An Investigation of Corona Domination Number for Some Special Graphs and Jahangir Graph

    في هذا العمل ، نستمر في دراسة هيمنة الاكليل في الرسوم البيانية التي تم اقتراحها لأول مرة في  بواسطة جي ماهاديفان  وجميع الآخرين. لنكن رسم بياني بسيط. يقال أن المجموعة المسيطرة S من الرسم البياني هي مجموعة تهيمن على الاكليل إذا كان كل قمة في قمة قلادة أو قمة دعم. يسمى الحد الأدنى من الأصالة بين جميع مجموعات الهيمنة على الاكليل برقم الهيمنة كورونا ويشار إليه بـ (i.e  هي مجموعة أقراص مضغوطة  منمن H}.  في هذا العمل ، قدمنا القيمة الدقيقة لرقم هيمنة الاكليل لبعض أنواع معينة من الر البيانية أن. أيضًا ، حصلنا على بعض النتائج على رقم هيمنة الاكليل لبعض فئات الرسوم البيانية والطريقة المستخدمة في هذه الورقة هي مفهوم نظرية الأعداد المعروف مع بعض التعديلات يمكن أيضًا تطبيق هذه الطريقة للحصول على النتائج على معلمات الهيمنة الأخرى.In this work,  the study of corona domination in graphs is carried over which was initially proposed by G. Mahadevan et al. Let be a simple graph. A dominating set S of a graph is said to be a corona-dominating set if every vertex in is either a pendant vertex or a support vertex. The minimum cardinality among all corona-dominating sets is called the corona-domination number and is denoted by (i.e) . In this work, the exact value of the corona domination number for some specific types of graphs are given. Also, some results on the corona domination number for some classes of graphs are obtained and the method used in this paper is a well-known number theory concept with some modification this method can also be applied to obtain the results on other domination parameters

Exploration of CPCD number for power graph

في الآونة الأخيرة ، تم تقديم هيمنة الإكليل المثالية التكميلية في الرسوم البيانية.يقال إن المجموعة المهيمنة S من الرسم البياني G هي مجموعة مهيمنة كاملة على الهالة (CPCD - مجموعة) إذا كان كل رأس في <S> إما رأس معلق أو رأس دعم <V-S> وله تطابق تام. يطلق على الحد الأدنى من الكاردينالية لمجموعة الإكليل المثالية التكميلية المهيمنة رقم هيمنة الإكليل المثالي التكميلي ويرمز له ب .في هذه الورقة ، تمت مناقشة معلمتنا للرسوم البيانية للطاقة للمسار والدورة.Recently, complementary perfect corona domination in graphs was introduced. A dominating set S of a graph G is said to be a complementary perfect corona dominating set (CPCD – set) if each vertex in  is either a pendent vertex or a support vertex and  has a perfect matching. The minimum cardinality of a complementary perfect corona dominating set is called the complementary perfect corona domination number and is denoted by . In this paper, our parameter hasbeen discussed for power graphs of path and cycle

Pattern of cutaneous adverse drug reactions at a tertiary care hospital in southern India

Background: The objective of the study was to assess the pattern of cutaneous adverse drug reactions reported by active surveillance to the Pharmacovigilance center of a tertiary care hospital in southern india, and also to establish the drugs causing the same and observe the age wise and gender based incidence of such reactions.Methods: The cutaneous ADRs (CADRs) reported to the Pharmacovigilance center of the institution were analysed retrospectively during the period of March 2013 to December 2015. The various pattern of skin reactions and the most frequent drugs causing the same were established. An age wise and gender based incidence of CADRs and drugs causing them were also reported.Results: A total of 293 cases were taken for analysis. The male female ratio was 0.89-1.in our study. Among the age wise distribution of CADRs, 57(19.4%) were seen in paediatric, 194(66.2%) in adults and 33(11.2%) in geriatric age groups. The most frequent drugs to cause the CADRs were antimicrobials 183(62.4%) followed by NSAIDs 38(12.9%) and antacids 17(5.8%).Among the skin reactions urticaria/ angioedema was the most common 109(37.2%) followed by generalised pruritis 57(19.5%) and fixed drug eruption 37(12.6%). In all the age groups and both the sexes urticaria/angioedema and generalised pruritis were the leading skin reactions observed.Conclusions: As CADRs are the most common ADRs among others, it is prudent to monitor them closely, as any change in pattern with older or newer agents can alert the health care personnel in instituting the appropriate prescription patterns, which can overall impact the quality of health care positively

Outpatient prescription audit in a tertiary care hospital at Puducherry

Background: Rational use of medicines promotes good health practices and prevents inappropriate use of medicines, polypharmacy, unnecessary use of antimicrobials, injections, and also encourages use of medicines from essential medicine list and dispensing by generic names. The aim of the study was to analyze the outpatient prescriptions of a tertiary care centre by utilizing World Health Organization (WHO) core drug use prescribing indicators.Methods: A retrospective observational study was conducted in a tertiary care health setup at Puducherry, South India. Outpatient prescriptions from all the major clinical departments were analyzed using WHO prescribing indicators and they were compared with some similar studies.Results: The average number of drugs per prescription was 2.74. The percentage of prescriptions with antibiotics was 20.33% and the percentage of prescriptions with injections was 0.16%. The percentage of drugs prescribed by generic names and from essential medicine list was 83.13% and 87.9 respectively. Further antibiotic utilization was found to be higher in the department of ENT (56.67%), respiratory medicine (45%) and surgery (40%). Percentage of drugs prescribed by generic names in pediatrics and respiratory medicine were found to be 67.88% and 65.27% and percentage of drugs prescribed from essential medicine list in dermatology was 69.62%.Conclusions: Prescription pattern followed in our Institute almost adheres to the guidelines laid down by the WHO. Moreover, it is also implied that a routine audit of this type should be done in health care setups to ensure that they adhere to the WHO guidelines for better health care

