15 research outputs found
A systematic review and meta-analysis to determine the contribution of mr imaging to the diagnosis of foetal brain abnormalities In Utero.
OBJECTIVES: This systematic review was undertaken to define the diagnostic performance of in utero MR (iuMR) imaging when attempting to confirm, exclude or provide additional information compared with the information provided by prenatal ultrasound scans (USS) when there is a suspicion of foetal brain abnormality. METHODS: Electronic databases were searched as well as relevant journals and conference proceedings. Reference lists of applicable studies were also explored. Data extraction was conducted by two reviewers independently to identify relevant studies for inclusion in the review. Inclusion criteria were original research that reported the findings of prenatal USS and iuMR imaging and findings in terms of accuracy as judged by an outcome reference diagnosis for foetal brain abnormalities. RESULTS: 34 studies met the inclusion criteria which allowed diagnostic accuracy to be calculated in 959 cases, all of which had an outcome reference diagnosis determined by postnatal imaging, surgery or autopsy. iuMR imaging gave the correct diagnosis in 91 % which was an increase of 16 % above that achieved by USS alone. CONCLUSION: iuMR imaging makes a significant contribution to the diagnosis of foetal brain abnormalities, increasing the diagnostic accuracy achievable by USS alone. KEY POINTS: • Ultrasound is the primary modality for monitoring foetal brain development during pregnancy • iuMRI used together with ultrasound is more accurate for detecting foetal brain abnormalities • iuMR imaging is most helpful for detecting midline brain abnormalities • The moderate heterogeneity of reviewed studies may compromise findings
Report of the Topical Group on Higgs Physics for Snowmass 2021: The Case for Precision Higgs Physics
A future Higgs Factory will provide improved precision on measurements of
Higgs couplings beyond those obtained by the LHC, and will enable a broad range
of investigations across the fields of fundamental physics, including the
mechanism of electroweak symmetry breaking, the origin of the masses and mixing
of fundamental particles, the predominance of matter over antimatter, and the
nature of dark matter. Future colliders will measure Higgs couplings to a few
per cent, giving a window to beyond the Standard Model (BSM) physics in the
1-10 TeV range. In addition, they will make precise measurements of the Higgs
width, and characterize the Higgs self-coupling. This report details the work
of the EF01 and EF02 working groups for the Snowmass 2021 study.Comment: 44 pages, 40 figures, Report of the Topical Group on Higgs Physics
for Snowmass 2021. The first four authors are the Conveners, with
Contributions from the other author
Strange quark as a probe for new physics in the Higgs sector
This paper describes a novel algorithm for tagging jets originating from the hadronisation of strange quarks (strange-tagging) with the future International Large Detector (ILD) at the International Linear Collider (ILC). It also presents the first application of such a strange-tagger to a Higgs to strange () analysis with the polarisation scenario, corresponding to 900 fb of the initial proposed 2000 fb of data which will be collected by ILD during its first 10 years of data taking at GeV. Upper limits on the Standard Model Higgs-strange coupling strength modifier, , are derived at the 95% confidence level to be 7.14. The paper includes as well a preliminary study of a Ring Imaging Cherenkov (RICH) system capable of discriminating between kaons and pions at high momenta (up to 25 GeV), and thus enhancing strange-tagging performance at future Higgs factory detectors