101,731 research outputs found
Resolved-sideband laser cooling in a penning trap
We report the laser cooling of a single ion in a Penning
trap to the motional ground state in one dimension. Cooling is performed in the
strong binding limit on the 729-nm electric quadrupole transition, broadened by a quench laser coupling the and
levels. We find the final ground state occupation to be .
We measure the heating rate of the trap to be very low with
for trap frequencies from
, consistent with the large ion-electrode distance.Comment: 4 pages, 6 figures. Accepted: Phys. Rev. Lett. (2016)
http://journals.aps.org/prl/accepted/b6074YefH1115b5881f77975417a6ae0bc9f652a
Decision Tree Analysis as a Supplementary Tool to Enhance Histomorphological Differentiation when Distinguishing Human from Non-human Cranial Bone in both Burnt and Unburnt States: A feasibility study
This feasibility study was undertaken to describe and record the histological characteristics of burnt and unburnt cranial bone fragments from human and non-human bones. Reference series of fully mineralised, transverse sections of cranial bone, from all variables and specimen states were prepared by manual cutting and semi-automated grinding and polishing methods. A photomicrograph catalogue reflecting differences in burnt and unburnt bone from human and non-humans was recorded and qualitative analysis was performed using an established classification system based on primary bone characteristics. The histomorphology associated with human and non-human samples was, for the main part, preserved following burning at high temperature. Clearly, fibro-lamellar complex tissue subtypes, such as plexiform or laminar primary bone, were only present in non-human bones. A decision tree analysis based on histological features provided a definitive identification key for distinguishing human from non-human bone, with an accuracy of 100%. The decision tree for samples where burning was unknown was 96% accurate, and multi-step classification to taxon was possible with 100% accuracy. The results of this feasibility study, strongly suggest that histology remains a viable alternative technique if fragments of cranial bone require forensic examination in both burnt and unburnt states. The decision tree analysis may provide an additional, but vital tool to enhance data interpretation. Further studies are needed to assess variation in histomorphology taking into account other cranial bones, ontogeny, species and burning conditions
A Novel Document Generation Process for Topic Detection based on Hierarchical Latent Tree Models
We propose a novel document generation process based on hierarchical latent
tree models (HLTMs) learned from data. An HLTM has a layer of observed word
variables at the bottom and multiple layers of latent variables on top. For
each document, we first sample values for the latent variables layer by layer
via logic sampling, then draw relative frequencies for the words conditioned on
the values of the latent variables, and finally generate words for the document
using the relative word frequencies. The motivation for the work is to take
word counts into consideration with HLTMs. In comparison with LDA-based
hierarchical document generation processes, the new process achieves
drastically better model fit with much fewer parameters. It also yields more
meaningful topics and topic hierarchies. It is the new state-of-the-art for the
hierarchical topic detection
Sampled Weighted Min-Hashing for Large-Scale Topic Mining
We present Sampled Weighted Min-Hashing (SWMH), a randomized approach to
automatically mine topics from large-scale corpora. SWMH generates multiple
random partitions of the corpus vocabulary based on term co-occurrence and
agglomerates highly overlapping inter-partition cells to produce the mined
topics. While other approaches define a topic as a probabilistic distribution
over a vocabulary, SWMH topics are ordered subsets of such vocabulary.
Interestingly, the topics mined by SWMH underlie themes from the corpus at
different levels of granularity. We extensively evaluate the meaningfulness of
the mined topics both qualitatively and quantitatively on the NIPS (1.7 K
documents), 20 Newsgroups (20 K), Reuters (800 K) and Wikipedia (4 M) corpora.
Additionally, we compare the quality of SWMH with Online LDA topics for
document representation in classification.Comment: 10 pages, Proceedings of the Mexican Conference on Pattern
Recognition 201
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Implications of moderate altitude training for sea level endurance in elite distance runners
Elite distance runners participated in one of
two studies designed to investigate the e ects of mod-
erate altitude training (inspiratory partial pressure of
oxygen »115±125 mmHg) on submaximal, maximal and
supramaximal exercise performance following return to
sea-level. Study 1 (New Mexico, USA) involved 14
subjects who were assigned to a 4-week altitude training
camp (1500±2000 m) whilst 9 performance-matched
subjects continued with an identical training programme
at sea-level (CON). Ten EXP subjects who trained at
1640 m and 19 CON subjects also participated in study 2
(Krugersdorp, South Africa). Selected metabolic and
cardiorespiratory parameters were determined with the
subjects at rest and during exercise 21 days prior to
(PRE) and 10 and 20 days following their return to sea-
level (POST). Whole blood lactate decreased by 23%
(P < 0.05 vs PRE) during submaximal exercise in the
EXP group only after 20 days at sea-level (study 1).
However, the lactate threshold and other measures of
running economy remained unchanged. Similarly, su-
pramaximal performance during a standardised track
session did not change. Study 2 demonstrated that
hypoxia per se did not alter performance. In contrast, in
the EXP group supramaximal running velocity de-
creased by 2% (P < 0.05) after 20 days at sea-level.
Both studies were characterised by a 50% increase in the
frequency of upper respiratory and gastrointestinal tract
infections during the altitude sojourns, and two male
subjects were diagnosed with infectious mononucleosis
following their return to sea-level (study 1). Group mean
plasma glutamine concentrations at rest decreased by
19% or 143 (74) lM (P < 0.001) after 3 weeks at alti-
tude, which may have been implicated in the increased
incidence of infectious illness
Focused Deterrence and the Prevention of Violent Gun Injuries: Practice, Theoretical Principles, and Scientific Evidence
Focused deterrence strategies are a relatively new addition to a growing portfolio of evidence-based violent gun injury prevention practices available to policy makers and practitioners. These strategies seek to change offender behavior by understanding the underlying violence-producing dynamics and conditions that sustain recurring violent gun injury problems and by implementing a blended strategy of law enforcement, community mobilization, and social service actions. Consistent with documented public health practice, the focused deterrence approach identifies underlying risk factors and causes of recurring violent gun injury problems, develops tailored responses to these underlying conditions, and measures the impact of implemented interventions. This article reviews the practice, theoretical principles, and evaluation evidence on focused deterrence strategies. Although more rigorous randomized studies are needed, the available empirical evidence suggests that these strategies generate noteworthy gun violence reduction impacts and should be part of a broader portfolio of violence prevention strategies available to policy makers and practitioners
Paravasation with cyclophosphamide - Case report of tissue necrosis in a patient with primary breast cancer
Background: Paravasation is a rare but severe complication of treatment with cytotoxic agents. Some anticancer drugs are considered to be of high toxicity (vesicant), some are merely irritant, and some are regarded as nearly non-toxic to healthy tissue as is the case with cyclophosphamide. Case Report: In this report, we present the first case of severe tissue damage caused by a paravasation of cyclophosphamide in a breast cancer patient receiving chemotherapy. Conclusion: Therefore, every attending oncological physician should be aware of the possibility of severe tissue damage as a consequence of cyclophosphamide paravasation
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