A slot-loaded reduced-size CPW-fed aperture antenna for UWB applications

The paper presents a co-planar wave guide (CPW)-fed slot loaded low return loss planar printed antenna with a small size designed for wireless communication and UWB applications. First, a conventional UWB antenna is modeled to provide a reference point for the modeling and then the shape is modified by a self inverted configuration to achieve higher bandwidth and size reduction. To improve the gain and efficiency, a combination of corner features and loading slots are introduced. The primary aim throughout the modeling was to achieve the minimum possible value of return loss (S11) below -10 dB over the FCC-defined UWB frequency range. The antenna was designed, simulated and modified using Agilent's Advanced Design System (ADS). It was fabricated on FR4 substrate and measured return loss results are presented

Spectrum occupancy measurements and lessons learned in the context of cognitive radio

Various measurement campaigns have shown that numerous spectrum bands are vacant even though licenses have been issued by the regulatory agencies. Dynamic spectrum access (DSA) based on Cognitive Radio (CR) has been regarded as a prospective solution to improve spectrum utilization for wireless communications. Empirical measurement of the radio environment to promote understanding of the current spectrum usage of the different wireless services is the first step towards deployment of future CR networks. In this paper we present our spectrum measurement setup and discuss lessons learned during our measurement activities. The main contribution of the paper is to introduce global spectrum occupancy measurements and address the major drawbacks of previous spectrum occupancy studies by providing a unifying methodological framework for future spectrum measurement campaigns

Experimental detection using cyclostationary feature detectors for cognitive radios

© 2014 IEEE. Signal detection is widely used in many applications. Some examples include Cognitive Radio (CR) and military intelligence. Without guaranteed signal detection, a CR cannot reliably perform its role. Spectrum sensing is currently one of the most challenging problems in cognitive radio design because of various factors such as multi-path fading and signal to noise ratio (SNR). In this paper, we particularly focus on the detection method based on cyclostationary feature detectors (CFD) estimation. The advantage of CFD is its relative robustness against noise uncertainty compared with energy detection methods. The experimental result present in this paper show that the cyclostationary feature-based detection can be robust compared to energy-based technique for low SNR levels

Cooperative wideband spectrum sensing with multi-bit hard decision in cognitive radio

Cognitive radio offers an increasingly attractive solution to overcome the underutilization problem. A sensor network based cooperative wideband spectrum sensing is proposed in this paper. The purpose of the sensor network is to determine the frequencies of the sources and reduced the total sensing time using a multi-resolution sensing technique. The final result is computed by data fusion of multi-bit decisions made by each cooperating secondary user. Simulation results show improved performance in energy efficiency

Quality measurements of an UWB reduced-size CPW-fed aperture antenna

The paper presents a characterization of a compact co-planar waveguide (CPW)-fed slot loaded low return loss planar printed antenna designed for wireless communication and ultra-wideband (UWB) applications. Following a review of the antenna design, which was implemented and simulated using Agilent's Advanced Design System (ADS), the paper presents laboratory measurements of relative gain and impulse response transformed from the frequency domain. An antenna quality metric based on time-domain S21 is discussed and related to antenna quality metrics such as the System Fidelity Factor (SFF)

An Energy Feedback System for the MIT/Bates Linear Accelerator

We report the development and implementation of an energy feedback system for the MIT/Bates Linear Accelerator Center. General requirements of the system are described, as are the specific requirements, features, and components of the system unique to its implementation at the Bates Laboratory. We demonstrate that with the system in operation, energy fluctuations correlated with the 60 Hz line voltage and with drifts of thermal origin are reduced by an order of magnitude

Mercury bioaccumulation in pike (Esox lucius) from Anzali Lagoon, Iran

This paper presents the levels of total mercury (T-Hg) in dorsal muscle, liver and spleen of pike (Esox lucius) from Anzali Lagoon in Iran. Sampling was carried out from July 2004 to July 2005. In addition 78 samples were collected. T-Hg concentration was calculated in relation to biometric factors. T-Hg was measured by the LECO AMA 254 Advanced Mercury Analyzer (USA) according to ASTM standard NoD-6722. Each sample was analyzed 3 times. Accuracy of T-Hg analysis was checked by running three samples of Standard Reference Materials; SRM 1633b, SRM 2711 and SRM 2709. Detection limit was 0.001mg/kg in dry weight. The minimum and maximum concentration of T-Hg in dorsal muscle was 0.2 ppm in one year and 1.2 ppm in five year class. The mean T-Hg significantly increased wit age increased (Pliver>spleen. T-Hg content in females was higher than males (P<0.05). Acceptable monthly intake without carcinogenic effects due to mercury for women, men, juveniles and children was 270, 320, 125 and 59g per month. Consumption of pike above 35cm. length should be avoided

Role of plasma membrane lipid composition on cellular homeostasis: learning from cell line models expressing fatty acid desaturases

