36 research outputs found
Effects of confinement on pattern formation in two dimensional systems with competing interactions
Template-assisted pattern formation in monolayers of particles with competing short-range attraction and long-range repulsion interactions (SALR) is studied by Monte Carlo simulations in a simple generic model [N. G. Almarza et al., J. Chem. Phys., 2014, 140, 164708]. We focus on densities corresponding to formation of parallel stripes of particles and on monolayers laterally confined between straight parallel walls. We analyze both the morphology of the developed structures and the thermodynamic functions for broad ranges of temperature T and the separation L between the walls. At low temperature stripes parallel to the boundaries appear, with some corrugation when the distance between the walls does not match the bulk periodicity of the striped structure. The stripes integrity, however, is rarely broken for any L. This structural order is lost at T = T(L) depending on L according to a Kelvin-like equation. Above the Kelvin temperature T(L) many topological defects such as breaking or branching of the stripes appear, but a certain anisotropy in the orientation of the stripes persists. Finally, at high temperature and away from the walls, the system behaves as an isotropic fluid of elongated clusters of various lengths and with various numbers of branches. For L optimal for the stripe pattern the heat capacity as a function of temperature takes the maximum at T = T(L).Peer Reviewe
Numerical study of the critical behavior of the Ashkin-Teller model at a line defect
We consider the Ashkin-Teller model on the square lattice, which is
represented by two Ising models ( and ) having a four-spin
coupling of strength, , between them. We introduce an asymmetric
defect line in the system along which the couplings in the Ising model
are modified. In the Hamiltonian version of the model we study the scaling
behavior of the critical magnetization at the defect, both for and for
spins by density matrix renormalization. For we observe
identical scaling for and spins, whereas for one
model becomes locally ordered and the other locally disordered. This is
different of the critical behavior of the uncoupled model () and is
in contradiction with the results of recent field-theoretical calculations.Comment: 6 pages, 4 figure
Simulated ecology-driven sympatric speciation
We introduce a multi-locus genetically acquired phenotype, submitted to
mutations and with selective value, in an age-structured model for biological
aging. This phenotype describes a single-trait effect of the environment on an
individual, and we study the resulting distribution of this trait among the
population. In particular, our simulations show that the appearance of a double
phenotypic attractor in the ecology induces the emergence of a stable
polymorphism, as observed in the Galapagos finches. In the presence of this
polymorphism, the simulations generate short-term speciation, when mating
preferences are also allowed to suffer mutations and acquire selective value.Comment: 11 pages, 5 figures, 1 table, uses package RevTe
Phase Transitions and Oscillations in a Lattice Prey-Predator Model
A coarse grained description of a two-dimensional prey-predator system is
given in terms of a 3-state lattice model containing two control parameters:
the spreading rates of preys and predators. The properties of the model are
investigated by dynamical mean-field approximations and extensive numerical
simulations. It is shown that the stationary state phase diagram is divided
into two phases: a pure prey phase and a coexistence phase of preys and
predators in which temporal and spatial oscillations can be present. The
different type of phase transitions occuring at the boundary of the prey
absorbing phase, as well as the crossover phenomena occuring between the
oscillatory and non-oscillatory domains of the coexistence phase are studied.
The importance of finite size effects are discussed and scaling relations
between different quantities are established. Finally, physical arguments,
based on the spatial structure of the model, are given to explain the
underlying mechanism leading to oscillations.Comment: 11 pages, 13 figure
Topology and Computational Performance of Attractor Neural Networks
To explore the relation between network structure and function, we studied
the computational performance of Hopfield-type attractor neural nets with
regular lattice, random, small-world and scale-free topologies. The random net
is the most efficient for storage and retrieval of patterns by the entire
network. However, in the scale-free case retrieval errors are not distributed
uniformly: the portion of a pattern encoded by the subset of highly connected
nodes is more robust and efficiently recognized than the rest of the pattern.
The scale-free network thus achieves a very strong partial recognition.
