Evaluating global e-government sites: A view using web diagnostics tools

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2004 The AuthorsSeveral governments across the world have embraced the digital revolution and continue to take advantage of the information and communication facilities offered by the Internet to offer public services. Conversely, citizens’ awareness and expectations of Internet based online-public-services have also increased in recent times. Although the numbers of the different national e-Government web portals have rapidly increased in the last three years, the success of these portals will largely depend on their accessibility, quality and privacy. This paper reports the results of an evaluative study of a cross-section of e-Government portals from these three perspectives, using a common set of performance metrics and Web diagnostic engines. Results show that not only are there wide variations in the spectrum of information and services provided by these portals, but that significant work still needs to be undertaken in order to make the portals examples of ‘best practice’ e-Government services

Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research

Non-invasive respiratory support (NIRS) has increasingly been used in the management of COVID-19-associated acute respiratory failure, but questions remain about the utility, safety, and outcome benefit of NIRS strategies. We identified two randomised controlled trials and 83 observational studies, compromising 13 931 patients, that examined the effects of NIRS modalities-high-flow nasal oxygen, continuous positive airway pressure, and bilevel positive airway pressure-on patients with COVID-19. Of 5120 patients who were candidates for full treatment escalation, 1880 (37%) progressed to invasive mechanical ventilation and 3658 of 4669 (78%) survived to study end. Survival was 30% among the 1050 patients for whom NIRS was the stated ceiling of treatment. The two randomised controlled trials indicate superiority of non-invasive ventilation over high-flow nasal oxygen in reducing the need for intubation. Reported complication rates were low. Overall, the studies indicate that NIRS in patients with COVID-19 is safe, improves resource utilisation, and might be associated with better outcomes. To guide clinical decision making, prospective, randomised studies are needed to address timing of intervention, optimal use of NIRS modalities-alone or in combination-and validation of tools such as oxygenation indices, response to a trial of NIRS, and inflammatory markers as predictors of treatment success

High performance MIIM diode based on cobalt oxide/titanium oxide

Metal-insulator-metal (MIM) or metal-insulator-insulator- metal (MIIM) diodes are incorporated with micron-scale antennas in optical rectennas for converting infrared radiation into electrical power. They are suited for such an application due to their high frequency rectification properties1 and relatively low cost, as compared to diodes formed on single crystal substrates. Their rectification characteristics, as determined from direct current (DC) current-voltage [I(V)] measurements, are usually inferior to those of semiconductor diodes

Factors affecting e-Government implementation and adoption in the State of Qatar

Electronic government (e-government) has established as an effective mechanism for increasing government productivity and efficiency and a key enabler of citizen-centric services. However, e-government implementation is surrounded by organisational, technological, political and social issues, which have to be considered and treated carefully in order to facilitate this change. Conversely, from an adoption perspective, e-government services are yet to be universally accepted as a medium for accessing online public services since its inception more than a decade ago. In terms of prior research into understanding the implementation challenges and adoption factors, most existing literature focus into either the implementation context or adoption context separately and no research studies were found that take a holistic viewpoint of both implementation and adoption. Furthermore, only a few researchers have explored and reflected on the important factors that can impact e-government implementation using well founded theoretical models or frameworks. Besides, there is no universal model for e-government implementation and adoption that is applicable for all countries to ensure success, especially for developing and Gulf Cooperation Countries (GCC). Therefore, this thesis attempts to explore and investigate the key challenges that influence e-government implementation and the factors influencing citizen adoption in the state of Qatar. By simultaneously analysing and aligning the implementation issues of e-government with the adoption aspects, this study aimed to develop a better understanding of the gaps that exists between implementation and adoption. Through combining the implementation and adoption aspects of e-government, this thesis proposes a unified conceptual model which could be used as a frame of reference by government institutions that seek to implement and diffuse e-government systems in Qatar. To do so, the research draws from two well established theoretical models, Institutional Theory (for understanding implementation) and the Unified Theory of Acceptance and Use of Technology (UTAUT) model (for understanding adoption). The research adopted a multi-method approach [combining qualitative (interviews) and quantitative (survey) methods] to explore practices and experiences of implementing and adopting e-government systems in the State of Qatar.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

pHLIP Peptide Interaction with a Membrane Monitored by SAXS

The pH (Low) Insertion Peptides (pHLIP® peptides) find application in studies of membrane-associated folding, since spontaneous insertion of these peptides is conveniently triggered by varying pH. Here we employed small angle X-ray scattering (SAXS) to investigate WT pHLIP® peptide oligomeric state in solution at high concentrations and monitor changes in liposome structure upon peptide insertion into the bilayer. We established that even at high concentrations (up to 300 μM) WT pHLIP® peptide at pH 8.0 does not form oligomers higher than tetramers (which exhibit concentration-dependent transfer to monomeric state as it was shown previously). This finding has significance for medical applications, when high concentration of the peptide is injected into blood and diluted in blood circulation. The interaction of WT pHLIP® peptide with liposomes does not alter the unilamellar vesicle structure upon peptide adsorption by lipid bilayer at high pH or upon insertion across the bilayer at low pH. At the same time, SAXS data clearly reflect the insertion of the peptide into the membrane at low pH, which opens the possibility to investigate kinetic process of a polypeptide insertion and exit from the membrane in real time by time-resolved SAXS

