Die Bedeutung der Neurobiologie für die Kinder- und Jugendlichentherapie

Welche Bedeutung haben die in den letzten beiden Jahrzehnten erarbeiteten neurobiologischen Forschungsergebnisse für die Praxis der Kinder- und Jugendlichentherapie? Das ist die Frage, mit der ich mich im Folgenden beschäft igen möchte. Ich selber schwanke immer zwischen zwei Extremen: Einerseits fi nde ich es faszinierend, über neuere neurobiologische Erkenntnisse zu lesen und ihre Bedeutung für die Psychotherapie mit Kindern und Jugendlichen zu refl ektieren. Andererseits habe ich oft den Eindruck, dass die zweifellos beeindruckenden Forschungsmethoden doch nur sehr eingeschränkt in der Lage sind, etwas von der Komplexität der Vorgänge im Gehirn zu erfassen. Sie fordern die Forscher damit zu Interpretationen heraus mit der Folge, dass manche von ihnen darin genau das entdecken, wovon sie vorher überzeugt waren. Sicherlich kommen umfangreiche neurobiologische Forschungen in vielen Fällen auch zu Ergebnissen, die aufgrund des inzwischen doch sehr großen psychotherapeutischen Erfahrungsschatzes ziemlich selbstverständlich, sozusagen als alte Hüte wirken. Das mindert mein persönliches Interesse allerdings nicht. Denn nach meiner Erfahrung ist es oft sehr bereichernd, auch alte Hüte mal von einer anderen Seite und unter anderen Aspekten zu betrachten. Und ich erlebe es als sehr spannend zu beobachten, welche Teile dieses therapeutischen Erfahrungsschatzes sich nicht bestätigen werden

Effects of malt bagasse utilization on kale germination using different substrates and shadings.

Malt bagasse is an important waste from breweries, with high potential of usage in various animal and human food areas. Nonetheless, there are few studies of its in natura usage as soil conditioner for various vegetables seedings production. Thus, this works objective was evaluate the interaction among different substrate compositions, using brewery waste as component, and different shading levels at Georgian cabbage germination. For that, the experiment was made in five different shading levels (50%, 70%, 90%, 70% with plastic and full sun) and three different substrates moistures with distinct compositions: S1 (33,33% of manure; 33,33% of sandy soil; 33,33% of clayish soil), S2 (83% of earthworm humus; 15% of fine glyceride charcoal; 2% of mammon dumpling), S3 (33,33% of brew waste; 33,33% of sandy soil; 33,33% of clayish soil), in an completely randomized design, with five repetitions for each shading level and substrate concentration. Germination beginning occurred in the third day after sowing (DAS) and lasted until the tenth DAS. The S2 substrate stood out, followed by S1, with similar results in height, roots length, germination percentage, and germination speed index. On the other hand, the substrate composed of malt bagasse obtained the worst results in all shading conditions, being not indicated to kale seedings production

Spontaneous and radiation-induced chromosomal instability and persistence of chromosome aberrations after radiotherapy in lymphocytes from prostate cancer patients

The aim of the study was to compare the spontaneous and ex vivo radiation-induced chromosomal damage in lymphocytes of untreated prostate cancer patients and age-matched healthy donors, and to evaluate the chromosomal damage, induced by radiotherapy, and its persistence. Blood samples from 102 prostate cancer patients were obtained before radiotherapy to investigate the excess acentric fragments and dicentric chromosomes. In addition, in a subgroup of ten patients, simple exchanges in chromosomes 2 and 4 were evaluated by fluorescent in situ hybridization (FISH), before the onset of therapy, in the middle and at the end of therapy, and 1 year later. Data were compared to blood samples from ten age-matched healthy donors. We found that spontaneous yields of acentric chromosome fragments and simple exchanges were significantly increased in lymphocytes of patients before onset of therapy, indicating chromosomal instability in these patients. Ex vivo radiation-induced aberrations were not significantly increased, indicating proficient repair of radiation-induced DNA double-strand breaks in lymphocytes of these patients. As expected, the yields of dicentric and acentric chromosomes, and the partial yields of simple exchanges, were increased after the onset of therapy. Surprisingly, yields after 1 year were comparable to those directly after radiotherapy, indicating persistence of chromosomal instability over this time. Our results indicate that prostate cancer patients are characterized by increased spontaneous chromosomal instability. This instability seems to result from defects other than a deficient repair of radiation-induced DNA double-strand breaks. Radiotherapy-induced chromosomal damage persists 1 year after treatment

Simulation and experimental study of proton bunch self-modulation in plasma with linear density gradients

We present numerical simulations and experimental results of the self-modulation of a long proton bunch in a plasma with linear density gradients along the beam path. Simulation results agree with the experimental results reported [F. Braunmller, T. Nechaeva et al. (AWAKE Collaboration), Phys. Rev. Lett. 125, 264801 (2020)PRLTAO0031-900710.1103/PhysRevLett.125.264801]: with negative gradients, the charge of the modulated bunch is lower than with positive gradients. In addition, the bunch modulation frequency varies with gradient. Simulation results show that dephasing of the wakefields with respect to the relativistic protons along the plasma is the main cause for the loss of charge. The study of the modulation frequency reveals details about the evolution of the self-modulation process along the plasma. In particular for negative gradients, the modulation frequency across time-resolved images of the bunch indicates the position along the plasma where protons leave the wakefields. Simulations and experimental results are in excellent agreement