Experimental evidence has suggested that plasma membrane (PM)-associated signaling and hence cell metabolism and viability depend on lipid composition and organization. The aim of the present work is to develop a cell model to study the endogenous polyunsaturated fatty acids (PUFAs) effect on PM properties and analyze its influence on cholesterol (Chol) homeostasis. We have previously shown that by using a cell line over-expressing stearoyl-CoA-desaturase, membrane composition and organization coordinate cellular pathways involved in Chol efflux and cell viability by different mechanisms. Now, we expanded our studies to a cell model over-expressing both Δ5 and Δ6 desaturases, which resulted in a permanently higher PUFA content in PM. Furthermore, this cell line showed increased PM fluidity, Chol storage, and mitochondrial activity. In addition, human apolipoprotein A-I-mediated Chol removal was less efficient in these cells than in the corresponding control. Taken together, our results suggested that the cell functionality is preserved by regulating PM organization and Chol exportation and homeostasis.Fil: Jaureguiberry, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Bioquímicas de la Plata; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Tricerri, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Bioquímicas de la Plata; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Sanchez, Susana A.. University Of California At Irvine. Laboratory of Fluorescence Dynamics; Estados UnidosFil: Finarelli, Gabriela Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Bioquímicas de la Plata; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Montanaro, Mauro Aldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Bioquímicas de la Plata; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Prieto, Eduardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Bioquímicas de la Plata; ArgentinaFil: Rimoldi, Omar Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Bioquímicas de la Plata; Argentina. Universidad Nacional de La Plata; Argentin

Outcomes of chronic total occlusion percutaneous coronary intervention from the RAIAN (RAjaie - Iran) registry

Objective: While most of the evidence in CTO interventions emerge from Western and Japanese studies, few data have been published up today from the Middle East. Objective of this study was to evaluate technical success rates and clinical outcomes of an Iranian population undergoing CTO PCI in a tertiary referral hospital. Moreover, we sought to evaluate the efficacy of our CTO teaching program. Methods: This is a retrospective single-center cohort study including 790 patients who underwent CTO PCI performed by operators with different volumes of CTOs PCI performed per year. According to PCI result, all patients have been divided into successful (n&nbsp;=&nbsp;555, 70.3&nbsp;%) and unsuccessful (n&nbsp;=&nbsp;235, 29.7&nbsp;%) groups. Study endpoints were Major Adverse Cardiovascular Events and Health Status Improvement evaluated using the Seattle Angina Questionnaire at one year. Results: A global success rate of 70&nbsp;% for antegrade and 80&nbsp;% for retrograde approach was shown despite the lack of some CTO-dedicated devices. During the enrollment period, the success rate increased significantly among operators with a lower number of CTO procedures per year. One-year MACE rate was similar in both successful and unsuccessful groups (13.5&nbsp;% in successful and 10.6&nbsp;% in unsuccessful group, p&nbsp;=&nbsp;0.173). One year patients' health status improved significantly only in successful group. Conclusions: No significant differences of in-hospital and one-year MACE were found between the successful and unsuccessful groups. Angina symptoms and quality of life significantly improved after successful CTO PCI. The RAIAN registry confirmed the importance of operator expertise for CTO PCI success

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration to induce an inflammatory background have successfully reproduced idiosyncratic hepatotoxicity signatures for certain drugs. However, the low-throughput nature of these models renders them problematic for employment as preclinical screening assays. Here, we present an analogous, but high-throughput, in vitro approach in which drugs are administered to a variety of cell types (primary human and rat hepatocytes and the human HepG2 cell line) across a landscape of inflammatory contexts containing LPS and cytokines TNF, IFNγ, IL-1α, and IL-6. Using this assay, we observed drug–cytokine hepatotoxicity synergies for multiple idiosyncratic hepatotoxicants (ranitidine, trovafloxacin, nefazodone, nimesulide, clarithromycin, and telithromycin) but not for their corresponding non-toxic control compounds (famotidine, levofloxacin, buspirone, and aspirin). A larger compendium of drug–cytokine mix hepatotoxicity data demonstrated that hepatotoxicity synergies were largely potentiated by TNF, IL-1α, and LPS within the context of multi-cytokine mixes. Then, we screened 90 drugs for cytokine synergy in human hepatocytes and found that a significantly larger fraction of the idiosyncratic hepatotoxicants (19%) synergized with a single cytokine mix than did the non-hepatotoxic drugs (3%). Finally, we used an information theoretic approach to ascertain especially informative subsets of cytokine treatments for most highly effective construction of regression models for drug- and cytokine mix-induced hepatotoxicities across these cell systems. Our results suggest that this drug–cytokine co-treatment approach could provide a useful preclinical tool for investigating inflammation-associated idiosyncratic drug hepatotoxicity.Pfizer Inc.Institute for Collaborative BiotechnologiesMIT Center for Cell Decision ProcessesNational Institute of Mental Health (U.S.) (grant P50-GM68762)National Institute of Mental Health (U.S.) (grant T32-GM008334)Massachusetts Institute of Technology. Biotechnology Process Engineering CenterMassachusetts Institute of Technology. Center for Environmental Health SciencesNational Institute of Mental Health (U.S.) (grant U19ES011399)Whitaker Foundatio