Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase.

The paracaspase MALT1 is an Arg-specific protease that cleaves multiple substrates to promote lymphocyte proliferation and survival. The catalytic activity of MALT1 is normally tightly regulated by antigen receptor triggering, which promotes MALT1 activation by its inducible monoubiquitination-dependent dimerization. Constitutive MALT1 activity is a hallmark of specific subsets of B-cell lymphomas, which are characterized by chromosomal translocations or point mutations that activate MALT1 or its upstream regulators. Recent findings suggest that such lymphomas may be sensitive to treatment with MALT1 inhibitors. Here we review recent progress in the understanding of MALT1 function and regulation, and the development of small molecule MALT1 inhibitors for therapeutic applications

Feature Selection and Generalisation for Retrieval of Textual Cases

Textual CBR systems solve problems by reusing experiences that are in textual form. Knowledge-rich comparison of textual cases remains an important challenge for these systems. However mapping text data into a structured case representation requires a significant knowledge engineering effort. In this paper we look at automated acquisition of the case indexing vocabulary as a two step process involving feature selection followed by feature generalisation. Boosted decision stumps are employed as a means to select features that are predictive and relatively orthogonal. Association rule induction is employed to capture feature co-occurrence patterns. Generalised features are constructed by applying these rules. Essentially, rules preserve implicit semantic relationships between features and applying them has the desired effect of bringing together cases that would have otherwise been overlooked during case retrieval. Experiments with four textual data sets show significant improvement in retrieval accuracy whenever gener¬alised features are used. The results further suggest that boosted decision stumps with generalised features to be a promising combination

Deformed Gaussian Orthogonal Ensemble Analysis of the Interacting Boson Model

A Deformed Gaussian Orthogonal Ensemble (DGOE) which interpolates between the Gaussian Orthogonal Ensemble and a Poissonian Ensemble is constructed. This new ensemble is then applied to the analysis of the chaotic properties of the low lying collective states of nuclei described by the Interacting Boson Model (IBM). This model undergoes a transition order-chaos-order from the $SU(3)$ limit to the $O(6)$ limit. Our analysis shows that the quantum fluctuations of the IBM Hamiltonian, both of the spectrum and the eigenvectors, follow the expected behaviour predicted by the DGOE when one goes from one limit to the other.Comment: 10 pages, 4 figures (avaiable upon request), IFUSP/P-1086 Replaced version: in the previous version the name of one of the authors was omitte

Local Spectral Density for a Periodically Driven System of Coupled Quantum States with Strong Imperfection in Unperturbed Energies

A random matrix theory approach is applied in order to analyze the localization properties of local spectral density for a generic system of coupled quantum states with strong static imperfection in the unperturbed energy levels. The system is excited by an external periodic field, the temporal profile of which is close to monochromatic one. The shape of local spectral density is shown to be well described by the contour obtained from a relevant model of periodically driven two-states system with irreversible losses to an external thermal bath. The shape width and the inverse participation ratio are determined as functions both of the Rabi frequency and of parameters specifying the localization effect for our system in the absence of external field.Comment: 6 pages, 5 figures, submitted to Optics and Spectroscop

(1+1)-Dimensional Yang-Mills Theory Coupled to Adjoint Fermions on the Light Front

We consider SU(2) Yang-Mills theory in 1+1 dimensions coupled to massless adjoint fermions. With all fields in the adjoint representation the gauge group is actually SU(2)/Z_2, which possesses nontrivial topology. In particular, there are two distinct topological sectors and the physical vacuum state has a structure analogous to a \theta vacuum. We show how this feature is realized in light-front quantization, with periodicity conditions used to regulate the infrared and treating the gauge field zero mode as a dynamical quantity. We find expressions for the degenerate vacuum states and construct the analog of the \theta vacuum. We then calculate the bilinear condensate in the model. We argue that the condensate does not affect the spectrum of the theory, although it is related to the string tension that characterizes the potential between fundamental test charges when the dynamical fermions are given a mass. We also argue that this result is fundamentally different from calculations that use periodicity conditions in x^1 as an infrared regulator.Comment: 20 pages, Revte

Quantum Mechanics of the Vacuum State in Two-Dimensional QCD with Adjoint Fermions

A study of two-dimensional QCD on a spatial circle with Majorana fermions in the adjoint representation of the gauge groups SU(2) and SU(3) has been performed. The main emphasis is put on the symmetry properties related to the homotopically non-trivial gauge transformations and the discrete axial symmetry of this model. Within a gauge fixed canonical framework, the delicate interplay of topology on the one hand and Jacobians and boundary conditions arising in the course of resolving Gauss's law on the other hand is exhibited. As a result, a consistent description of the residual $Z_N$ gauge symmetry (for SU(N)) and the ``axial anomaly" emerges. For illustrative purposes, the vacuum of the model is determined analytically in the limit of a small circle. There, the Born-Oppenheimer approximation is justified and reduces the vacuum problem to simple quantum mechanics. The issue of fermion condensates is addressed and residual discrepancies with other approaches are pointed out.Comment: 44 pages; for hardcopies of figures, contact [email protected]

Correlations and pair emission in the escape dynamics of ions from one-dimensional traps

We explore the non-equilibrium escape dynamics of long-range interacting ions in one-dimensional traps. The phase space of the few ion setup and its impact on the escape properties are studied. As a main result we show that an instantaneous reduction of the trap's potential depth leads to the synchronized emission of a sequence of ion pairs if the initial configurations are close to the crystalline ionic configuration. The corresponding time-intervals of the consecutive pair emission as well as the number of emitted pairs can be tuned by changing the final trap depth. Correlations between the escape times and kinetic energies of the ions are observed and analyzed.Comment: 17 pages, 9 figure

QCD near the Light Cone

Starting from the QCD Lagrangian, we present the QCD Hamiltonian for near light cone coordinates. We study the dynamics of the gluonic zero modes of this Hamiltonian. The strong coupling solutions serve as a basis for the complete problem. We discuss the importance of zero modes for the confinement mechanism.Comment: 32 pages, ReVTeX, 2 Encapsulated PostScript figure