Unboosted fosamprenavir is associated with low drug exposure in HIV-infected patients with mild-moderate liver impairment resulting from HCV-related cirrhosis--authors' response

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Reply to discussion by G. Carosi and H. Chanson on "Turbulence characteristics in skimming flows on stepped spillways"

A main technical issue seems to be associated with the structure of the two-phase air–water flow skimming over the pseudo-bottom formed by the step edges. This is a difficult topic. In the air–water skimming flow, the microscopic structure of the gas–liquid mixture is closely linked with the interactions between turbulent vortices and air–water entities (bubbles, droplets, packets) (e.g., Chanson and Toombes 2002; Carosi and Chanson 2008; Gonzalez and Chanson 2008). In the high-velocity free-surface flow, the strong interactions between the turbulent waters and the atmosphere lead to a complete deformation at the interface. Through the free-surface, air is continuously trapped, and the resulting air–water mixture extends through the entire flow (Rao and Kobus 1971; Wood 1991; Chanson 1997). The air–water flow is characterized a complicated two-phase turbulent motion with void fractions ranging from some small, often nonzero values close to the invert to 100% above a pseudo "free-surface" that is usually defined as the location where the void fraction equals 90% (Cain and Wood 1981; Wood 1991; Chanson 1997; Matos 2000). The notion of "effective homogenous flow" contradicts detailed measurements conducted with accurate instrumentations in large-size facilities with well-controlled flow conditions and it is obsolete. Recent findings (Carosi and Chanson 2008) demonstrated in fact a marked changed in flow properties for C ~ 0.95 to 0.97, that is consistent with earlier studies suggesting the use of Y95 or even Y98 as the characteristic air–water flow thickness (Jevdjevich and Levin 1953; Aivazyan 1986)

Axions and the Strong CP Problem

Current upper bounds of the neutron electric dipole moment constrain the physically observable quantum chromodynamic (QCD) vacuum angle $|\bar\theta| \lesssim 10^{-11}$. Since QCD explains vast experimental data from the 100 MeV scale to the TeV scale, it is better to explain this smallness of $|\bar\theta|$ in the QCD framework, which is the strong \Ca\Pa problem. Now, there exist two plausible solutions to this problem, one of which leads to the existence of the very light axion. The axion decay constant window, $10^9\ {\gev}\lesssim F_a\lesssim 10^{12} \gev$for a${\cal O}(1)$initial misalignment angle$\theta_1$, has been obtained by astrophysical and cosmological data. For$F_a\gtrsim 10^{12}$GeV with$\theta_1<{\cal O}(1)$, axions may constitute a significant fraction of dark matter of the universe. The supersymmetrized axion solution of the strong \Ca\Pa problem introduces its superpartner the axino which might have affected the universe evolution significantly. Here, we review the very light axion (theory, supersymmetrization, and models) with the most recent particle, astrophysical and cosmological data, and present prospects for its discovery.Comment: 47 pages with 32 figure

Evaluation of the impact of separative collection and recycling of municipal solid waste on performance: An empirical application for Chile

The collection of municipal solid waste (MSW) is a public service with notable effects on the environment and public health. The objective of this study was to evaluate the impact of selective collection and recycling of MSW on the performance of municipalities in providing MSW services. By employing the data envelopment analysis method, the efficiency and eco-efficiency scores for a sample of 298 municipalities in Chile were analyzed and compared. The efficiency estimation focused on the economic performance of the municipalities in the provision of MSW services, whereas the eco-efficiency assessment also integrated the environmental performance. The results indicated that the selective collection and recycling of MSW had a significant impact on the performance of the municipalities in providing these services. The percentages of efficient and ecoefficient municipalities were very low (4.70% and 4.36%, respectively), thus demonstrating the large room for performance improvement by Chilean municipalities in the management of MSW. The efficient and eco-efficient municipalities were heterogeneously distributed throughout the country, revealing the lack of collaboration between municipalities at the regional level. Finally, exogenous variables to the management of MSW carried out by the municipalities, including the population served, population density, tourism and waste generated per capita, all had an impact on the efficiency and eco-efficiency scores. The results and conclusions of this study are of great relevance for policy makers at the regional and local levels to improve the management of MSW in the context of a circular economy

A Search for Scalar Chameleons with ADMX

Scalar fields with a "chameleon" property, in which the effective particle mass is a function of its local environment, are common to many theories beyond the standard model and could be responsible for dark energy. If these fields couple weakly to the photon, they could be detectable through the "afterglow" effect of photon-chameleon-photon transitions. The ADMX experiment was used in the first chameleon search with a microwave cavity to set a new limit on scalar chameleon-photon coupling excluding values between 2*10^9 and 5*10^14 for effective chameleon masses between 1.9510 and 1.9525 micro-eV.Comment: 4 pages, 3 figure

A SQUID-based microwave cavity search for dark-matter axions

Axions in the micro eV mass range are a plausible cold dark matter candidate and may be detected by their conversion into microwave photons in a resonant cavity immersed in a static magnetic field. The first result from such an axion search using a superconducting first-stage amplifier (SQUID) is reported. The SQUID amplifier, replacing a conventional GaAs field-effect transistor amplifier, successfully reached axion-photon coupling sensitivity in the band set by present axion models and sets the stage for a definitive axion search utilizing near quantum-limited SQUID amplifiers.Comment: 4 pages, 5 figures, submitted to PR

Vacuum Polarization and the Electric Charge of the Positron

We show that higher-order vacuum polarization would contribute a measureable net charge to atoms, if the charges of electrons and positrons do not balance precisely. We obtain the limit $|Q_e+Q_{\bar e}| < 10^{-18} e$ for the sum of the charges of electron and positron. This also constitutes a new bound on certain violations of PCT invariance.Comment: 9 pages, 1 figure attached as PostScript file, DUKE-TH-92-38. Revised versio

Quark mass uncertainties revive KSVZ axion dark matter

The Kaplan-Manohar ambiguity in light quark masses allows for a larger uncertainty in the ratio of up to down quark masses than naive estimates from the chiral Lagrangian would indicate. We show that it allows for a relaxation of experimental bounds on the QCD axion, specifically KSVZ axions in the $2-3 \mu$eV mass range composing 100% of the galactic dark matter halo can evade the experimental limits placed by the ADMX collaboration.Comment: 9 pages, 5 figure