588 research outputs found
ΠΠΎΠ½ΡΠ΅ΠΏΡΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ ΠΏΡΠΈΠ½ΡΡΠΈΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎ Π²ΡΠ±ΠΎΡΠ΅ ΠΏΠΎΡΡΠ°Π²ΡΠΈΠΊΠ° Π½Π° ΠΌΠ΅ΡΠ°Π»Π»ΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΈ
ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΠΉ ΠΏΠΎΠ΄Ρ ΠΎΠ΄ ΠΏΡΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ Π²ΡΠ±ΠΎΡΠ° ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π±ΠΎΡΡΠ±Ρ Ρ ΠΊΠΎΡΡΠΎΠ·ΠΈΠ΅ΠΉ Π½Π° ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡΡ ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ
Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π·Π°ΡΠΈΡΡ Π²Π½ΡΡΡΠΈΡΠΊΠ²Π°ΠΆΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΠΎΡΡΠ΄ΠΎΠ²Π°Π½ΠΈΡ ΠΎΡ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ, Π²ΡΠ·Π²Π°Π½Π½ΡΡ
ΠΊΠΎΡΡΠΎΠ·ΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ Π½Π° ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡΡ
ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ.
Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»Π° ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΠΎ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΡΠ΅ΡΠ΅ΠΏΡΡΡ (ΠΏΠΎ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅ΠΌΡ Π²Π΅ΡΠ΅ΡΡΠ²Ρ) ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² ΠΊΠΎΡΡΠΎΠ·ΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΏΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π±ΠΎΠ»Π΅Π΅ ΡΠΎΠ²Π΅ΡΡΠ΅Π½Π½ΡΡ
ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ². ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΠΈ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠΈΡ
ΠΈΠΌ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ², ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡΠΈΡ
ΡΡ Π΄Π»Ρ Π±ΠΎΡΡΠ±Ρ Ρ ΠΊΠΎΡΡΠΎΠ·ΠΈΠ΅ΠΉ Π½Π° ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΡΡ
ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ.
Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΊΠΎΡΡΠΎΠ·ΠΈΠΎΠ½Π½ΠΎΡΡΠΎΠΉΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ².
ΠΠ±Π»Π°ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ: ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΉ ΡΠΎΠ½Π΄ ΡΠΊΠ²Π°ΠΆΠΈΠ½ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΠ°ΠΏΠ°Π΄Π½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ.The purpose of the study is to analyze methods and technologies for protecting downhole equipment from complications caused by corrosion activity in the fields of Western Siberia.
In the course of the study, the classification of modern formulations (by active substance) of corrosion inhibitors, as well as the prospects for the use of more advanced reagents, was considered in detail. The analysis of technologies and accompanying chemical reagents used to combat corrosion in the fields of Western Siberia is carried out.
The study revealed the positive effects of various technologies, namely inhibition and corrosion-resistant materials.
Field of application: complicated well stock of Western Siberia fields
Cytochrome c is an oxidative stressβactivated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the sn-1 vinyl ether linkage
12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2Ξ³ knockout
ΠΠ΅ΠΆΠΊΡΠ»ΡΡΡΡΠ½Π°Ρ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΡ ΠΈ Π΅Π΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π² Π΄Π΅Π»ΠΎΠ²ΠΎΠΉ ΡΡΠ΅Π΄Π΅
Distinct genetic architectures and environmental factors associate with host response to the Ξ³2-herpesvirus infections
Kaposiβs sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is insufficient to cause disease, suggests other co-factors are involved. Here we present epidemiological analysis and genome-wide association study (GWAS) in 4365 individuals from an African population cohort, to assess the influence of host genetic and non-genetic factors on virus antibody responses. EBV/KSHV co-infection (ORβ=β5.71(1.58β7.12)), HIV positivity (ORβ=β2.22(1.32β3.73)) and living in a more rural area (ORβ=β1.38(1.01β1.89)) are strongly associated with immunogenicity. GWAS reveals associations with KSHV antibody response in the HLA-B/C region (pβ=β6.64βΓβ10β09). For EBV, associations are identified for VCA (rs71542439, pβ=β1.15βΓβ10β12). Human leucocyte antigen (HLA) and trans-ancestry fine-mapping substantiate that distinct variants in HLA-DQA1 (pβ=β5.24βΓβ10β44) are driving associations for EBNA-1 in Africa. This study highlights complex interactions between KSHV and EBV, in addition to distinct genetic architectures resulting in important differences in pathogenesis and transmission
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Pathways to Coastal Resiliency: The Adaptive Gradients Framework
Current and future climate-related coastal impacts such as catastrophic and repetitive flooding, hurricane intensity, and sea level rise necessitate a new approach to developing and managing coastal infrastructure. Traditional βhardβ or βgreyβ engineering solutions are proving both expensive and inflexible in the face of a rapidly changing coastal environment. Hybrid solutions that incorporate natural, nature-based, structural, and non-structural features may better achieve a broad set of goals such as ecological enhancement, long-term adaptation, and social benefits, but broad consideration and uptake of these approaches has been slow. One barrier to the widespread implementation of hybrid solutions is the lack of a relatively quick but holistic evaluation framework that places these broader environmental and societal goals on equal footing with the more traditional goal of exposure reduction. To respond to this need, the Adaptive Gradients Framework was developed and pilot-tested as a qualitative, flexible, and collaborative process guide for organizations to understand, evaluate, and potentially select more diverse kinds of infrastructural responses. These responses would ideally include natural, nature-based, and regulatory/cultural approaches, as well as hybrid designs combining multiple approaches. It enables rapid expert review of project designs based on eight metrics called βgradientsβ, which include exposure reduction, cost efficiency, institutional capacity, ecological enhancement, adaptation over time, greenhouse gas reduction, participatory process, and social benefits. The framework was conceptualized and developed in three phases: relevant factors and barriers were collected from practitioners and experts by survey; these factors were ranked by importance and used to develop the initial framework; several case studies were iteratively evaluated using this technique; and the framework was finalized for implementation. The article presents the framework and a pilot test of its application, along with resources that would enable wider application of the framework by practitioners and theorists
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