65 research outputs found
Standardizing the Fiscal State: Cabal Tax Farming as an Intermediate Institution in Early-Modern England and France
The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701
Philip C. Almond. Adam and Eve in Seventeenth-Century Thought. New York: Cambridge University Press. 1999. Pp. x, 240. $54. 95. ISBN 0-521-66076-9.
C. de C. Parmiter. The King's Great Matter: A Study of Anglo-Papal Relations 1527-1534. N. Y.: Barnes & Noble, 1967. $11.
The Bishops’ Wars. Charles l's campaigns against Scotland 1638–1640. By Mark Charles Fissel. (Cambridge Studies in Early Modern British History.) Pp. xvi + 336. Cambridge: Cambridge University Press, 1994. £40 (cloth), £17.95 (paper) .0 521 34520 0; 0 521 46686 5
A estrutura retórica do verbete Spinoza
Propomos uma análise do verbete "Spinoza" do Dictionnaire Historique et Critique salientando a estrutura retórica do texto, em cujo centro se encontra a nova figura do ateu, construÃda por Bayle, o ateu especulativo ou "o ateu de sistema".<br>The paper presents a study of the rhetorical framework of the article "Spinoza" in Bayle's Dictionnaire Historique et Critique and the new image of the atheist as athée de système
Simecs, Ithaca Hours, Berkshares, Bitcoins and Walmarts
The practical and theoretical meaning of the rise and fall of new local and virtual currencies suggest that two basic theories of money both have their validity and reasons for coexistence. The drive for increasing efficiency in the payment mechanisms is in full swing and still presents many opportunities for improvement
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