15 research outputs found
Domain wall fermion zero modes on classical topological backgrounds
The domain wall approach to lattice fermions employs an additional dimension,
in which gauge fields are merely replicated, to separate the chiral components
of a Dirac fermion. It is known that in the limit of infinite separation in
this new dimension, domain wall fermions have exact zero modes, even for gauge
fields which are not smooth. We explore the effects of finite extent in the
fifth dimension on the zero modes for both smooth and non-smooth topological
configurations and find that a fifth dimension of around ten sites is
sufficient to clearly show zero mode effects. This small value for the extent
of the fifth dimension indicates the practical utility of this technique for
numerical simulations of QCD.Comment: Updated fig. 3-7, small changes in sect. 3, added fig. 8, added more
reference
Genetic analysis of nucleotide sequences of neuraminidase gene of highly pathogenic avian influenza A/H5N8 virus isolates recovered in the Russian Federation in 2020
Avian influenza is a highly dangerous viral disease that causes huge economic damage to poultry farming. Currently, highly virulent influenza virus with N8 neur- aminidase subtype is quite often detected in populations of domestic and wild birds in various countries of the world. The article provides data on complete nucleotide sequences of the neuraminidase gene of highly pathogenic avian influenza virus isolates recovered in the second half of 2020 from pathological material received from four regions of the Russian Federation. The conducted research showed that the subtype of the isolated virus was N8. According to the phylogenetic analysis, isolates of N8 virus belong to group 8C.4. During the phylogenetic analysis of the neuraminidase, we also took into account data on hemagglutinin classification, according to which H5N8 virus isolates belong to a widespread clade 2.3.4.4. Viruses of the clade were first registered in 2010 in China and they have been circulating up to now. The paper also provides data of a comparative analysis of nucleotide sequences of the studied isolates and the isolates from the international GenBank and GISAID databases, recovered in other countries from 2007 to 2020. During the analysis of the amino acid sequence of the studied isolates, no substitutions were found in the positions that affect resistance to neuraminidase inhibitors. The complete nucleotide sequences of the neuraminidase gene of the avian influenza virus subtype N8 (isolates A/domestic goose/OMSK/1521-1/2020, A/duck/Chelyabinsk/1207-1/2020, A/duck/Saratov/1578-2/2020, A/goose/Tatarstan/1730-2/2020) are published in the international GenBank and GISAID databases. Based on the analysis of the nucleotide sequences of the studied isolates, the article shows gradual evolution of the N8 subtype virus
Non-perturbative Renormalisation of Domain Wall Fermions: Quark Bilinears
We find the renormalisation coefficients of the quark field and the flavour
non-singlet fermion bilinear operators for the domain wall fermion action, in
the regularisation independent (RI) renormalisation scheme. Our results are
from a quenched simulation, on a 16^3x32 lattice, with beta=6.0 and an extent
in the fifth dimension of 16. We also discuss the expected effects of the
residual chiral symmetry breaking inherent in a domain wall fermion simulation
with a finite fifth dimension, and study the evidence for both explicit and
spontaneous chiral symmetry breaking effects in our numerical results. We find
that the relations between different renormalisation factors predicted by
chiral symmetry are, to a good approximation, satisfied by our results and that
systematic effects due to the (low energy) spontaneous chiral symmetry breaking
and zero-modes can be controlled. Our results are compared against the
perturbative predictions for both their absolute value and renormalisation
scale dependence.Comment: 53 pages, 21 figures, revte
The finite temperature QCD phase transition with domain wall fermions
The domain wall formulation of lattice fermions is expected to support
accurate chiral symmetry, even at finite lattice spacing. Here we attempt to
use this new fermion formulation to simulate two-flavor, finite temperature QCD
near the chiral phase transition. In this initial study, a variety of quark
masses, domain wall heights and domain wall separations are explored using an
8^3 x 4 lattice. Both the expectation value of the Wilson line and the chiral
condensate show the temperature dependence expected for the QCD phase
transition. Further, the desired chiral properties are seen for the chiral
condensate, suggesting that the domain wall fermion formulation may be an
effective approach for the numerical study of QCD at finite temperature.Comment: 44 pages, 15 figure
Quenched Lattice QCD with Domain Wall Fermions and the Chiral Limit
Quenched QCD simulations on three volumes, , and
and three couplings, , 5.85 and 6.0 using domain
wall fermions provide a consistent picture of quenched QCD. We demonstrate that
