4,850 research outputs found
Enhancement of the Deuteron-Fusion Reactions in Metals and its Experimental Implications
Recent measurements of the reaction d(d,p)t in metallic environments at very
low energies performed by different experimental groups point to an enhanced
electron screening effect. However, the resulting screening energies differ
strongly for divers host metals and different experiments. Here, we present new
experimental results and investigations of interfering processes in the
irradiated targets. These measurements inside metals set special challenges and
pitfalls which make them and the data analysis particularly error-prone. There
are multi-parameter collateral effects which are crucial for the correct
interpretation of the observed experimental yields. They mainly originate from
target surface contaminations due to residual gases in the vacuum as well as
from inhomogeneities and instabilities in the deuteron density distribution in
the targets. In order to address these problems an improved differential
analysis method beyond the standard procedures has been implemented. Profound
scrutiny of the other experiments demonstrates that the observed unusual
changes in the reaction yields are mainly due to deuteron density dynamics
simulating the alleged screening energy values. The experimental results are
compared with different theoretical models of the electron screening in metals.
The Debye-H\"{u}ckel model that has been previously proposed to explain the
influence of the electron screening on both nuclear reactions and radioactive
decays could be clearly excluded.Comment: 22 pages, 12 figures, REVTeX4, 2-column format. Submitted to Phys.
Rev. C; accepte
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray
The identification of novel genes or groups of genes expressed in prostate cancer may allow earlier diagnosis or more accurate staging of the disease. We describe the assembly and use of a 1877-member microarray representing cDNA clones from a range of prostate cancer stages and grades, precursor lesions and normal tissue. Using labelled cDNA from tumour samples obtained from TURP or radical prostatectomy, analysis of expression patterns identified many up-regulated transcripts. Cell lines were found to over-express fewer genes than diseased tissue samples. 17 known genes were found to over-express more than 4-fold in 4 or more cancers out of 15 cancers. Only 2 genes were over-expressed in 6 out of 15 cancers or more, whilst no genes were consistently found to be over-expressed in all cancer samples. Novel prostate cancer associations for several well characterized genes or full length cDNAs were identified, including PLRP1, JM27, human UbcM2, dynein light intermediate chain 2 and human homologue of rat sec61. Novel associations with high-grade PIN include: breast carcinoma fatty acid synthase and cDNA DKFZp434B0335. We shortlist and discuss the most significant over-expressed genes in prostate cancer and PIN, and highlight expression differences between malignant and benign samples. © 2001 Cancer Research Campaign http://www.bjcancer.co
Development of Stresses in Cohesionless Poured Sand
The pressure distribution beneath a conical sandpile, created by pouring sand
from a point source onto a rough rigid support, shows a pronounced minimum
below the apex (`the dip'). Recent work of the authors has attempted to explain
this phenomenon by invoking local rules for stress propagation that depend on
the local geometry, and hence on the construction history, of the medium. We
discuss the fundamental difference between such approaches, which lead to
hyperbolic differential equations, and elastoplastic models, for which the
equations are elliptic within any elastic zones present .... This displacement
field appears to be either ill-defined, or defined relative to a reference
state whose physical existence is in doubt. Insofar as their predictions depend
on physical factors unknown and outside experimental control, such
elastoplastic models predict that the observations should be intrinsically
irreproducible .... Our hyperbolic models are based instead on a physical
picture of the material, in which (a) the load is supported by a skeletal
network of force chains ("stress paths") whose geometry depends on construction
history; (b) this network is `fragile' or marginally stable, in a sense that we
define. .... We point out that our hyperbolic models can nonetheless be
reconciled with elastoplastic ideas by taking the limit of an extremely
anisotropic yield condition.Comment: 25 pages, latex RS.tex with rspublic.sty, 7 figures in Rsfig.ps.
Philosophical Transactions A, Royal Society, submitted 02/9
Higher analogues of the discrete-time Toda equation and the quotient-difference algorithm
The discrete-time Toda equation arises as a universal equation for the
relevant Hankel determinants associated with one-variable orthogonal
polynomials through the mechanism of adjacency, which amounts to the inclusion
of shifted weight functions in the orthogonality condition. In this paper we
extend this mechanism to a new class of two-variable orthogonal polynomials
where the variables are related via an elliptic curve. This leads to a `Higher
order Analogue of the Discrete-time Toda' (HADT) equation for the associated
Hankel determinants, together with its Lax pair, which is derived from the
relevant recurrence relations for the orthogonal polynomials. In a similar way
as the quotient-difference (QD) algorithm is related to the discrete-time Toda
equation, a novel quotient-quotient-difference (QQD) scheme is presented for
the HADT equation. We show that for both the HADT equation and the QQD scheme,
there exists well-posed -periodic initial value problems, for almost all
\s\in\Z^2. From the Lax-pairs we furthermore derive invariants for
corresponding reductions to dynamical mappings for some explicit examples.Comment: 38 page
Quantum theory's last challenge
Quantum mechanics is now 100 years old and still going strong. Combining
general relativity with quantum mechanics is the last hurdle to be overcome in
the "quantum revolution".Comment: (9 pages, LaTex) This is the preprint version of an article that
appeared in the issue 6813 (volume 408) of Nature, as part of a 3-article
celebration of the 100th anniversary of Planck's solution of the
black-body-radiation proble
On the tau-functions of the Degasperis-Procesi equation
The DP equation is investigated from the point of view of
determinant-pfaffian identities. The reciprocal link between the
Degasperis-Procesi (DP) equation and the pseudo 3-reduction of the
two-dimensional Toda system is used to construct the N-soliton solution of the
