, would enable
unprecedented applications in light-assisted electron quantum circuits and
diagnostics at extremely small timescales, such as those governing
intramolecular electronic motion and nuclear phenomena. We experimentally
demonstrate attosecond coherent manipulation of the electron wave function in a
transmission electron microscope, and show that it can be pushed down to the
zeptosecond regime with existing technology. We make a relativistic pulsed
electron beam interact in free space with an appropriately synthesized
semi-infinite light field generated by two femtosecond laser pulses reflected
at the surface of a mirror and delayed by fractions of the optical cycle. The
amplitude and phase of the resulting coherent oscillations of the electron
states in energymomentum space are mapped via momentum-resolved ultrafast
electron energy-loss spectroscopy. The experimental results are in full
agreement with our theoretical framework for light-electron interaction, which
predicts access to the zeptosecond timescale by combining semi-infinite X-ray
fields with free electrons.Comment: 22 pages, 6 figure
Energy Spectra, Altitude Profiles and Charge Ratios of Atmospheric Muons
We present a new measurement of air shower muons made during atmospheric
ascent of the High Energy Antimatter Telescope balloon experiment. The muon
charge ratio mu+ / mu- is presented as a function of atmospheric depth in the
momentum interval 0.3-0.9 GeV/c. The differential mu- momentum spectra are
presented between 0.3 and about 50 GeV/c at atmospheric depths between 13 and
960 g/cm^2. We compare our measurements with other recent data and with Monte
Carlo calculations of the same type as those used in predicting atmospheric
neutrino fluxes. We find that our measured mu- fluxes are smaller than the
predictions by as much as 70% at shallow atmospheric depths, by about 20% at
the depth of shower maximum, and are in good agreement with the predictions at
greater depths. We explore the consequences of this on the question of
atmospheric neutrino production.Comment: 11 pages, 8 figures, to appear in Phys. Rev. D (2000
RICE Limits on the Diffuse Ultra-High Energy Neutrino Flux
We present new limits on ultra-high energy neutrino fluxes above 100 PeV
based on data collected by the Radio Ice Cherenkov Experiment (RICE) at the
South Pole from 1999-2005. We discuss estimation of backgrounds, calibration
and data analysis algorithms (both on-line and off-line), procedures used for
the dedicated neutrino search, and refinements in our Monte Carlo (MC)
simulation, including recent in situ measurements of the complex ice dielectric
constant. An enlarged data set and a more detailed study of hadronic showers
results in a sensitivity improvement of more than one order of magnitude
compared to our previously published results. Examination of the full RICE data
set yields zero acceptable neutrino candidates, resulting in 95%
confidence-level model dependent limits on the flux
(E_\nu)^2(d\phi/dE_\nu)<10^{-6} GeV/(cm^2s~sr}) in the energy range 10^{17}<
E_\nu< 10^{20} eV. The new RICE results rule out the most intense flux model
projections at 95% confidence level.Comment: Submitted to Astropart. Phy
The Energy Spectra and Relative Abundances of Electrons and Positrons in the Galactic Cosmic Radiation
Observations of cosmic-ray electrons and positrons have been made with a new
balloon-borne detector, HEAT (the "High-Energy Antimatter Telescope"), first
flown in 1994 May from Fort Sumner, NM. We describe the instrumental approach
and the data analysis procedures, and we present results from this flight. The
measurement has provided a new determination of the individual energy spectra
of electrons and positrons from 5 GeV to about 50 GeV, and of the combined
"all-electron" intensity (e+ + e-) up to about 100 GeV. The single power-law
spectral indices for electrons and positrons are alpha = 3.09 +/- 0.08 and 3.3
+/- 0.2, respectively. We find that a contribution from primary sources to the
positron intensity in this energy region, if it exists, must be quite small.Comment: latex2e file, 30 pages, 15 figures, aas2pp4.sty and epsf.tex needed.
To appear in May 10, 1998 issue of Ap.