the small induced effects of chiral symmetry breaking inherent in this
formulation can be described by a residual mass (\mres) whose size decreases
as the separation between the domain walls () is increased. However, at
stronger couplings much larger values of are required to achieve a given
physical value of \mres. For and , we find
\mres/m_s=0.033(3), while for , and ,
\mres/m_s=0.074(5), where is the strange quark mass. These values are
significantly smaller than those obtained from a more naive determination in
our earlier studies. Important effects of topological near zero modes which
should afflict an accurate quenched calculation are easily visible in both the
chiral condensate and the pion propagator. These effects can be controlled by
working at an appropriately large volume. A non-linear behavior of in
the limit of small quark mass suggests the presence of additional infrared
subtlety in the quenched approximation. Good scaling is seen both in masses and
in over our entire range, with inverse lattice spacing varying between
1 and 2 GeV.Comment: 91 pages, 34 figure
Базисная терапия тяжелой бронхиальной астмы у взрослых. Данные национального исследования НАБАТ
The study was aimed to Investigate severe asthma therapy in Russia. It involved 515 patients from 7 Russian cities according to the criteria of severe asthma. Individual registration cards were filled in considering dem ographic data, principal clinical features, drug therapy. It has been found that both inpatient and outpatient therapy of severe asthm a in Russia does not correspond to the standards recommended. The results confirmed high efficiency of inhaled corticosteroids when combined with long-acting β2-agonists. This therapy was found to be more effective then other regarding to symptoms, lung function param eters, rate of admission to a hospital and duration of hospital staying. Patients treated with this drug combination were satisfied by the treatment more often.Исследование проведено с целью изучения особенностей терапии тяжелой бронхиальной астмы (БА) в России. В соответствии с использовавшимися критериями тяжелой БА в исследование были включены 515 больных в 7 городах России. В каждом центре заполнялись индивидуальные регистрационные карты, при этом учитывались демографические характеристики пациента, основные аспекты клинического течения заболевания, мониторирования, фармакотерапии. Было обнаружено, что терапия тяжелой астмы в России, как на стационарном, так и на амбулаторном этапах, не соответствует рекомендованным стандартам. Результаты исследования еще раз подтверждают высокую эффективность применения комбинации ингаляционных кортикостероидов и длительнодействующих β2-агонистов. Данный вид терапии оказался эффективнее других вариантов в отношении симптомов, функции легких, частоты госпитализаций и их длительности, а пациенты, совместно получавшие ингаляционные кортикостероиды и длительнодействующие β2-агонистов были в гораздо большем количестве случаев удовлетворены лечением
Possibilities to prevent acute exacerbation of chronic obstructive pulmonary disease using inhalational therapy. A Report of Expert Panel of Russian Respiratory Society
Computational and experimental investigation of nonstationary heat transfer at a critical point
Analysis of marker substitutions in A/chicken/Astrakhan/2171-1/2020 H5N8 isolate of avian influenza virus recovered in the Astrakhan Oblast
At the end of 2020, a large-scale bird death was registered at one of the poultry farms in the Astrakhan region, the cause of which was avian influenza. Data on detection of the marker substitutions in viral proteins of avian influenza virus A/chicken/Astrakhan/2171-1/2020 isolate are presented in the paper. Type A Н5N8 avian influenza virus was identified with complex PCR-based methods in the submitted samples. Hemagglutinin gene fragment sequencing identified REKRRKR/ GLF, highly pathogenic avian influenza virus isolate-characteristic amino acid sequence of the hemagglutinin cleavage site. Phylogenetic analysis of nucleotide sequences of hemagglutinin gene segment (848–1105 bp ORF) allowed A/chicken/Astrakhan/2171-1/2020 H5N8 isolate to be classified to highly pathogenic avian influenza virus genetic clade 2.3.4.4. Comparative analysis of genome segments using available databases showed that A/chicken/Astrakhan/2171-1/2020 H5N8 virus related to А/Н5 avian influenza virus isolates detected in the Russian Federation in 2016–2020. Analysis of the studied virus isolate hemagglutinin amino acid identified AIV-characteristic G225QRG228 amino acids in the receptor-binding domain of the protein enabling high-affinity binding to avian epithelial cell SAα-2,3- gal receptors. Single mutations, 70G in NEP protein and 13Р in PB1 protein, out of the list of the reported influenza virus mutations affecting successful influenza virus replication in mammals were identified. No mutations affecting virus sensitivity to anti-viral medicines, rimantadin, amantadine, oseltamivir and zanamivir, were detected. The following mutations recognized as pathogenicity determinants in mice were found: 42S in the NS1 protein and 30D protein 215A in M1 protein