46 research outputs found
The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation.
MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains.
Cellular immunity to antigens associated with papovavirus sv40- -transformed cells. Abstr.
Requirement of thymus-derived theta-positive lymphocytes for rejection of dna virus (sv40) tumors in mice.
RAT LIVER GRAFT REJECTION AND TOLERANCE INDUCTION BY T AND NK CELLS FOLLOW THE IMMUNOGENETIC RULES OF BONE MARROW TRANSPLANTATION (BMT)
Glycosylphosphatidylinositol-anchored H-2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes.
Glycosylphosphatidylinositol-anchored (GPI)-Db molecules are defective in mediating cytotoxic T lymphocytes (CTL) lysis of transfected lymphoma cells, compared to their transmembrane (TM) counterpart. This defect is manifest when antigenic peptide must be processed and presented through the endogenous pathway. These same transfectants can be lysed by allospecific CTL, or by antigen-specific Db-restricted CTL when pulsed with appropriate exogenous synthetic peptide, demonstrating that they can bind and present peptide for CTL-mediated lympholysis. The defect apparently results from differences between GPI-Db and TM-Db assembly and transport, or from differences in membrane topology that affect CD8+ CTL recognition of major histocompatibility complex/peptide complex