Observations of the Askaryan Effect in Ice
We report on the first observations of the Askaryan effect in ice: coherent
impulsive radio Cherenkov radiation from the charge asymmetry in an
electromagnetic (EM) shower. Such radiation has been observed in silica sand
and rock salt, but this is the first direct observation from an EM shower in
ice. These measurements are important since the majority of experiments to date
that rely on the effect for ultra-high energy neutrino detection are being
performed using ice as the target medium. As part of the complete validation
process for the Antarctic Impulsive Transient Antenna (ANITA) experiment, we
performed an experiment at the Stanford Linear Accelerator Center (SLAC) in
June 2006 using a 7.5 metric ton ice target, yielding results fully consistent
with theoretical expectations.Comment: 4 pages, 5 figures, minor correction
Aromatic L-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies
Aromatic L-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological disorder of monoamine synthesis which results in dopamine and serotonin deficiency. The majority of affected individuals have variable, though often severe cognitive and motor delay, with a complex movement disorder and high risk of premature mortality. For most, standard pharmacological treatment provides only limited clinical benefit. Promising gene therapy approaches are emerging, though may not be either suitable or easily accessible for all patients. In order to better characterize the underlying disease pathophysiology and guide precision therapies, we generated a patient-derived midbrain dopaminergic (mDA) neuronal model of AADC deficiency from induced pluripotent stem cells (iPSCs). The neuronal model recapitulates key disease features, including absent AADC enzyme activity and dysregulated dopamine metabolism. We observed developmental defects affecting synaptic maturation and neuronal electrical properties, which were improved by lentiviral gene therapy. Bioinformatic and biochemical analyses on recombinant AADC predicted that the activity of one variant could be improved by L-3,4-dihydroxyphenylalanine (L-DOPA) administration; this hypothesis was corroborated in the patient-derived neuronal model, where L-DOPA treatment leads to amelioration of dopamine metabolites. Our study has shown that patient-derived disease modelling provides further insight into the neurodevelopmental sequelae of AADC deficiency, as well as a robust platform to investigate and develop personalised therapeutic approaches
Aromatic l-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies
Aromatic l-amino acid decarboxylase (AADC) deficiency is a complex inherited neurological disorder of monoamine synthesis which results in dopamine and serotonin deficiency. The majority of affected individuals have variable, though often severe cognitive and motor delay, with a complex movement disorder and high risk of premature mortality. For most, standard pharmacological treatment provides only limited clinical benefit. Promising gene therapy approaches are emerging, though may not be either suitable or easily accessible for all patients. To characterize the underlying disease pathophysiology and guide precision therapies, we generated a patient-derived midbrain dopaminergic neuronal model of AADC deficiency from induced pluripotent stem cells. The neuronal model recapitulates key disease features, including absent AADC enzyme activity and dysregulated dopamine metabolism. We observed developmental defects affecting synaptic maturation and neuronal electrical properties, which were improved by lentiviral gene therapy. Bioinformatic and biochemical analyses on recombinant AADC predicted that the activity of one variant could be improved by l-3,4-dihydroxyphenylalanine (l-DOPA) administration; this hypothesis was corroborated in the patient-derived neuronal model, where l-DOPA treatment leads to amelioration of dopamine metabolites. Our study has shown that patient-derived disease modelling provides further insight into the neurodevelopmental sequelae of AADC deficiency, as well as a robust platform to investigate and develop personalized therapeutic approaches
Minimal Mass Matrices for Dirac Neutrinos
We consider the possibility of neutrinos being Dirac particles and study
minimal mass matrices with as much zero entries as possible. We find that up to
5 zero entries are allowed. Those matrices predict one vanishing mass state, CP
conservation and U_{e3} either zero or proportional to R, where R is the ratio
of the solar and atmospheric \Delta m^2. Matrices containing 4 zeros can be
classified in categories predicting U_{e3} = 0, U_{e3} \neq 0 but no CP
violation or |U_{e3}| \neq 0 and possible CP violation. Some cases allow to set
constraints on the neutrino masses. The characteristic value of U_{e3} capable
of distinguishing some of the cases with non-trivial phenomenological
consequences is about R/2 \sin 2 \theta_{12}. Matrices containing 3 and less
zero entries imply (with a few exceptions) no correlation for the observables.
We outline models leading to the textures based on the Froggatt-Nielsen
mechanism or the non-Abelian discrete symmetry D_4 \times Z_2.Comment: 32 pages, 3 figures. Comments and references added. To appear in JHE
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