Opinion On Drug Information Services Provided In A Multi- Specialty Teaching Hospital

Objective: To evaluate the various drug information queriesreceived, and to access the drug information services providedby the pharmacy practice department.Method: Drug information queries received during wardrounds, direct communication, telephone or internet etc. weredocumented in the drug information request anddocumentation forms prepared by the department over theperiod of January 2010 to June 2010. Various parameters likestatus of enquirer, their specialty, mode of receipt of query,purpose of query, type of query etc. were consider forevaluation.Results: Out of 208 queries received, major 56 (26.9%) frommale medical ward. Maximum [82 (39.4 %)] queries were fromthe physicians. 73 (35.0 %) of the queries were about therecent advances and the updating of the information, It wasfound that mostly the mode of request was during wardrounds 85 (40.9%). Most of the queries [126 (60.6%)] wereanswered by written or printout format. Majority of thequeries [195 (93.8 %)] were answered directly to theenquirers through direct access. Most of the queries wereanswered through books in the department [86 (41.3 %)].Conclusion: Results of the external auditing revealed thatrequestors were generally satisfied with the service provided.The drug information services provided by clinical pharmacistsat the hospital were found to be useful and beneficial to thehealthcare professionals and patients

IN-VITRO OBSERVATION OF REPAGLINIDE ENGINEERED POLYMERIC NANOPARTICLES

Nanoparticles (NP) are tiny materials that have specific physicochemical properties different to bulk materials of same composition and such properties make them very attractive for commercial and medical development. The aim of this work was to produce and characterize Repaglinide (Rg) engineered Ethyl Cellulose NP by the solvent evaporation model, in an attempt to obtain a novel delivery system adequate for the treatment of diabetes. Batches were prepared with different ratios of drug and polymer in order to evaluate the influence of drug on NP properties. The absence of any chemical interaction between drug and polymer was confirmed by Fourier Transform Infra Red spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Thermo Gravimetric Analysis (TGA) techniques. X-Ray Diffraction pattern of formulation confirmed the superimposition of polymer and drug with lower intensity. The average diameter of NP determined by Photon Correlation Spectroscopy (PCS) was about 100nm. NP showed 86.4% Encapsulation Efficiency (EE) and 9.61% drug loading. Finally, the in-vitro release profile observed for these NP was characterized by a delayed release phase. Questions about the potential haemolytic activity of formulated nanoparticles i.e., cytotoxicity was proved by our results. Interestingly, these results suggest that nano encapsulation of the drug in biodegradable, biocompatible polymer will improve its pharmacological significance

Evaluation of wound healing potential and antimicrobial activity of ethanolic extract of Evolvulus alsinoides

International audienc

Design and In Vitro/In Vivo Evaluation of Ultra-Thin Mucoadhesive Buccal Film Containing Fluticasone Propionate

Fluticasone propionate is a synthetic corticosteroid drug distinguished by its potent anti-inflammatory action with low systemic side effects in comparison to other corticosteroids making it a potential drug for local buccal delivery. The aim of the present study was to design mucoadhesive buccal film containing fluticasone that is aesthetically acceptable and could maintain local drug release for a sustained period to manage the sign and symptoms of severe erosive mouth lesions. Solvent casting technique was used in film preparation. Different polymeric blends were used either alone or in combination with mucoadhesive polymers, sodium carboxymethyl cellulose (SCMC), or Carbopol 971P at different concentrations. The physicochemical properties, in vitro mucoadhesion time as well as the drug release properties for all prepared formulations were determined. Selected formulations with adequate properties were further examined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) and subjected to in vivo evaluation. Films containing hydroxypropyl methylcellulose (HPMC)/ethyl cellulose (EC) showed acceptable physicochemical properties, homogenous drug distribution, convenient mucoadhesion time, moderate swelling as well as sustained drug release up to 12 h. The biological performance of these formulations was assessed on healthy human volunteers and compared with a prepared mouthwash which showed enhanced pharmacokinetic parameters for the selected films in comparison to the mouthwash. The results revealed that the optimized formulation containing HPMC/EC and 10% SCMC could successfully achieve sustained drug release for 10 h which is considered promising for local treatment of severe mouth lesions