Comparative shotgun proteomic analysis of Clostridium acetobutylicum from butanol fermentation using glucose and xylose

<p>Abstract</p> <p>Background</p> <p>Butanol is a second generation biofuel produced by <it>Clostridium acetobutylicum </it>through acetone-butanol-ethanol (ABE) fermentation process. Shotgun proteomics provides a direct approach to study the whole proteome of an organism in depth. This paper focuses on shotgun proteomic profiling of <it>C. acetobutylicum </it>from ABE fermentation using glucose and xylose to understand the functional mechanisms of <it>C. acetobutylicum </it>proteins involved in butanol production.</p> <p>Results</p> <p>We identified 894 different proteins in <it>C. acetobutylicum </it>from ABE fermentation process by two dimensional - liquid chromatography - tandem mass spectrometry (2D-LC-MS/MS) method. This includes 717 proteins from glucose and 826 proteins from the xylose substrate. A total of 649 proteins were found to be common and 22 significantly differentially expressed proteins were identified between glucose and xylose substrates.</p> <p>Conclusion</p> <p>Our results demonstrate that flagellar proteins are highly up-regulated with glucose compared to xylose substrate during ABE fermentation. Chemotactic activity was also found to be lost with the xylose substrate due to the absence of CheW and CheV proteins. This is the first report on the shotgun proteomic analysis of <it>C. acetobutylicum </it>ATCC 824 in ABE fermentation between glucose and xylose substrate from a single time data point and the number of proteins identified here is more than any other study performed on this organism up to this report.</p

HI in circumstellar environments

We present new results of a spectroscopic survey of circumstellar HI in the direction of evolved stars made with the Nancay Radiotelescope. The HI line at 21 cm has been detected in the circumstellar shells of a variety of evolved stars: AGB stars, oxygen-rich and carbon-rich, Semi-Regular and Miras, and Planetary Nebulae. The emissions are generally spatially resolved, i.e. larger than 4', indicating shell sizes of the order of 1 pc which opens the possibility to trace the history of mass loss over the past ~ 10^4-10^5 years. The line-profiles are sometimes composite. The individual components have generally a quasi-Gaussian shape; in particular they seldom show the double-horn profile that would be expected from the spatially resolved optically thin emission of a uniformly expanding shell. This probably implies that the expansion velocity decreases outwards in the external shells (0.1-1 pc) of these evolved stars. The HI line-profiles do not necessarily match those of the CO rotational lines. Furthermore, the centroid velocities do not always agree with those measured in the CO lines and/or the stellar radial velocities. The HI emissions may also be shifted in position with respect to the central stars. Without excluding the possibility of asymmetric mass ejection, we suggest that these two effects could also be related to a non-isotropic interaction with the local interstellar medium. HI was detected in emission towards several sources (rho Per, alpha Her, delta^2 Lyr, U CMi) that otherwise have not been detected in any radio lines. Conversely it was not detected in the two oxygen-rich stars with substantial mass-loss rate, NML Tau and WX Psc, possibly because these sources are young with hydrogen in molecular form, and/or because the temperature of the circumstellar HI gas is very low (< 5 K).Comment: Accepted for publication in The Astronomical Journa

Open Source Brain: A Collaborative Resource for Visualizing, Analyzing, Simulating, and Developing Standardized Models of Neurons and Circuits

Computational models are powerful tools for exploring the properties of complex biological systems. In neuroscience, data-driven models of neural circuits that span multiple scales are increasingly being used to understand brain function in health and disease. But their adoption and reuse has been limited by the specialist knowledge required to evaluate and use them. To address this, we have developed Open Source Brain, a platform for sharing, viewing, analyzing, and simulating standardized models from different brain regions and species. Model structure and parameters can be automatically visualized and their dynamical properties explored through browser-based simulations. Infrastructure and tools for collaborative interaction, development, and testing are also provided. We demonstrate how existing components can be reused by constructing new models of inhibition-stabilized cortical networks that match recent experimental results. These features of Open Source Brain improve the accessibility, transparency, and reproducibility of models and facilitate their reuse by the wider community

Intracellular protein determination using droplet-based immunoassays

This paper describes the implementation of a sensitive, on-chip immunoassay for the analysis of intracellular proteins, developed using microdroplet technology. The system offers a number of analytical functionalities, enabling the lysis of low cell numbers, as well as protein detection and quantification, integrated within a single process flow. Cells were introduced into the device in suspension and were electrically lysed in situ. The cell lysate was subsequently encapsulated together with antibody-functionalized beads into stable, water-in-oil droplets, which were stored on-chip. The binding of intracellular proteins to the beads was monitored fluorescently. By analyzing many individual droplets and quantifying the data obtained against standard additions, we measured the level of two intracellular proteins, namely, HRas-mCitrine, expressed within HEK-293 cells, and actin-EGFP, expressed within MCF-7 cells. We determined the concentrations of these proteins over 5 orders of magnitude, from 50 pM to 1 μM. The results from this semiautomated method were compared to those for determinations made using Western blots, and were found not only to be faster, but required a smaller number of cells