Revisited the relationship between vitamin D level and receptors of BsmI-gene polymorphism with the pathogenetic mechanisms of placental dysfunction development

The role of the calcitriol / vitamin D receptor (VD) endocrine system and the pleiotropic effects of this system in the pathogenetic mechanisms of various diseases development, in particular complications of pregnancy, has attracted researches’ increasing attention in recent years. The aim of the work: to compare the VD-status and frequency of occurrence of polymorphism of the VDR gene (BsmI (A> G, rs1544410) in patients with a physiological course of the gestation process and in patients with placental dysfunction (PD). Materials and methods. 56 pregnant women with PD (the main group) and 40 patients with a physiological pregnancy (control group) were examined. VD status was determined by ELISA at level 25 (OH) D in serum, the frequency of BsmI polymorphism of the VDR gene (rs1544410) by polymerase chain reaction (PCR). Results. The average index of VD (31.40 ± 8.6) ng / ml in patients with PD is significantly lower than in patients with physiological pregnancy (43.54 ± 11.20) ng / ml, (p ≤ 0.05 ). In patients with PD, homozygous carrier for the A-allele was found in 12% of cases, in healthy pregnant women - in 16.7%, (р ≥ 0.05), for the G-allele - in 20% and 47.20%, (р ≤ 0.01) cases, respectively to groups. Heterozygous combination of A / G alleles was noted in 68% of patients with PD and in 36.10% of the control group patients. In pregnant women with BsmI polymorphism of calcitriol gene (genotype A / G) PD was 3.7 times more frequent (68% vs 36.10% : RR = 2.1, CI 1.0-6.6, OR = 3.7, CI 1.1-13.1). Conclusions. Vitamin D insufficiency or deficiency can be one of the reasons of PD formation. In carriers of BsmIgene’s polymorphism encoding VD receptor with genotype A / G, the course of pregnancy is complicated by placental dysfunction 3.7 times more often than in women without this polymorphism

Monitoring patient profiles from the pharmacy : an opportunity for the pharmacist to contribute to patient care

The literature clearly indicates that pharmacist monitoring of hospital patients by use of a patient profile is needed. The literature does not, however, describe a method of selecting the information to be included on the profile. Since monitoring needs vary from hospital to hospital, a method of identifying specific needs is necessary. Therefore, this study was undertaken in three parts to develop such a method. Part I was concerned with devising a list of the types of information which can be monitored by the pharmacist. This list included both patient information, such as age and weight, and therapeutic information, such as drug regimens and laboratory tests. Another list was then generated of all contributions a pharmacist can make to patient care. A contribution was defined as any action the pharmacist can take to insure safety of the patient's drug-related therapy and to provide for the optimal use of medications. It was then possible to identify which types of information lead to making specific contributions to patient care and which were non-productive. Part II consisted of designing the A-P-C (All-Possible-Contributions) profile. This profile contains all of the information found in part I to be useful, enabling the pharmacist to make all of the contributions possible to patient care. The third part was the application of the newly devised A-P-C profile to an actual hospital pharmacy practice. The contributions to patient care which were needed were identified on the basis of finding drug-drug interactions, adverse drug reactions, etc. occurring in the sampled patients' therapy. Once the needed contributions were identified by use of the A-P-C profile, the pharmacist was able to know which types of information he must monitor. Any extraneous information was then eliminated from the A-P-C profile, and a new profile drawn up for use thereafter. In part I, seventeen types of information were found to be useful for making the fifteen possible contributions to patient care. Application of the A-P-C profile to the actual hospital practice indicated that fourteen types of information should be monitored to make possible the twelve contributions shown to be needed. The results of the study indicate that the A-P-C profile can be used to identify the specific monitoring requirement of a given hospital pharmacy practice, which can lead to safer and more effective therapy

Applying MAPP Algorithm for Cooperative Path Finding in Urban Environments

The paper considers the problem of planning a set of non-conflict trajectories for the coalition of intelligent agents (mobile robots). Two divergent approaches, e.g. centralized and decentralized, are surveyed and analyzed. Decentralized planner - MAPP is described and applied to the task of finding trajectories for dozens UAVs performing nap-of-the-earth flight in urban environments. Results of the experimental studies provide an opportunity to claim that MAPP is a highly efficient planner for solving considered types of tasks

Vitamin D def ciency as a predictor of the implementation intrauterine infection

В статье представлены результаты исследования взаимосвязи дефицита витамина D с активностью и клиническими проявлениями воспалительного процесса при внутриутробном инфицировании.The article presents the results of studies on the relationship of vitamin D defciency with activity and clinical manifestations of inflammatory process in the intrauterine infection

The structure and characteristics of photochromic dithienylethenes

Abstract. The data on X-ray diffraction analysis for dihetarylethenes with perfluorocyclopentene (F), maleic anhydride (M) and cyclobutenedione (S) bridges between thienyl fragments were summarized and their photochromic properties were discussed. It was established that benzoxazole and benzothiazole substituents in position 5 of thienyl rings are coplanar to the plane of thiophene cycles. Thienyl fragments in A form of all dithienylethenes are considerably turned relative to the plane of bridging cycle. It means that there is no conjugation between π -electrons of aromatic heterocycles and double bond of the bridge. Flattening of molecule framework and the envelope conformation of thienyl cycles because of aromaticity loss are characteristic features of the form B structure with F-bridge. In all cases (excluding the compounds with alkylthio substituents in position 2 of thiophene cycle) the photochromic transition A −→ B is observed independently of different nature and structure of functional groups

Системный уровень фактора некроза опухоли–α (ФНО-α) и его динамика

Целью работы является исследование системного уровня ФНО-а и его динамики на фоне комплексного лечения (иммуномодулятора в сочетании с кальцийсодержащим препаратом) у беременных с остеопенией и верифицированным перинатальным инфицированием

Osteoporosis and pregnancy. Developmental mechanics of disorder

В огляді наведено сучасні погляди на регуляцію кальцієвого гомеостазу і можливі механізми формування остеопорозу під час вагітності. Особлива увага приділяється процесам регуляції ремоделювання кісткової тканини під впливом стероїдних гормонів, паратиреоїдного гормону, вітаміну D і кальцитоніну, а також простагландинів.This paper gives a modern view at osteoporosis and pregnancy and briefly discusses the relationship between pregnancy and bone mass, calcium homeostasis, steroid hormones, vitamin D, parathyroid hormone and local factors to help explaining the pathophysiology of this disorder

Exogenous spatial precuing reliably modulates object processing but not object substitution masking

Object substitution masking (OSM) is used in behavioral and imaging studies to investigate processes associated with the formation of a conscious percept. Reportedly, OSM occurs only when visual attention is diffusely spread over a search display or focused away from the target location. Indeed, the presumed role of spatial attention is central to theoretical accounts of OSM and of visual processing more generally (Di Lollo, Enns, & Rensink, Journal of Experimental Psychology: General 129:481–507, 2000). We report a series of five experiments in which valid spatial precuing is shown to enhance the ability of participants to accurately report a target but, in most cases, without affecting OSM. In only one experiment (Experiment 5) was a significant effect of precuing observed on masking. This is in contrast to the reliable effect shown across all five experiments in which precuing improved overall performance. The results are convergent with recent findings from Argyropoulos, Gellatly, and Pilling (Journal of Experimental Psychology: Human Perception and Performance 39:646–661, 2013), which show that OSM is independent of the number of distractor items in a display. Our results demonstrate that OSM can operate independently of focal attention. Previous claims of the strong interrelationship between OSM and spatial attention are likely to have arisen from ceiling or floor artifacts that restricted measurable performance