Associations of height, leg length, and lung function with cardiovascular risk factors in the Midspan Family Study

<b>Background</b>: Taller people and those with better lung function are at reduced risk of coronary heart disease (CHD). Biological mechanisms for these associations are not well understood, but both measures may be markers for early life exposures. Some studies have shown that leg length, an indicator of pre-pubertal nutritional status, is the component of height most strongly associated with CHD risk. Other studies show that height-CHD associations are greatly attenuated when lung function is controlled for. This study examines (1) the association of height and the components of height (leg length and trunk length) with CHD risk factors and (2) the relative strength of the association of height and forced expiratory volume in one second (FEV1) with risk factors for CHD. <b>Subjects and methods</b>: Cross sectional analysis of data collected at detailed cardiovascular screening examinations of 1040 men and 1298 women aged 30–59 whose parents were screened in 1972–76. Subjects come from 1477 families and are members of the Midspan Family Study. <b>Setting</b>: The towns of Renfrew and Paisley in the West of Scotland. <b>Results</b>: Taller subjects and those with better lung function had more favourable cardiovascular risk factor profiles, associations were strongest in relation to FEV1. Higher FEV1 was associated with lower blood pressure, cholesterol, glucose, fibrinogen, white blood cell count, and body mass index. Similar, but generally weaker, associations were seen with height. These associations were not attenuated in models controlling for parental height. Longer leg length, but not trunk length, was associated with lower systolic and diastolic blood pressure. Longer leg length was also associated with more favourable levels of cholesterol and body mass index than trunk length. <b>Conclusions</b>:These findings provide indirect evidence that measures of lung development and pre-pubertal growth act as biomarkers for childhood exposures that may modify an individual's risk of developing CHD. Genetic influences do not seem to underlie height-CHD associations

Conditional GIS surfaces and their potential for archaeological predictive modelling

Conditional GIS surfaces are well known in archaeological applications. Perhaps the most familiar of these are visibility analyses and friction layers (the basis of cost distance evaluations). Archaeological studies however tend to limit the use of such surfaces to purely environmental variables with little explanatory or analytical power. Friction, for example, is usually constructed entirely from a generated slope surface, occasionally with the addition of some physical barriers (such as waterways or perhaps vegetation differences). There are as well, a multitude of potential “conditions” to place upon spatial parameters which include strongly cultural ideas about knowledge, perception, familiarity, territoriality, risk, and other kinds of cognitive behaviours. Here we explore the kinds of “conditions” which could provide a great deal of explanatory or analytical understanding to our GIS archaeological applications, to categorize them into a meaningful framework, and to provide examples from a recent predictive model of how such surfaces can be applied

Predictive modeling of cultural resources in the Theban necropolis, Luxor, Egypt

The Egyptian Government created the Egyptian Antiquities Information System (EAIS) and a Comprehensive Development Plan to help protect cultural resources in the Theban Necropolis, Luxor, Egypt. By creating a cognitive predictive model and assessing its utility in locating tombs, researchers could be aided in the understanding of why these locations were preferred by the ancient Egyptians. The cognitive evaluations used include tomb location relative to geology, slope, elevation, fractures, and religious/burial practices. A set of sensitivity surfaces was created using Geographical Information System (GIS) / statistical analysis of measured and derived environmental and cultural attributes. Analysis of fifteen sensitivity surfaces produced two viable models which could be combined with the EAIS database to help show which areas should be avoided or studied further. The most important information generated from this research is the fact that there is a lack of focus in the archaeological world concerning why tomb locations were chosen

An Investigation of the Relationship Between Psychological Strengths and the Perception of Bullying in Early Adolescents in Schools

This study explored the association between psychological strengths and perceptions of being a victim of a bullying relationship in the school environment. Using self-report questionnaires with grades 7 and 8 students, the role of psychological strengths as potential protective factors against various forms of bullying were examined including the patterns of strengths associated with the bullying experience. The results showed no significant association between global indices of strengths and perceptions of victimization. However, significant relationships did emerge between specific strengths and victimization. Strengths in school functioning among boys but not girls and strengths in personality functioning for both sexes were associated with lower perceived victimization. In contrast, strengths in spiritual and cultural identification were associated with perceptions of increased victimization. The implications of these results for anti-bullying strategies are discussed.Cette étude a porté sur l'association entre les forces psychologiques et les perceptions d'être victime d'intimidation à l'école. En nous appuyant sur des questionnaires d'auto-évaluation auprès d'élèves en 7e et 8e année, nous avons examiné le rôle des forces psychologiques comme facteurs potentiels de protection contre diverses formes d'intimidation. L'étude a également porté sur les modèles de forces associés à l'expérience de l'intimidation. Les résultats n'ont indiqué aucune association entre les indices globaux de forces et les perceptions de l'intimidation. Toutefois, des relations significatives sont ressorties entre des forces spécifiques et l'intimidation. Des forces relatives à l'école chez les garçons mais pas les filles, et des forces relatives à la personnalité chez les garçons et les filles, étaient associées à une perception amoindrie de la victimisation. Par contre, des forces relatives à l'identification spirituelle et culturelle étaient associées à des perceptions accrues de victimisation. Nous discutons des répercussions de ces résultats sur les stratégies contre l'intimidation

