418 research outputs found
Inverse Cascade Evidenced by Information Entropy of Passive Scalars in Submerged Canopy Flows
Turbulent mixing of scalars within canopies is investigated using a flume experiment with canopy-like rods of height h mounted to the channel bed. The data comprised a time sequence of high-resolution images of a dye recorded in a plane parallel to the bed at z/h= 0.2. Image processing shows that von KĂĄrmĂĄn wakes shed by canopy drag and downward turbulent transport from upper canopy layers impose distinct scaling regimes on the scalar spectrum. Measures from information theory are then used to explore the dominant directionality of the interaction between small and large scales underlying these two spectral regimes, showing that the arrival of sweeps from aloft establishes an inertial-range spectrum with forward âinformationâ cascade. In contrast, wake growth with downstream distance leads to persistent upscale transfer (inverse cascade) of scalar variance, which hints at their nondiffusive character and the significance of the stem diameter as an active length scale in canopy turbulence
Evaluation of Immunomodulatory Biomarkers in a Pressure Overload Model of Heart Failure
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90380/1/phco.27.4.504.pd
Net Effects: Examining Strategies for Womenâs Inclusion and Influence in ASX200 Company Boards
Net effects: examining strategies for womenâs inclusion and influence in ASX200 company boards
Empathy, education and awareness: A VR hackathonâs approach to tackling climate change
Climate change education is crucial for fostering informed and engaged future generations. However, traditional pedagogies often fail to engage learners fully and provide real-world, experiential learning. This paper presents a novel approach to climate change education through a three-day virtual reality (VR) hackathon. The hackathon focused on four United Nations (UN) Sustainable Development Goals (SDGs)âQuality Education, Affordable and Clean Energy, Sustainable Cities and Communities, and Climate Action. Using VR technology and game design software, engineering students worked in teams. They competed against each other in designing immersive environments that demonstrated their understanding of these SDGs and climate change. Our goal was to encourage the development of empathy, education, and awareness around these critical global issues. The hackathon also integrated authentic assessments, mirroring real-world engineering tasks and providing a more practical and relevant learning experience. Our findings suggest that this VR hackathon has significantly enhanced studentsâ understanding of the SDGs and climate change issues, their competency with VR technologies, as well as their teamwork and problem-solving skills. This paper discusses the hackathonâs design, implementation, and outcomes, highlighting the potential of such innovative approaches in tackling climate change education and awareness
Nebulized antibiotics for ventilator-associated pneumonia: misleading analysis and interpretation of the data
Optimization of Key Parameters Towards High Performance Perovskite Solar Cells
Here, we report important findings regarding underestimated parameters for the synthesis and fabrication of high-performance perovskite solar cells. These parameters include the effect of Fluorine-doped Tin Oxide (FTO) etching, FTO cleaning, the number of compact TiO 2 (c-TiO 2 ) layer, the number of mesoporous TiO 2 (m-TiO 2 ) layers and the aging time before Ag deposition. Our results demonstrated that etching of FTO substrate with Zn/HCl is an essential step and has a major effect on the solar cell's open circuit voltage (Voc), fill factor (FF) and power conversion efficiency (PCE). Furthermore, we demonstrate new and improved protocols for the complete cleaning of FTO substrates. Despite the use of sonication and plasma etching in previous cleaning techniques, SEM images clearly show black clouds in the samples, which may be due to residual Zn particles in the FTO grooves. Thus, a soft toothbrush was used with detergent before sonication to detach the remaining Zn particles. In addition, the optimum number of spin coated layers of compact and mesoporous TiO 2 precursors was investigated. We found that one mesoporous and two compact TiO 2 layers were required to obtain a homogenous pinhole-free compact layer. Consequently, we demonstrate that using these optimized device fabrication procedures, a high efficiency of 17.96% for 6 mol% Co 3+ -doped TiO 2 solar cells can be obtained in comparison to 16.98% for pristine TiO 2 -based cells. Such cells are particularly important for wearable applications that require a small area and a high energy
Optimization of organic meso-superstructured solar cells for underwater IoT² self-powered sensors
The effectiveness of the mesoporous TiOâ layer, which acts as an active n-type semiconductor layer in dye-sensitized solar cells (DSSCs), was investigated by varying AgVOâ doping. To optimize the meso-superstructure, the doping concentration was varied from 0% to 25% using experimentally validated simulations. Moreover, performance comparisons between the experimentally fabricated DSSCs based on natural beetroot dye and the commonly used N719 dye were made. A 15% doping concentration was found optimum for our DSSC, which delivered an output power of 19.24 mW, 6.1% power conversion efficiency, and an open-circuit voltage, Voc , of 0.5 V and a short-circuit current density, Jsc , of 21 mA/cm² in diffused light conditions. Based on these performance results, we integrated our optimized DSSC in an underwater sensing unit as a light harvester
Discovery of a solâgel reinforcing the strength of hair structure: mechanisms of action and macroscopic effects on the hair
Intrinsic NLRP3 inflammasome activity is critical for normal adaptive immunity via regulation of IFN-Îł in CD4+ T cells
The NLRP3 inflammasome controls interleukin-1b maturation in antigen-presenting cells, but
a direct role for NLRP3 in human adaptive immune cells has not been described.We found that
the NLRP3 inflammasome assembles in human CD4+ Tcells and initiates caspase-1âdependent
interleukin-1b secretion, thereby promoting interferon-g production and T helper 1 (TH1)
differentiation in an autocrine fashion. NLRP3 assembly requires intracellular C5 activation and
stimulation of C5a receptor 1 (C5aR1), which is negatively regulated by surface-expressed
C5aR2. Aberrant NLRP3 activity in Tcells affects inflammatory responses in human
autoinflammatory disease and in mouse models of inflammation and infection. Our results
demonstrate that NLRP3 inflammasome activity is not confined to âinnate immune cellsâ but is
an integral component of normal adaptive TH1 responses
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