The changing pattern of human brucellosis: clinical manifestations, epidemiology, and treatment outcomes over three decades in Georgia

<p>Abstract</p> <p>Background</p> <p>Brucellosis is an endemic infection in Georgia. We conducted a review of patient records with a suspected or confirmed diagnosis of brucellosis over three decades at the central referral hospital for brucellosis cases, the Institute of Parasitology and Tropical Medicine (IPTM) in Tbilisi. The purpose was to describe the demographic profile and clinical characteristics as well as diagnostic and treatment strategies in patients with brucellosis.</p> <p>Methods</p> <p>Data were abstracted from randomly selected patient records at the IPTM. In total, 300 records were reviewed from three time periods: 1970-73, 1988-89, and 2004-2008.</p> <p>Results</p> <p>The age distribution of patients shifted from a median age of 40 years in the first time period to 20 years in the third time period. Azeri ethnicity was an increasing proportion of the total number of cases. The frequency of relapsed infection was 14.7% (44 cases). A total of 50 patients received vaccine therapy, and although the vaccine produced immune responses, demonstrated by an increase in agglutination titers, it was not associated with improved outcome.</p> <p>Conclusion</p> <p>The demographics of brucellosis in Georgia fit a profile of persons that tend sheep. Osteoarticular complications were commonly detected, especially in children. The changing pattern of brucellosis in Georgia suggests clinicians should be updated about different trends in brucellosis in their country.</p

Karst map of Georgia (Caucasus region) scale: 1:1,500,000

Karst landscapes develop in soluble rocks, such as carbonates and evaporates, but also in various types of rocks that develop pseudokarst features. The main aim of this work is to introduce a new karst map of Georgia (scale: 1:1,500,000) presenting karst and pseudokarst features, which occupy about 17.9% (12,454 km2) of the entire territory of the country and include over 1500 known caves. We distinguish two types of karst features—karst (developed in carbonate rocks) and pseudokarst, and also five subtypes, mainly based on their lithology. About 10.2% (7120 km2) of the country is occupied by karst (carbonate rocks), and about 7.7% (5334 km2) of the country is occupied by pseudokarst features. This karst map of Georgia will provide important assistance to local and foreign researchers interested in studying Georgian karst features