Bio-based building components: A newly sustainable solution for traditional walls made of Arundo donax and gypsum

To contribute to the use of bio-based materials in the building sector, a novel bio-based wall panel, with a high thermal performance level, is proposed in this work. The panel is based on an ancient rural technique, widely diffused in southern Italy, which makes use of Arundo donax L. canes combined with gypsum plaster to build walls and ceilings of rural buildings. The enhancement of the thermal capacity of these panels by means of the introduction in the canes of a natural wax oleogel (WO) is proposed in this paper. A specific experimental campaign aiming at the comparison of traditional and innovative panels was carried out to assess the enhanced thermal performance of the proposed solution. The maximum value of heat flow absorbed from the panel with WO was 61.08 W/m(2) around a mean panel temperature of 24 & DEG;C, corresponding to the melting temperature range of the WO. The panel without WO at the same temperature absorbed an incoming heat flow of 34.64 W/m(2) which is about 57% of the panel with WO. The panel with WO released at a temperature of about 27.5 & DEG;C, a heat flow of 43.42 W/m(2). At the same temperature of about 27.5 & DEG;C, the panel without WO released a heat flow of 34.38 W/m(2) which is about 80% that of the panel with WO. The results highlighted that the addition of natural WO has enhanced the thermal capacity of the panel facilitating heat dissipation through the borders. These characteristics make the panel a suitable component for internal partitions of controlled temperature zones such as residential rooms, storage food areas, livestock buildings, and where it is necessary to obtain a constant environmental temperature. In particular, the null or low toxicity of the panel's materials allows for partition use, also in hygienically safe environments

Safety performance assessment of food industry facilities using a fuzzy approach

The latest EU policies focus on the issue of food safety with a view to assuring adequate and standard quality levels for the food produced and/or consumed within the EC. To that purpose, the environment where agricultural products are manufactured and processed plays a crucial role in achieving food hygiene. As a consequence, it is of the utmost importance to adopt proper building solutions which meet health and hygiene requirements and to use suitable tools to measure the levels achieved. Similarly, it is necessary to verify and evaluate the level of safety and welfare of the workers in their working environment. The safety of the workers has not only an ethical and social value but also an economic implication, since possible accidents or environmental stressors are the major causes of the lower efficiency and productivity of workers. However, the technical solutions adopted in the manufacturing facilities in order to achieve adequate levels of safety and welfare of the workers are not always consistent with the solutions aimed at achieving adequate levels of food hygiene, even if both of them comply with sectoral rules which are often unconnected with each other. Therefore, it is fundamental to design suitable models of analysis that allow assessing buildings as a whole, taking into account both health and hygiene safety as well as the safety and welfare of workers. Hence, this paper proposes an evaluation model that, based on an established study protocol and on the application of a fuzzy logic procedure, allows evaluating the global safety level of a building. The proposed model allows to obtain a synthetic and global value of the building performance in terms of food hygiene and safety and welfare of the workers as well as to highlight possible weaknesses. Though the model may be applied in either the design or the operational phase of a building, this paper focuses on its application to certain buildings already operational in a specific productive context

Rapamycin-loaded polymeric nanoparticles as an advanced formulation for macrophage targeting in atherosclerosis

Recently, rapamycin (Rapa) represents a potential drug treatment to induce regression of atherosclerotic plaques; however, its use requires site-specific accumulation in the vessels involved in the formation of the plaques to avoid the systemic effects resulting from its indiscriminate biodistribution. In this work, a stable pharmaceutical formulation for Rapa was realized as a dried powder to be dispersed extemporaneously before administration. The latter was constituted by man-nitol (Man) as an excipient and a Rapa-loaded polymeric nanoparticle carrier. These nanoparticles were obtained by nanoprecipitation and using as a starting polymeric material a polycaprolactone (PCL)/α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) graft copolymer. To obtain nanoparti-cles targeted to macrophages, an oxidized phospholipid with a high affinity for the CD36 receptor of macrophages, the 1-(palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine (KOdia-PC), was added to the starting organic phase. The chemical–physical and technological characterization of the obtained nanoparticles demonstrated that: both the drug loading (DL%) and the entrapment efficiency (EE%) entrapped drug are high; the entrapped drug is in the amorphous state, protected from degradation and slowly released from the polymeric matrix; and the KOdia-PC is on the nanoparticle surface (KP-Nano). The biological characterization demonstrated that both systems are quickly internalized by macrophages while maintaining the activity of the drug. In vitro studies demonstrated that the effect of KP-Nano Rapa-loaded, in reducing the amount of the Phospo-Ser757-ULK1 protein through the inhibition of the mammalian target of rapamycin (mTOR), is comparable to that of the free drug