DP equation. The N-soliton solution of the DP equation is presented in the form
of pfaffian through a hodograph (reciprocal) transformation. The bilinear
equations, the identities between determinants and pfaffians, and the
-functions of the DP equation are obtained from the pseudo 3-reduction of
the two-dimensional Toda system.Comment: 27 pages, 4 figures, Journal of Physics A: Mathematical and
Theoretical, to be publishe
Influence of dissipation on the extraction of quantum states via repeated measurements
A quantum system put in interaction with another one that is repeatedly
measured is subject to a non-unitary dynamics, through which it is possible to
extract subspaces. This key idea has been exploited to propose schemes aimed at
the generation of pure quantum states (purification). All such schemes have so
far been considered in the ideal situations of isolated systems. In this paper,
we analyze the influence of non-negligible interactions with environment during
the extraction process, with the scope of investigating the possibility of
purifying the state of a system in spite of the sources of dissipation. A
general framework is presented and a paradigmatic example consisting of two
interacting spins immersed in a bosonic bath is studied. The effectiveness of
the purification scheme is discussed in terms of purity for different values of
the relevant parameters and in connection with the bath temperature.Comment: 10 pages, 3 figure
No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7–19 years
Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for islet cell antibodies. Anti-coxsackie B1-5 IgM responses were detected in 14 of 44 (32%) of the islet cell antibody-positive subjects and in 7 of 44 (16%) control subjects. This difference did not reach the level of statistical significance. None of the islet cell antibody-positive subjects had specific IgM antibodies to mumps, rubella, or cytomegalovirus. There was also no increase in the prevalence or the mean titres of anti-mumps-IgG or IgA and anti-cytomegalovirus-IgG in islet cell antibody-positive subjects compared to control subjects. These results do not suggest any association between islet cell antibodies, and possibly insulitis, with recent mumps, rubella or cytomegalo virus infection. Further studies are required to clarify the relationship between islet cell antibodies and coxsackie B virus infections
Comparing temporal patterns in body condition of ringed seals living within their core geographic range with those living at the edge
Ecological theory suggests that demographic responses by populations to environmental change vary depending on whether individuals inhabit central or peripheral regions within the species’ geographic range. Here, we tested this prediction by comparing a population of ringed seals Pusa hispida located at high latitudes as part of their core range (core) with a population located at the southern extremity of their range (peripheral). First, we compared the two regions’ environmental trends in timing of sea-ice breakup and freeze-up, open-water duration and the North Atlantic Oscillation (NAO). We found that the core region shifted to progressively warmer conditions in the early 1990s; whereas, in the peripheral region, the warming trend shifted in 1999 to one with no warming trend but high inter-annual variability. Next, we examined how body condition, inferred from blubber depth, responded to temporal changes in sea-ice and climatic variables – variables that have been shown to influence ringed seal demography. Core seals displayed minimal seasonal changes in body condition; whereas peripheral seals displayed a 20–60% amplitude seasonal change in body condition with a phase shift to earlier initiation of fat accumulation and loss. Finally, we tested for interannual differences and found that both core and peripheral seals responded similarly with decreased body condition following more positive NAO. Environmental variables influenced body condition in opposite directions between the two regions with core seals declining in body condition with later spring breakup and shorter open-water duration, whereas peripheral seals showed opposite relationships. Seals living at the core likely benefit from an evolved match between adaptation and environmental variation resulting in dampened seasonal and interannual fluctuations in body condition. Knowledge of how different populations respond to environmental change depending on geographic location within a species range can assist in anticipating population specific responses to climate warming
MRI and CT imaging biomarkers of cerebral amyloid angiopathy in lobar intracerebral hemorrhage
BACKGROUND: Cerebral amyloid angiopathy (CAA), a common cause of intracerebral hemorrhage (ICH), is diagnosed using the Boston criteria including magnetic resonance imaging (MRI) biomarkers (cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS). The simplified Edinburgh criteria include computed tomography (CT) biomarkers (subarachnoid extension (SAE) and finger-like projections (FLPs)). The underlying mechanisms and diagnostic accuracy of CT compared to MRI biomarkers of CAA are unknown. METHODS: We included 140 survivors of spontaneous lobar supratentorial ICH with both acute CT and MRI. We assessed associations between MRI and CT biomarkers and the diagnostic accuracy of CT- compared to MRI-based criteria. RESULTS: FLPs were more common in patients with strictly lobar CMB (44.7% vs 23.5%; p = 0.014) and SAE was more common in patients with cSS (61.3% vs 31.2%; p = 0.002). The high probability of the CAA category of the simplified Edinburgh criteria showed 87.2% (95% confidence interval (CI): 78.3-93.4) specificity, 29.6% (95% CI: 18.0-43.6) sensitivity, 59.3% (95% CI: 38.8-77.6) positive predictive value, and 66.4% (95%: CI 56.9-75.0) negative predictive value, 2.3 (95% CI: 1.2-4.6) positive likelihood ratio and 0.8 (95% CI 0.7-1.0) negative likelihood ratio for probable CAA (vs non-probable CAA), defined by the modified Boston criteria; the area under the receiver operating characteristic curve (AUROC) was 0.62 (95% CI: 0.54-0.71). CONCLUSION: In lobar ICH survivors, we found associations between putative biomarkers of parenchymal CAA (FLP and strictly lobar CMBs) and putative biomarkers of leptomeningeal CAA (SAE and cSS). In a hospital population, CT biomarkers might help rule-in probable CAA (diagnosed using the Boston criteria), but their absence is probably not as useful to rule it out, suggesting an important continued role for MRI in ICH survivors with suspected CAA
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