Resistant arterial hypertension in a patient with adrenal incidentaloma multiple steno-obstructive vascular lesions and antiphospholipid syndrome

Resistant hypertension is defined as above of blood pressure (≤ 140/90 mmHg) despite therapy with three or more antihypertensive drugs of different classes at maximum tolerable doses with one bling a diuretic. An important consideration in defining a patient with resistant hypertension is the mislabeling of secondary hypertension as resistant hypertension. Here, we report a patients with resistant hypertension caused by multiple stenoocclusive arteries due to antiphospholipid syndrome and coexisting with subclinical Cushing’s syndrome

Bioarchaeology of Life and Death in Tuscany, Italy, AD 900–1900

Human remains from archaeological contexts provide a fund of information for addressing questions and hypotheses about what life was like in the past. These remains are especially important because they represent the individual and their life experiences from early childhood through adulthood, and especially those experiences relating to health and lifestyle. This paper presents an overview of health indicators documented in an ongoing bioarchaeological project involving the study of remains of people interred at the church of San Pietro a Pozzeveri, located near the village of Badia Pozzeveri in the province of Tuscany, northern Italy. Founded in the 11th century A.D., the church was in continuous existence until the mid-20th century. The church was part of a monastery during the 12th through 14th centuries, and was located on the Via Francigena, a strategic trade and pilgrimage route connecting Canterbury, England, with Rome. Archaeological excavations have produced numerous skeletons from the medieval, Renaissance, and modern (17th to 19th centuries) periods. Key events that impacted the people living in this region included the Black Death, which swept through Europe in the medieval period, and the local record of the global cholera epidemic in the mid-19th century. Study of skeletal and dental pathology (osteoperiostitis, osteoarthritis, dental caries), trauma, and other evidence of living conditions reveals the hardships of life in this setting. The record of infection and poor oral health speaks to both the poor circumstances of diet, including a focus on dietary carbohydrates, and poor health generally in the region in particular and Europe in general during this thousand-year period of history

A higher Angiogenin expression is associated with a non-nuclear Maspin location in laryngeal carcinoma

Objectives. In numerous malignancies, angiogenin (ANG) and Maspin are important proangiogenic and antiangiogenic regulators, respectively. The aim of this study was to identify potential relationships between the biological roles of these two proteins in laryngeal squamous cell carcinoma (LSCC). Methods. Immunohistochemical staining for ANG and Maspin was performed on specimens from 76 consecutive LSCC patients treated with surgery alone, considering the subcellular pattern of Maspin expression. Univariate and multivariate statistical models were used for prognostic purposes. Results. On univariate analysis, a different level of ANG expression was seen for patients stratified by subcellular Maspin expression pattern: the mean ANG expression was higher in cases with a nonnuclear MASPIN expression than in those with a nuclear pattern (P=0.002). Disease-free survival (DFS; in months) differed significantly when patients were stratified by N stage (P=0.01). Patients whose Maspin expression was nonnuclear (i.e., it was cytoplasmic or there was none) had a significantly higher recurrence rate (P<0.001), and shorter DFS (P=0.01) than those with a nuclear Maspin pattern. The mean ANG expression was significantly higher in cases with loco-regional recurrent disease (P=0.007); and patients with an ANG expression 655.0% had a significantly shorter DFS than those with an ANG expression <5.0% (P=0.007). On multivariate analysis, ANG expression 655.0% was a significant, independent, negative prognostic factor in terms of DFS (P=0.041). Conclusion. Our results support the hypothesis that a higher ANG expression is associated with a nonnuclear Maspin expression pattern in patients with LSCC. Further studies are needed to clarify the relationship between the ANG and Maspin pathways, and their potential diagnostic and therapeutic role in LSCC

Assessment of an Existing Prestressed R.C. Bridge According to fib Bulletin 80

Fib Bulletin 80 proposes twomethods for the recalibration of the partial safety factors specific for existing reinforced concrete structures and infrastructures taking into account different issues: the residual service life, information deriving from tests, measurements of variable actions and lower target reliability according to economical and human safety criteria. The methods presented in fib Bulletin 80 have been used to assess an existing prestressed concrete bridge built in the 90s. Successively, the results are compared to the outcomes achieved using the approach of EN1990

