Cabergoline therapy for macroprolactinoma during pregnancy: a case report.

Background: We assessed the safety of Cabergoline therapy during pregnancy in a lady with hyperprolactinemia intolerant to Bromocriptine. Case presentation: We report the case of a 31 year old lady who presented to us with uncontrolled hyperprolactinemia. A pituitary Macroadenoma was demonstrated by MRI. Due to intolerance to Bromocriptine, Cabergoline was started. The patient improved and subsequently conceived. MRI in the second trimester demonstrated further reduction in the tumor size. It was decided to continue Cabergoline throughout pregnancy to ensure further reduction in tumor size until delivery and to hold Cabergoline during postpartum period to allow for an adequate interval of breastfeeding. At 37 weeks of gestation, the patient delivered a healthy baby. Conclusion: We were able to safely treat macroprolactinemia in our patient during pregnancy with cabergoline. This case report contributes to the relatively meager data available which advocates the safety of cabergoline therapy in pregnant hyperprolactinemic patients

A STUDY OF THE DECAYS OF TAU LEPTONS PRODUCED ON THE Z-RESONANCE AT LEP

From the analysis of a data sample corresponding to an integrated luminosity of 4.63 pb-1 taken during the 1990 run of LEP at centre of mass energies between 88.2 GeV an 94.2 GeV, the tau decays {Mathematical expression} and their charge conjugates have been studied. The following branching ratios have been measured; {Mathematical expression}, {Mathematical expression}, Br(τ- → π- (K-)vτ)=11.9±0.7±0.7%, BR (τ- → ρ- vτ)= 22.4±0.8±1.3%, in good agreement with world averages. The measured electronic and muonic branching ratios lead to a measurement of the strong coupling constant, αs (mτ) = 0.26-0.12+0.09. Extrapolating the αs value from mτ to mZ yields αs (mZ) = 0.109-0.028+0.012. The average polarization Pτ of taus produced in Z → τs τs decays has also been measured using the above decay modes. The weighted mean of the polarizations obtained from the four decay modes is Pτ=-0.24±0.07. This value of Pτ gives, in the improved Born approximation, a ratio between the axial and vector coupling constants of the tau of υτ/aτ = 0.12 ± 0.04, and hence a value of the effective electroweak mixing parameter sin2 θW(mZ2). © 1992 Springer-Verlag