Performance of a large limited streamer tube cell in drift mode

The performance of a large (3x3 $cm^2$) streamer tube cell in drift mode is shown. The detector space resolution has been studied using cosmic muons crossing an high precision silicon telescope. The experimental results are compared with a GARFIELD simulation.Comment: 18 pages, 7 figures. Accepted by Nucl. Instr. and Methods

Mode I fatigue limit of notched structures: A deeper insight into Finite Fracture Mechanics

In the present contribution, the coupled stress-energy criterion of Finite Fracture Mechanics (FFM) is applied to assess the fatigue limit of structures weakened by sharp V- and U-notches and subjected to mode I loading conditions. The FFM is a critical-distance-based approach whose implementation requires the knowledge of two material properties, namely the plain material fatigue limit and the threshold value of the stress intensity factor (SIF) range for the fatigue crack growth of long cracks. However, the FFM critical distance is a structural parameter, being a function not only of the material but also of the geometry of the notched component. Experimental notch fatigue results taken from the literature and referred to a variety of materials and geometrical configurations are compared with FFM theoretical estimations, obtained through simple semi-analytical relationships. The case of semi-circular edge notches is also dealt with

Misalignment factors to affect the fatigue of welded load-carrying joints

To assess the effects of misalignment on the weld fatigue, we present experimental fatigue test results of load- carrying cruciform joints which are subjected to axial variable amplitude loading. The welds were produced from steel AH36 grade and fatigue strength improved by high-frequently mechanical impact treatment. We identify several misalignment factors affecting the fatigue by considering the real and reference welded joint geometries. Our methodology includes proposals for the empirical calibration functions and local stress analyses by using the Structural Hot Spot Stress, Effective Notch Stress and Peak Stress Method. Additionally, we apply our methodology to other sixteen data sets which are extracted from the literature for load-carrying cruciform and butt welded joints subjected to constant amplitude loading. Finally, we present the resultant calibration functions with respect to corresponding fatigue test data

Fatigue strength of austempered ductile iron-to-steel dissimilar arc-welded joints

Nowadays, the use of different classes of materials in the same structure is increased to keep pace with innovation and high structural performances. In this context, structural components made of different materials need to be joined together and a possible solution is given by arc welding. Dissimilar welded joints must often be able to withstand fatigue loads; however, Design Standards provide fatigue strength categories only for homogeneous welded joints. The aim of the present paper is to compare the fatigue behaviour of EN-GJS-1050 austempered ductile iron-to-S355J2 steel dissimilar joints to the categories of the corresponding homogeneous steel welded joints, as suggested in International Standards and Recommendations. For this purpose, experimental fatigue tests were performed on a selection of dissimilar welded details. First, the microstructure was identified by metallographic analysis; micro-hardness measurements were collected and residual stress profiles were obtained by using the X-ray diffraction technique on a selection of joints. Misalignments were quantified for all specimens. Then, experimental fatigue tests have been performed on a number of joint geometries subject to axial or bending fatigue loadings and tested in the as-welded conditions. The fracture surfaces of the joints have been analysed to locate fatigue crack nucleation sites

Postprandial kinetics of digestive function in rainbow trout (Oncorhynchus mykiss ): genes expression, enzymatic activity and blood biochemistry as a practical tool for nutritional studies

Postprandial kinetics of genes expression of gastric (chitinase, pepsinogen) and intestinal (alkaline phosphatase, maltase) digestive enzymes and nutrient transporters (peptide transporter 1, sodium-glucose transporter 1), Brush Border Membrane (BBM) enzymes activity (alkaline phosphatase, leucine aminopeptidase, maltase, saccharase) and blood biochemistry (triglycerides, cholesterol, protein, albumin, glucose, amino acids) through NMR spectroscopy, were investigated in rainbow trout (Oncorhynchus mykiss) fed a commercial aquafeed. For this purpose, fish were starved 72 h and digestive tract and blood were sampled before the meal and at 1.5, 3, 6, 9, 12, and 24 h after feeding (T0, T1.5, T3, T6, T9, T12 and T24). The postprandial kinetic showed that the expression of the genes involved in digestion and nutrient transport, the activity of BBM enzymes, and the presence of metabolites in blood were stimulated in different ways by the presence of feed in the digestive tract. The expression of most genes peaked 3 h after meal except gastric pepsinogen and maltase in distal intestine that peaked at T9 and T12, respectively. The activity of BBM enzymes were stimulated differently based on the intestine tract. The plasma proteins level increased from T1.5 until T9, while the other blood parameters unvariated during the postprandial period. This study supplied useful information about the physiological effects a single meal as a potential tool for planning nutritional studies involving the digestive functions

Some relationships between the peak stresses and the local strain energy density for cracks subjected to mixed-mode (I+II) loading

