2,307 research outputs found
All That is Gold Does Not Glitter in Human Clinical Research: A Law-Policy Proposal to Brighten the Global Gold Standard for Drug Research and Development
This Article challenges the global science standard for putting new drugs on pharmacy shelves. The primary premise is that the gold standard of group experimental design is an antiquated extension of drug development\u27s crude-science past, and is inconsistent with the precision of contemporary genetics-the science that increasingly dominates the drug development pipeline. The Article identifies law-policy options that would raise the standard for human clinical research under the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
All That is Gold Does Not Glitter in Human Clinical Research: A Law-Policy Proposal to Brighten the Global Gold Standard for Drug Research and Development
This Article challenges the global science standard for putting new drugs on pharmacy shelves. The primary premise is that the gold standard of group experimental design is an antiquated extension of drug development\u27s crude-science past, and is inconsistent with the precision of contemporary genetics-the science that increasingly dominates the drug development pipeline. The Article identifies law-policy options that would raise the standard for human clinical research under the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
All that is Gold Does Not Glitter in Human Clinical Research: A Law– Policy Proposal to Brighten the Global “Gold Standard” for Drug Research and Development
This Article challenges the global science standard for putting new drugs on pharmacy shelves. The primary premise is that the “gold standard” of group experimental design is an antiquated extension of drug development’s crude-science past, and is inconsistent with the precision of contemporary genetics— the science that increasingly dominates the drug development pipeline. The Article identifies law– policy options that would raise the standard for human clinical research under the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
Drug Development—Stuck in a State of Puberty?: Regulatory Reform of Human Clinical Research to Raise Responsiveness to the Reality of Human Variability
Two types of all-optical magnetization switching mechanisms using femtosecond laser pulses
Magnetization manipulation in the absence of an external magnetic field is a
topic of great interest, since many novel physical phenomena need to be
understood and promising new applications can be imagined. Cutting-edge
experiments have shown the capability to switch the magnetization of magnetic
thin films using ultrashort polarized laser pulses. In 2007, it was first
observed that the magnetization switching for GdFeCo alloy thin films was
helicity-dependent and later helicity-independent switching was also
demonstrated on the same material. Recently, all-optical switching has also
been discovered for a much larger variety of magnetic materials (ferrimagnetic,
ferromagnetic films and granular nanostructures), where the theoretical models
explaining the switching in GdFeCo films do not appear to apply, thus
questioning the uniqueness of the microscopic origin of all-optical switching.
Here, we show that two different all-optical switching mechanisms can be
distinguished; a "single pulse" switching and a "cumulative" switching process
whose rich microscopic origin is discussed. We demonstrate that the latter is a
two-step mechanism; a heat-driven demagnetization followed by a
helicity-dependent remagnetization. This is achieved by an all-electrical and
time-dependent investigation of the all-optical switching in ferrimagnetic and
ferromagnetic Hall crosses via the anomalous Hall effect, enabling to probe the
all-optical switching on different timescales.Comment: 1 page, LaTeX; classified reference number
Magnetization dynamics and Gilbert damping in ultrathin Co48Fe32B20 films with out-of-plane anisotropy
Time resolved magneto-optical Kerr measurements are carried out to study the precessional dynamics of ferromagnetic thin films with out-of-plane anisotropy. A combined analysis of parameters, such as coercive fields, magnetic anisotropy, and Gilbert damping a, is reported. Using a macrospin approximation and the Landau-Lifshitz-Gilbert equation, the effective anisotropy and a are obtained. A large damping varying with the applied field as well as with the thickness of the ferromagnetic layer is reported. Simulations using a distribution in the effective anisotropy allow us to reproduce the field evolution of a. Moreover, its thickness dependence correlates with the spin pumping effect. © 2009 American Institute of Physics
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