Role of Reactive Oxygen Species in the Neural and Hormonal Regulation of the PNMT Gene in PC12 Cells

The stress hormone, epinephrine, is produced predominantly by adrenal chromaffin cells and its biosynthesis is regulated by the enzyme phenylethanolamine N-methyltransferase (PNMT). Studies have demonstrated that PNMT may be regulated hormonally via the hypothalamic-pituitary-adrenal axis and neurally via the stimulation of the splanchnic nerve. Additionally, hypoxia has been shown to play a key role in the regulation of PNMT. The purpose of this study was to examine the impact of reactive oxygen species (ROS) produced by the hypoxia mimetic agent CoCl2, on the hormonal and neural stimulation of PNMT in an in vitro cell culture model, utilizing the rat pheochromocytoma (PC12) cell line. RT-PCR analyses show inductions of the PNMT intron-retaining and intronless mRNA splice variants by CoCl2 (3.0- and 1.76-fold, respectively). Transient transfection assays of cells treated simultaneously with CoCl2 and the synthetic glucocorticoid, dexamethasone, show increased promoter activity (18.5-fold), while mRNA levels of both splice variants do not demonstrate synergistic effects. Similar results were observed when investigating the effects of CoCl2-induced ROS on the neural stimulation of PNMT via forskolin. Our findings demonstrate that CoCl2-induced ROS have synergistic effects on hormonal and neural activation of the PNMT promoter

B_{s,d} -> l^+ l^- and K_L -> l^+ l^- in SUSY models with non-minimal sources of flavour mixing

We present a general analysis of B_{s,d}-> l^+ l^- and K_L -> l^+ l^- decays in supersymmetric models with non-minimal sources of flavour mixing. In spite of the existing constraints on off-diagonal squark mass terms, these modes could still receive sizeable corrections, mainly because of Higgs-mediated FCNCs arising at large tan(beta). The severe limits on scenarios with large tan(beta) and non-negligible {tilde d}^i_{R(L)}-{d-tilde}^j_{R(L)} mixing imposed by the present experimental bounds on these modes and Delta B=2 observables are discussed in detail. In particular, we show that scalar-current contributions to K_L -> l^+ l^- and B-{bar B} mixing set non-trivial constraints on the possibility that B_s -> l^+ l^- and B_d -> l^+ l^- receive large corrections.Comment: 18 pages, 4 figures (v2: minor changes, published version

On the Standard Model prediction for BR(B{s,d} to mu+ mu-)

The decay Bs to mu+ mu- is one of the milestones of the flavor program at the LHC. We reappraise its Standard Model prediction. First, by analyzing the theoretical rate in the light of its main parametric dependence, we highlight the importance of a complete evaluation of higher-order electroweak corrections, at present known only in the large-mt limit, and leaving sizable dependence on the definition of electroweak parameters. Using insights from a complete calculation of such corrections for K to pi bar{nu} nu decays, we find a scheme in which NLO electroweak corrections are likely to be negligible. Second, we address the issue of the correspondence between the initial and the final state detected by the experiments, and those used in the theoretical prediction. Particular attention is devoted to the effect of the soft radiation, that has not been discussed for this mode in the previous literature, and that can lead to O(10%) corrections to the decay rate. The "non-radiative" branching ratio (that is equivalent to the branching ratio fully inclusive of bremsstrahlung radiation) is estimated to be (3.23 +/- 0.27) x 10^{-9} for the flavor eigenstate, with the main uncertainty resulting from the value of f_{Bs}, followed by the uncertainty due to higher order electroweak corrections. Applying the same strategy to Bd to mu+ mu-, we find for its non-radiative branching ratio (1.07 +/- 0.10) x 10^{-10}.Comment: 15 pages. v3: very minor changes to match the journal version (EPJC