Advancing understanding on industrial relations in multinational companies: key research challenges and the INTREPID contribution

peer-reviewedThis paper has three principal aims. It firstly provides some theoretical background on the key current research issues and challenges in regard to industrial relations in multinational companies. It then presents a concise review of scholarship to date on industrial relations in multinational companies using INTREPID (Investigation of Transnationals Employment Practices: an International Database) data. Finally, the paper identifies some of the main industrial relations issues that remain to be addressed, in effect charting a form of research agenda for future work using the INTREPID data, with particular focus on the potential contribution from ‘late joiners’ to the INTREPID project.ACCEPTEDpeer-reviewe

Variations in cognitive abilities across the life course: Cross-sectional evidence from Understanding Society : The UK Household Longitudinal Study

Background: Populations worldwide are aging. Cognitive decline is an important precursor of dementia, illness and death and, even within the normal range, is associated with poorer performance on everyday tasks. However, the impact of age on cognitive function does not always receive the attention it deserves. Methods: We have explored cross-sectional associations of age with five cognitive tests (word recall, verbal fluency, subtraction, number sequence, and numerical problem solving) in a large representative sample of over 40,000 men and women aged 16 to 100 living in the UK. Results: Women performed better on word recall tests and men had higher scores for subtraction, number sequence and numerical problem solving. However, age-cognition associations were generally similar in both genders. Mean word recall and number sequence scores decreased from early adulthood with steeper declines from the mid-60s onwards Verbal fluency, subtraction and numerical problem solving scores remained stable or increased from early to mid-adulthood, followed by approximately linear declines from around age 60. Performance on all tests was progressively lower in respondents with increasingly worse self-rated health and memory. Age-related declines in word recall, verbal fluency and number sequence started earlier in those with the worst self-rated health. There was no compelling evidence for age dedifferentiation (that the general factor of cognitive ability changes in strength with age). Conclusions: We have confirmed previously observed patterns of cognitive aging using a large representative population sample

Dynamic consent: a possible solution to improve patient confidence and trust in how electronic patient records are used in medical research

With one million people treated every 36 hours, routinely collected UK National Health Service (NHS) health data has huge potential for medical research. Advances in data acquisition from electronic patient records (EPRs) means such data are increasingly digital and can be anonymised for research purposes. NHS England’s care.data initiative recently sought to increase the amount and availability of such data. However, controversy and uncertainty following the care.data public awareness campaign led to a delay in rollout, indicating that the success of EPR data for medical research may be threatened by a loss of patient and public trust. The sharing of sensitive health care data can only be done through maintaining such trust in a constantly evolving ethicolegal and political landscape. We propose that a dynamic consent model, whereby patients can electronically control consent through time and receive information about the uses of their data, provides a transparent, flexible, and user-friendly means to maintain public trust. This could leverage the huge potential of the EPR for medical research and, ultimately, patient and societal benefit

Dynamic consent: a possible solution to improve patient confidence and trust in how electronic patient records are used in medical research

With one million people treated every 36 hours, routinely collected UK National Health Service (NHS) health data has huge potential for medical research. Advances in data acquisition from electronic patient records (EPRs) means such data are increasingly digital and can be anonymised for research purposes. NHS England’s care.data initiative recently sought to increase the amount and availability of such data. However, controversy and uncertainty following the care.data public awareness campaign led to a delay in rollout, indicating that the success of EPR data for medical research may be threatened by a loss of patient and public trust. The sharing of sensitive health care data can only be done through maintaining such trust in a constantly evolving ethicolegal and political landscape. We propose that a dynamic consent model, whereby patients can electronically control consent through time and receive information about the uses of their data, provides a transparent, flexible, and user-friendly means to maintain public trust. This could leverage the huge potential of the EPR for medical research and, ultimately, patient and societal benefit

Psychosocial characteristics as potential predictors of suicide in adults: an overview of the evidence with new results from prospective cohort studies.

In this narrative overview of the evidence linking psychosocial factors with future suicide risk, we collected results from published reports of prospective studies with verified suicide events (mortality or, less commonly, hospitalisation) alongside analyses of new data. There is abundant evidence indicating that low socioeconomic position, irrespective of the economic status of the country in question, is associated with an increased risk of suicide, including the suggestion that the recent global economic recession has been responsible for an increase in suicide deaths and, by proxy, attempts. Social isolation, low scores on tests of intelligence, serious mental illness (both particularly strongly), chronic psychological distress, and lower physical stature (a marker of childhood exposures) were also consistently related to elevated suicide rates. Although there is some circumstantial evidence for psychosocial stress, personality disposition, and early-life characteristics such as bullying being risk indices for suicide, the general paucity of studies means it is not currently possible to draw clear conclusions about their role. Most suicide intervention strategies have traditionally not explored the modification of psychosocial factors, partly because evidence linking psychosocial factors with suicide risk is, as shown herein, largely in its infancy, or, where is does exist, for instance for intelligence and personality disposition, the characteristics in question do not appear to be easily malleable