13 research outputs found
A facile synthesis of N-Z/Boc-protected 1,3,4-oxadiazole-based peptidomimetics employing peptidyl thiosemicarbazides
Full text linkExploiting bacterial DNA gyrase as a drug target: current state and perspectives
Get PDFDNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials. The fluoroquinolones are examples of very successful gyrase-targeted drugs, but the rise in bacterial resistance to these agents means that we not only need to seek new compounds, but also new modes of inhibition of this enzyme. We review known gyrase-specific drugs and toxins and assess the prospects for developing new antibacterials targeted to this enzyme
Some aspects of the rhetorical structure of specialized written discourse in English, Bulgarian and Russian
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Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor
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Post-Translational Heterocyclic Backbone Modifications in the 43-Peptide Antibiotic Microcin B17. Structure Elucidation and NMR Study of a 13C,18N-Labelled Gyrase Inhibitor
No full textEfficacious and Orally Bioavailable Thrombin Inhibitors Based on a 2,5-Thienylamidine at the P1 Position: Discovery of N
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