Subject-specific finite element modelling of the human hand complex : muscle-driven simulations and experimental validation

This paper aims to develop and validate a subject-specific framework for modelling the human hand. This was achieved by combining medical image-based finite element modelling, individualized muscle force and kinematic measurements. Firstly, a subject-specific human hand finite element (FE) model was developed. The geometries of the phalanges, carpal bones, wrist bones, ligaments, tendons, subcutaneous tissue and skin were all included. The material properties were derived from in-vivo and in-vitro experiment results available in the literature. The boundary and loading conditions were defined based on the kinematic data and muscle forces of a specific subject captured from the in-vivo grasping tests. The predicted contact pressure and contact area were in good agreement with the in-vivo test results of the same subject, with the relative errors for the contact pressures all being below 20%. Finally, sensitivity analysis was performed to investigate the effects of important modelling parameters on the predictions. The results showed that contact pressure and area were sensitive to the material properties and muscle forces. This FE human hand model can be used to make a detailed and quantitative evaluation into biomechanical and neurophysiological aspects of human hand contact during daily perception and manipulation. The findings can be applied to the design of the bionic hands or neuro-prosthetics in the future

A rapid cosmic-ray increase in BC 3372-3371 from ancient buried tree rings in China

Cosmic rays interact with the Earth's atmosphere to produce $^{14}$C, which can be absorbed by trees. Therefore, rapid increases of $^{14}$C in tree rings can be used to probe previous cosmic-ray events. By this method, three $^{14}$C rapidly increasing events have been found. Plausible causes of these events include large solar proton events, supernovae or short gamma-ray bursts. However, due to the lack of measurements of $^{14}$C by year, the occurrence frequency of such $^{14}$C rapidly increasing events is poorly known. In addition, rapid increases may be hidden in the IntCal13 data with five-year resolution. Here we report the result of $^{14}$C measurements using an ancient buried tree during the period between BC 3388 and 3358. We find a rapid increase of about 9\textperthousand~ in the $^{14}$C content from BC 3372 to BC 3371. We suggest that this event could originate from a large solar proton event.Comment: 23 pages, 3 figures, 2 tables, published in Nature Communication

Spin correlated interferometry for polarized and unpolarized photons on a beam splitter

Spin interferometry of the 4th order for independent polarized as well as unpolarized photons arriving simultaneously at a beam splitter and exhibiting spin correlation while leaving it, is formulated and discussed in the quantum approach. Beam splitter is recognized as a source of genuine singlet photon states. Also, typical nonclassical beating between photons taking part in the interference of the 4th order is given a polarization dependent explanation.Comment: RevTeX, 19 pages, 1 ps figure, author web page at http://m3k.grad.hr/pavici

The effects of β-elemene on the expression of mTOR, HIF-1α, surviving in lung adenocarcinoma A549 cell

The purpose of this manuscript was to study the regulation effects of  â-elemene combined with radiotherapy on three different gene expressions in lung adenocarcinoma A549 cell. mTOR gene, HIF-1á gene, Survivin gene were included in the gene group. Cell culture and RT-PCR were applied to finish this research. Hypoxia Control group, Hypoxia â-elemene group, Hypoxia â-elemene combined with irradiation group were set to compare the differences of three different gene expressions. The most active effects were found in the group of Hypoxia irradiation combined with â-elemene. In this group, the mTOR gene, HIF-1á gene, Survivin gene expressions were all down-regulated when compared with the single treatment groups, andthere were significantly statistical differences.Key words: â-elemene, A549, mTOR, HIF-1á, Survivin, Rhizoma Curcumae