Modulation of the pHLIP Transmembrane Helix Insertion Pathway

The membrane-associated folding/unfolding of pH (low) insertion peptide (pHLIP) provides an opportunity to study how sequence variations influence the kinetics and pathway of peptide insertion into bilayers. Here, we present the results of steady-state and kinetics investigations of several pHLIP variants with different numbers of charged residues, with attached polar cargoes at the peptide\u27s membrane-inserting end, and with three single-Trp variants placed at the beginning, middle, and end of the transmembrane helix. Each pHLIP variant exhibits a pH-dependent interaction with a lipid bilayer. Although the number of protonatable residues at the inserting end does not affect the ultimate formation of helical structure across a membrane, it correlates with the time for peptide insertion, the number of intermediate states on the folding pathway, and the rates of unfolding and exit. The presence of polar cargoes at the peptide\u27s inserting end leads to the appearance of intermediate states on the insertion pathway. Cargo polarity correlates with a decrease of the insertion rate. We conclude that the existence of intermediate states on the folding and unfolding pathways is not mandatory and, in the simple case of a polypeptide with a noncharged and nonpolar inserting end, the folding and unfolding appears as an all-or-none transition. We propose a model for membrane-associated insertion/folding and exit/unfolding and discuss the importance of these observations for the design of new delivery agents for direct translocation of polar therapeutic and diagnostic cargo molecules across cellular membranes

Can we bridge the gap? Knowledge and practices related to Diabetes Mellitus among general practitioners in a developing country: A cross sectional study

<p>Abstract</p> <p>Background</p> <p>Diabetes mellitus is becoming a serious public health problem in Sri Lanka and many other developing countries in the region. It is well known that effective management of diabetes reduces the incidence and progression of many diabetes related complications, thus it is important that General Practitioners (GPs) have sound knowledge and positive attitudes towards all aspects of its management. This study aims to assess knowledge, awareness and practices relating to management of Diabetes Mellitus among Sri Lankan GPs.</p> <p>Methods</p> <p>A cross-sectional study was conducted among all 246 GPs registered with the Ceylon College of General Practitioners using a pre-validated self-administered questionnaire.</p> <p>Results</p> <p>205 responded to the questionnaire(response rate 83.3%). Their mean duration of practice was 28.7 ± 11.2 years. On average, each GP had 27 ± 25 diabetic-patient consultations per-week. 96% managed diabetic patients and 24% invariably sought specialist opinion. 99.2% used blood glucose to diagnose diabetes but correct diagnostic cut-off values were known by only 48.8%. Appropriate use of HbA1c and urine microalbumin was known by 15.2% and 39.2% respectively. 84% used HbA1c to monitor glyceamic control, while 90.4% relied on fasting blood glucose to monitor glyceamic control. Knowledge on target control levels was poor.</p> <p>Nearly 90% correctly selected the oral hypoglyceamic treatment for obese as well as thin type 2 diabetic patients. Knowledge on the management of diabetes in pregnancy was poor. Only 23.2% knew the correct threshold for starting lipid-lowering therapy. The concept of strict glycaemic control in preference to symptom control was appreciated only by 68%. The skills for comprehensive care in subjects with multiple risk factors were unsatisfactory.</p> <p>Conclusions</p> <p>The study was done among experienced members of the only professional college dedicated to the specialty. However, we found that there is room for improvement in their knowledge and practices related to diabetes. We recommend continuing medical education and training programs to update GP's knowledge in order to improve health outcomes in this group of patients.</p

E-government adoption: A cultural comparison

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer Science + Business Media, LLC 2008.E-government diffusion is an international phenomenon. This study compares e-government adoption in the U.K. to adoption in the U.S. In particular, this study seeks to determine if the same factors are salient in both countries. Several studies have explored citizen acceptance of e-government services in the U.S. However, few studies have explored this phenomenon in the U.K. To identify the similarities and differences between the U.K. and the U.S. a survey is conducted in the U.K. and the findings are compared to the literature that investigates diffusion in the U.S. This study proposes a model of e-government adoption in the U.K. based on salient factors in the U.S. A survey is administered to 260 citizens in London to assess the importance of relative advantage, trust and the digital divide on intention to use e-government. The results of binary logistic regression indicate that there are cultural differences in e-government adoption in the U.K. and the U.S. The results indicate that of the prevailing adoption constructs, relative advantage and trust are pertinent in both the U.S. and the U.K., while ICT adoption barriers such as access and skill may vary by culture. Implications for research and practice are discussed