Thermal Stability of Type II Modifications Inscribed by Femtosecond Laser in a Fiber Drawn from a 3D Printed Preform

Fiber drawing from a 3D printed perform was recently discussed to go beyond the limitations of conventional optical fiber manufacturing in terms of structure and materials. In this work, the photosensitivity of silica optical fibers to femtosecond laser light, and fabricated by 3D printing a preform, is investigated. The writing kinetics and the thermal performance of Type II modifications are studied by varying the laser pulse energy and investigating the birefringence response of the femtosecond (fs)-laser written structures. Compared with a conventional telecom single mode fiber (SMF28), the fiber made by 3D printing is found to have similar writing kinetics and thermal performance. Additionally, the thermal stability of the imprinted fs-laser induced nanostructures is investigated based on the Rayleigh–Plesset equation, describing a model of nanopores dissolution underpinning Type II modifications with thermal annealing

Sexto reporte de eventos adversos con tratamientos biológicos en Argentina. Informe del registro BIOBADASAR

Objetivo: actualizar los resultados del registro BIOBADASAR sobre seguridad, duración y causas de interrupción del tratamiento luego de 8 años de seguimiento. Métodos: BIOBADASAR es un registro de seguridad de terapias biológicas establecido por la Sociedad Argentina de Reumatología. Se presenta la descripción de BIOBADASAR 3.0, una cohorte compuesta por 53 centros de Argentina seguidos prospectivamente desde agosto de 2010 hasta enero de 2018

Treatment of neuromyelitis optica with rituximab: a 2-year prospective multicenter study

International audienc

Metabotropic Glutamate Receptor Type 1 Autoantibody-Associated Cerebellitis A Primary Autoimmune Disease?

Objectives: To report the third case of subacute cerebellar ataxia associated with metabotropic glutamate receptor type 1 autoantibodies (mGluR1-Abs), an uncommon syndrome known to be part of the group of paraneoplastic cerebellar degeneration syndromes linked to antineuronal antibodies and previously reported in only 2 other patients with long-term remission of Hodgkin lymphoma, and to discuss the underlying immunopathogenesis. Design: Case report. Setting: University hospital. Patient: A 50-year-old woman admitted for acute severe isolated static and kinetic cerebellar syndrome. Magnetic resonance imaging of the brain showed diffuse abnormal hyperintensity in the whole cerebellum on fluid-attenuated inversion recovery and diffusion sequences. Results: Results of the biological workup were negative for general inflammation, vitamin deficiency, and bacterial and viral infections. Immunohistochemical analysis of the serum and cerebrospinal fluid of the patient demonstrated staining for Purkinje cell bodies and the molecular layer of the cerebellum. Finally, mGluR1-Abs were detected in serum and cerebrospinal fluid by a cell-based assay. Complete clinical examination, thoracoabdominal-pelvic computed tomography, and wholebody fludeoxyglucose F 18-positron emission tomography failed to show any underlying tumor, including Hodgkin lymphoma. The disease was stabilized after a course of intravenous immunoglobulins and continuous mycophenolate mofetil treatment during a follow-up of 40 months. Conclusions: Cerebellitis associated with mGluR1-Abs should be considered in the differential diagnosis of patients with subacute cerebellar ataxia. This first case without any tumor found suggests a possible idiopathic autoimmune rather than a paraneoplastic mechanism. In consideration of this possible primitive autoimmune ataxia involving the directly pathogenic mGluR1-Abs, immunoactive therapy should be initiated as early as possible

(INVITED)Investigation of intense visible defect luminescence from visible and infrared pumped barium fluorosilicate glass-core fiber

Optically active defects in silica have been studied for decades and are often indicators of network irregularities such as those that might result from optical or mechanical damage. They are well-known to be weak emitters and are usually present in relatively low concentration, thus precluding their use in a wide range of applications, including sensing and laser gain. Here, a new paradigm in intense defect emission in the visible wavelength range from a nominally passive optical fiber is presented. Optical fiber starting with 100 mol % BaF2 precursor core material and a pure silica cladding was successfully drawn utilizing the molten core method. These fibers demonstrate an intense, yet unexpected, green photoluminescence peaking near 537 nm (in addition to a second, weaker band near 704 nm) arising from relatively low-power CW pumping in the near-infrared at 976 nm. To understand the origins of this emission, absorption across the optical spectrum is analyzed and photoluminescence via excitation in both the visible and near-infrared wavelength ranges is studied. In addition, Raman spectra, decay lifetimes, magnetization curves, and temperature dependence measurements were collected. The emission spectra maintained a Pekarian-like spectral shape, suggesting an optically active defect as the mechanism behind the green emission. The results presented herein point towards the most likely origin being silanone or dioxasilyrane groups usually associated with surface defects. Importantly, such fibers, fabricated through less conventional methods and possessing novel compositions, may prove to be key in further extending the range of possibilities in defect engineering to well beyond what was previously thought possible

Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages

International audienc