Positive solutions for singularly perturbed nonlinear elliptic problem on manifolds via Morse theory

Given (M, g0) we consider the problem -{\epsilon}^2Delta_{g0+h}u + u = (u+)^{p-1} with ({\epsilon}, h) \in (0, {\epsilon}0) \times B{\rho}. Here B{\rho} is a ball centered at 0 with radius {\rho} in the Banach space of all Ck symmetric covariant 2-tensors on M. Using the Poincar\'e polynomial of M, we give an estimate on the number of nonconstant solutions with low energy for ({\epsilon}, h) belonging to a residual subset of (0, {\epsilon}0) \times B{\rho}, for ({\epsilon}0, {\rho}) small enough

L’eroe mangia: il pasto nella dimensione della hybris eroica

Sin resume

I Suoli su substrati acidi in Sardegna: nota 4.: i suoli del Massiccio dei Sette Fratelli

The Authors present the results of a pedological study on Sette Fratelli relief (Sud-East Sardlnia). Lithic Xerothents are the principal soils in upslope positons and steepness of the slope control their development. Lithic and Typic Xerochrepts are the typic soils of remaining area and vegetation help their development. High base content is one of the most interesting characteristic in these soils

I Suoli su substrati acidi in Sardegna: nota 2.: i suoli del versante nord-ovest del Massiccio del Limbara

Factors of soils formation of the NW-facing slopes of Limbara relief are described. The climatic factor is considered to be the most important factor in determining the properties of soils in upslope positions (1300-1100 m). The principal soils are Lithie Haplumbrepts. The morphology and vegetation help the development of the soils between 1100 and 800 m. They are Typic Xerumbrepts. Between 800 and 500 m the principal soils are Lithic Xerorthents. Steepness of the slope controls their development

A metaphor for the group analysis

The clinical practice and the theoretic elaboration are two activities that require a clear epistemological framework, a methodological severity and also a suitable integration with the mythopoeic aspects of human existence. With particular reference to these last, the article suggests some considerations useful for the comprehension of the group therapeutic experience, through the allegorical use of the features, and the historical and mythical vicissitude of the Mediterranean Sea. Sea that, thanks to its morphological climatic characteristics, as well as to its evocative faculties give us some starting points for thinking about the therapeutic work in the long term groups

Treatment of atherosclerotic renovascular hypertension: review of observational studies and a meta-analysis of randomized clinical trials.

open9Atherosclerotic renal artery stenosis can cause ischaemic nephropathy and arterial hypertension. We herein review the observational and randomized clinical trials (RCTs) comparing medical and endovascular treatment for control of hypertension and renal function preservation. Using the Population Intervention Comparison Outcome (PICO) strategy, we identified the relevant studies and performed a novel meta-analysis of all RCTs to determine the efficacy and safety of endovascular treatment when compared with medical therapy. The following outcomes were examined: baseline follow-up difference in mean systolic and diastolic blood pressure (BP), serum creatinine, number of drugs at follow-up, incident events (heart failure, stroke, and worsening renal function), mortality, cumulative relative risk of heart failure, stroke, and worsening renal function. Seven studies comprising a total of 2155 patients (1741 available at follow-up) were considered, including the recently reported CORAL Study. Compared with baseline, diastolic BP fell more at follow-up in patients in the endovascular than in the medical treatment arm (standard difference in means -0.21, 95% confidence interval (CI): -0.342 to -0.078, P = 0.002) despite a greater reduction in the mean number of antihypertensive drugs (standard difference in means -0.201, 95% CI: -0.302 to -0.1, P < 0.001). At variance, follow-up changes (from baseline) of systolic BP, serum creatinine, and incident cardiovascular event rates did not differ between treatment arms. Thus, patients with atherosclerotic renal artery stenosis receiving endovascular treatment required less anti-antihypertensive drugs at follow-up than those medically treated. Notwithstanding this, they evidenced a better control of diastolic BP.openopenCaielli P;Frigo AC;Pengo MF;Rossitto G;Maiolino G;Seccia TM;Calò LA;Miotto D;Rossi GPCaielli, P; Frigo, ANNA CHIARA; Pengo, Mf; Rossitto, G; Maiolino, G; Seccia, TERESA MARIA; Calò, La; Miotto, Diego; Rossi, Gianpaol

Nuclear receptors and other nuclear transcription factors in mitochondria: Regulatory molecules in a new environment

AbstractThe mitochondrion is the major energy generating organelle of the cell and the site of other basic processes, including apoptosis. The mitochondrial functions are performed in concert with other cell compartments and are regulated by various extracellular and intracellular signals. Several nuclear receptors and other nuclear transcription factors, such as NF-κB, AP-1, CREB and p53, involved in growth, metabolic and developmental processes, have been detected in mitochondria. This finding raises the question as to the role of these regulatory molecules in their “new” environment. Experimental evidence supports the action of the mitochondrially localized transcription factors on mitochondrial transcription, energy yield and apoptosis, extending the known nuclear role of these molecules outside the nucleus. A principle of coordination of nuclear and mitochondrial gene transcription has been ascertained as regards the regulatory action of steroid and thyroid hormones on energy yield. Accordingly, the same nuclear receptors, localized in the two compartments–nuclei and mitochondria–regulate transcription of genes serving a common function by way of interaction with common binding sites in the two genomes. This principle is now expanding to encompass other nuclearly and mitochondrially localized transcription factors