Recent activity and kinematics of the bounding faults of the Catanzaro trough (Central Calabria, italy): new morphotectonic, geodetic and seismological data

A multidisciplinary work integrating structural, geodetic and seismological data was performed in the Catanzaro Trough (central Calabria, Italy) to define the seismotectonic setting of this area. The Catanzaro Trough is a structural depression transversal to the Calabrian Arc, lying in-between two longitudinal grabens: the Crati Basin to the north and the Mesima Basin to the south. The investigated area experienced some of the strongest historical earthquakes of Italy, whose seismogenic sources are still not well defined. We investigated and mapped the major WSW–ENE to WNW–ESE trending normal-oblique Lamezia-Catanzaro Fault System, bounding to the north the Catanzaro Trough. Morphotectonic data reveal that some fault segments have recently been reactivated since they have displaced upper Pleistocene deposits showing typical geomorphic features associated with active normal fault scarps such as triangular and trapezoidal facets, and displaced alluvial fans. The analysis of instrumental seismicity indicates that some clusters of earthquakes have nucleated on the Lamezia-Catanzaro Fault System. In addition, focal mechanisms indicate the prevalence of left-lateral kinematics on E–W roughly oriented fault plains. GPS data confirm that slow left-lateral motion occurs along this fault system. Minor north-dipping normal faults were also mapped in the southern side of the Catanzaro Trough. They show eroded fault scarps along which weak seismic activity and negligible geodetic motion occur. Our study highlights that the Catanzaro Trough is a poliphased Plio-Quaternary extensional basin developed early as a half-graben in the frame of the tear-faulting occurring at the northern edge of the subducting Ionian slab. In this context, the strike-slip motion contributes to the longitudinal segmentation of the Calabrian Arc. In addition, the high number of seismic events evidenced by the instrumental seismicity, the macroseismic intensity distribution of the historical earthquakes and the scaling laws relating to earthquakes and seismogenic faults support the hypothesis that the Lamezia-Catanzaro Fault System may have been responsible for the historical earthquakes since it is capable of triggering earthquakes with magnitude up to 6.9

Seismotectonics of the active thrust front in southwestern Sicily: hints on the Belice and Selinunte seismogenic sources

We present a seismotectonic model of the active thrust front in western Sicily, which includes the area hit by the 1968 Belice earthquake sequence. The ~40 km long South-WEstern Sicilian Thrust (SWEST) is formed by two aligned albeit non-parallel fault arrays, the Granitola-Castelevetrano Thrust System (GCTS) in the west and the Partanna- Poggioreale Thrust System (PPTS) in the east. The ~NE-SW trending, NW-dipping GCTS straddles from the Pelagian coastline to Castelvetrano, is ~18 km long and composed of two segments, with the northern, ~12 km long one showing geodetic and geologic evidence of active deformation (Barreca et al., 2014). The segment is marked by a sharp gradient in Differential SAR interferometry (DinSAR and STAMPs) and GPS velocity fields. Geologic evidence include an up to 60 m high, and up to 15° steep scarp, which is the fore-limb of a broad fold involving Lower Pleistocene shore calcarenites, and cm-scale reverse displacement of an ancient road dated as early Bronze-Hellenistic age. Inversion of fault slip-lineation data from structures displacing the archaeological remains yields a ~N110°E shortening axis, consistent with the geodetic shortening direction estimated from GPS differential velocities. The ~ENE-WSW trending PPTS stretches from Partanna to the macro-seismic area of the 1968 earthquake sequence and is composed of two ~10 km long segments limited by relay ramps. Although geologic and geodetic evidence of deformation are less clear than for the GCTS, we nonetheless observe a gradient in interferometry data for the western segment, and evidence of slow deformation (creep?) in historical to recent (last ~400 yr?) man-made structures. Integration of geologic, geodetic and seismology data suggests the active folds and thrusts are the uppermost expression of steep (45°) crustal ramps (Monaco et al., 1996) which upthrust the Saccense platform at depth. Based on macroseismic and seismological evidence (Monaco et al., 1996), we contend that the PPTS was partly activated during the 1968 sequence, and that rupture stopped at the junction with the GCTS. The current geodetic strain accumulation on the GCTS, on the other hand, suggests that the fault array has been significantly loaded, and that its last important co-seismic event could have been caused the 4th–5th century A.D. destruction of Selinunte (Bottari et al., 2009)