Antibiotic resistance – a modern global health problem. The search for possible solutions in treating PID

Loss of medical control over infections that were previously considered harmless or easy managed in most patients can be considered a challenge for the modern medicine. Along with the intensification of pathogenic properties, opportunistic pathogens acquire resistance factors to antimicrobial agents - antibiotics. At the same time, the prevalence of pelvic inflammatory diseases (PID) accounts for about 50 to 65% among women of childbearing age and has no tendency to decline. On top of that, non-specific chronic diseases of the genital tract are more common than infections caused by absolute pathogens. Ineffective therapy of acute forms of the disease leads to the emergence of resistant forms of pathogens, recurrence of the disease and chronic inflammation. The development of secondary immunodeficiency characterized by improper cellular and humoral immune functions plays an important role in the pathogenesis of chronic inflammatory diseases of the urogenital tract. That is why the treatment of chronic inflammatory diseases of the genital tract should be complex and include etiotropic chemotherapeutic agents aimed at eliminating the pathogens, and the immunomodulating agents aimed at normalizing the functional activity of the patient’s immune system

Magnesium supplementation during pregnancy

Magnesium is a unique microelement in the human body which is necessary for all organs and systems to be sustained. During pregnancy, the need for magnesium is significantly increased due to functioning of the mother-placenta-fetus system, the intrauterine growth and development of the fetus. Maternal hypomagnesemia during pregnancy is associated with an increased risk of placental insufficiency, delayed fetal growth, threatened abortion, premature birth, gestational diabetes, and preeclampsia. Given the high prevalence of magnesium deficiency among pregnant women (up to 81.2%), it is necessary to conduct a timely assessment of the magnesium status of all pregnant women and, if necessary, to conduct timely therapy aimed at replenishing the magnesium deficiency. In the treatment of magnesium deficiency we would recommend organic magnesium salts, such as magnesium citrate, as it has the highest solubility and bioavailability