5 research outputs found

    Facility Location in Evolving Metrics

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    Understanding the dynamics of evolving social or infrastructure networks is a challenge in applied areas such as epidemiology, viral marketing, or urban planning. During the past decade, data has been collected on such networks but has yet to be fully analyzed. We propose to use information on the dynamics of the data to find stable partitions of the network into groups. For that purpose, we introduce a time-dependent, dynamic version of the facility location problem, that includes a switching cost when a client's assignment changes from one facility to another. This might provide a better representation of an evolving network, emphasizing the abrupt change of relationships between subjects rather than the continuous evolution of the underlying network. We show that in realistic examples this model yields indeed better fitting solutions than optimizing every snapshot independently. We present an O(lognT)O(\log nT)-approximation algorithm and a matching hardness result, where nn is the number of clients and TT the number of time steps. We also give an other algorithms with approximation ratio O(lognT)O(\log nT) for the variant where one pays at each time step (leasing) for each open facility

    Quasispecies Spatial Models for RNA Viruses with Different Replication Modes and Infection Strategies

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    Empirical observations and theoretical studies suggest that viruses may use different replication strategies to amplify their genomes, which impact the dynamics of mutation accumulation in viral populations and therefore, their fitness and virulence. Similarly, during natural infections, viruses replicate and infect cells that are rarely in suspension but spatially organized. Surprisingly, most quasispecies models of virus replication have ignored these two phenomena. In order to study these two viral characteristics, we have developed stochastic cellular automata models that simulate two different modes of replication (geometric vs stamping machine) for quasispecies replicating and spreading on a two-dimensional space. Furthermore, we explored these two replication models considering epistatic fitness landscapes (antagonistic vs synergistic) and different scenarios for cell-to-cell spread, one with free superinfection and another with superinfection inhibition. We found that the master sequences for populations replicating geometrically and with antagonistic fitness effects vanished at low critical mutation rates. By contrast, the highest critical mutation rate was observed for populations replicating geometrically but with a synergistic fitness landscape. Our simulations also showed that for stamping machine replication and antagonistic epistasis, a combination that appears to be common among plant viruses, populations further increased their robustness by inhibiting superinfection. We have also shown that the mode of replication strongly influenced the linkage between viral loci, which rapidly reached linkage equilibrium at increasing mutations for geometric replication. We also found that the strategy that minimized the time required to spread over the whole space was the stamping machine with antagonistic epistasis among mutations. Finally, our simulations revealed that the multiplicity of infection fluctuated but generically increased along time
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