Implications for brain function and social dynamics are suggestive.Comment: 2 figures included. Submitted to Phys. Rev. Letter
On metastable configurations of small-world networks
We calculate the number of metastable configurations of Ising small-world
networks which are constructed upon superimposing sparse Poisson random graphs
onto a one-dimensional chain. Our solution is based on replicated
transfer-matrix techniques. We examine the denegeracy of the ground state and
we find a jump in the entropy of metastable configurations exactly at the
crossover between the small-world and the Poisson random graph structures. We
also examine the difference in entropy between metastable and all possible
configurations, for both ferromagnetic and bond-disordered long-range
couplings.Comment: 9 pages, 4 eps figure
Widespread seasonal gene expression reveals annual differences in human immunity and physiology.
Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease.The Gambian study providing data for analysis was supported by core funding MC-A760-5QX00 to the International Nutrition Group by the UK Medical Research Council (MRC) and the UK Department for the International Development (DFID) under the MRC/DFID Concordat agreement. This work was supported by the JDRF UK Centre for Diabetes-Genes, Autoimmunity and Prevention (D-GAP; 4-2007-1003), the JDRF (9-2011-253), the Wellcome Trust (WT061858/091157), the National Institute for Health Research Cambridge Biomedical Research Centre (CBRC) and the Medical Research Council (MRC) Cusrow Wadia Fund. The research leading to these results has received funding from the European Union’s 7th Framework Programme (FP7/2007–2013) under grant agreement no.241447 (NAIMIT). The Cambridge Institute for Medical Research (CIMR) is in receipt of a Wellcome Trust Strategic Award (WT100140). X.C.D. was a University of Cambridge/Wellcome Trust Infection and Immunity PhD student. R.C.F. is funded by a JDRF post-doctoral fellowship (3-2011-374). C.W. and H.G are funded by the Wellcome Trust (WT089989). The BABYDIET study was supported by grants from the Deutsche Forschungsgemeinschaft (DFG ZI-310/14-1 to-4), the JDRF (JDRF 17-2012-16 and 1-2006-665) and the German Center for Diabetes Research (DZD e.V.). E.B. is supported by the DFG Research Center and Cluster of Excellence—Center for Regenerative Therapies Dresden (FZ 111).This is the final published version. It first appeared at http://www.nature.com/ncomms/2015/150512/ncomms8000/full/ncomms8000.html
Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes
IFIH1 (interferon induced with helicase C domain 1), also known as MDA5 (melanoma differentiation-associated protein 5), is one of a family of intracellular proteins known to recognise viral RNA and mediate the innate immune response. IFIH1 is causal in type 1 diabetes based on the protective associations of four rare variants, where the derived alleles are predicted to reduce gene expression or function. Originally, however, T1D protection was mapped to the common IFIH1 nsSNP, rs1990760 or Thr946Ala. This common amino acid substitution does not cause a loss of function and evidence suggests the protective allele, Ala946, may mark a haplotype with reduced expression of IFIH1 in line with the protection conferred by the four rare loss of function alleles. We have performed allele specific expression analysis that supports this hypothesis: the T1D protective haplotype correlates with reduced IFIH1 transcription in interferon-β stimulated peripheral blood mononuclear cells (overall p = 0.012). In addition, we have used multiflow cytometry analysis and quantitative PCR assays to prove reduced expression of IFIH1 in individuals heterozygous for three of the T1D-associated rare alleles: a premature stop codon, rs35744605 (Glu627X) and predicted splice variants, rs35337543 (IVS8+1) and rs35732034 (IVS14+1). We also show that the nsSNP, Ile923V, does not alter pre-mRNA levels of IFIH1. These results confirm and extend the new autoimmune disease pathway of reduced IFIH1 expression and protein function protecting from T1D
Ecological Complex Systems
Main aim of this topical issue is to report recent advances in noisy
nonequilibrium processes useful to describe the dynamics of ecological systems
and to address the mechanisms of spatio-temporal pattern formation in ecology
both from the experimental and theoretical points of view. This is in order to
understand the dynamical behaviour of ecological complex systems through the
interplay between nonlinearity, noise, random and periodic environmental
interactions. Discovering the microscopic rules and the local interactions
which lead to the emergence of specific global patterns or global dynamical
behaviour and the noises role in the nonlinear dynamics is an important, key
aspect to understand and then to model ecological complex systems.Comment: 13 pages, Editorial of a topical issue on Ecological Complex System
to appear in EPJ B, Vol. 65 (2008