In this work, a link between the averaged strain energy density (SED) approach and the peak stress method in the case of cracks subjected to mixed mode (I+II) loading has been investigated. Some closed-form expressions of the strain energy density, averaged in a volume of radius R0, as function of the Stress Intensity Factors are provided for plane strain conditions under mixed mode I+II loadings, the material being thought of as isotropic and linear elastic.On the basis of the peak stress method (PSM) some expressions useful to estimate the mode I and mode IIstress intensity factors (SIFs) have been recently derived. These relationships take advantage of the elastic peakstresses from FE analyses carried out by using a given mesh pattern where the element size and type are keptconstants. The evaluation of the SIFs from a numerical analysis of the local stress field usually requires veryrefined meshes and then large computational effort. The usefulness of the PSM-based expressions is that (i)only the elastic peak stresses numerically evaluated at the crack tip are needed and not a set of stress–distancedata; (ii) the employed meshes are rather coarse if compared to those necessary for the evaluation of the wholelocal stress field.By substituting the PSM-based relationships in the closed-form expressions of the averaged SED it appears thatthe latter can be directly estimated by means of the elastic peak stresses evaluated at the crack tip.Several FE analyses have been carried out on cracked plates subjected to tension loading considering differentgeometrical combinations, varying the length 2a and the inclination ? of the crack (i.e. the mode mixity) as wellas the size d of the adopted finite elements, with the aim to evaluate the local SED and the elastic peak stresscomponents ?peak and ?peak. In all cases the numerical values of the SED derived from the FE analyses have been compared with those analytically obtained by using the expressions for the SED based on the elastic peakstresses, in order to verify the range of applicability of the proposed relationships

High resolution pixel detectors for e+e- linear colliders

The physics goals at the future e+e- linear collider require high performance vertexing and impact parameter resolution. Two possible technologies for the vertex detector of an experimental apparatus are outlined in the paper: an evolution of the Hybrid Pixel Sensors already used in high energy physics experiments and a new detector concept based on the monolithic CMOS sensors.Comment: 8 pages, to appear on the Proceedings of the International Workshop on Linear Colliders LCWS99, Sitges (Spain), April 28 - May 5, 199

Human adipose-derived stromal cells transplantation prolongs reproductive lifespan on mouse models of mild and severe premature ovarian insufficiency

Background Although recent studies have investigated the ability of Mesenchymal Stromal Cells (MSCs) to alleviate short-term ovarian damage in animal models of chemotherapy-induced Premature Ovarian Insufficiency (POI), no data are available on reproductive lifespan recovery, especially in a severe POI condition. For this reason, we investigated the potential of MSCs isolated from human adipose tissue (hASCs), since they are easy to harvest and abundant, in ameliorating the length and performance of reproductive life in both mild and severe chemotherapy-induced murine POI models. Methods Mild and severe POI models were established by intraperitoneally administering a light (12 mg/kg busulfan + 120 mg/kg cyclophosphamide) or heavy (30 mg/kg busulfan + 120 mg/kg cyclophosphamide) dose of chemotherapy, respectively, in CD1 mice. In both cases, a week later, 1 × 106 hASCs were transplanted systemically through the tail vein. After four additional weeks, some females were sacrificed to collect ovaries for morphological evaluation. H&E staining was performed to assess stroma alteration and to count follicle numbers; immunofluorescence staining for αSMA was used to analyse vascularization. Of the remaining females, some were mated after superovulation to collect 2-cell embryos in order to evaluate their pre-implantation developmental capacity in vitro, while others were naturally mated to monitor litters and reproductive lifespan length. F1 litters’ weight, ovaries and reproductive lifespan were also analysed. Results hASC transplantation alleviated ovarian weight loss and size decrease and reduced alterations on ovarian stroma and vasculature, concurrently preventing the progressive follicle stockpile depletion caused by chemotherapy. These effects were associated with the preservation of the oocyte competence to develop into blastocyst in vitro and, more interestingly, with a significant decrease of chemotherapy-induced POI features, like shortness of reproductive lifespan, reduced number of litters and longer time to plug (the latter only presented in the severe POI model). Conclusion Human ASC transplantation was able to significantly reduce all the alterations induced by the chemotherapeutic treatment, while improving oocyte quality and prolonging reproductive functions, thus counteracting infertility. These results, strengthened by the use of an outbred model, support the potential applications of hASCs in women with POI, nowadays mainly induced by anticancer therapies

The combined cartilage growth – calcification patterns in the wing-fins of Rajidae (Chondrichthyes): A divergent model from endochondral ossification of tetrapods

The relationship between cartilage growth – mineralization patterns were studied in adult Rajidae with X-ray morphology/morphometry, undecalcified resin-embedded, heat-deproteinated histology and scanning electron microscopy. Morphometry of the wing-fins, nine central rays of the youngest and oldest specimens documented a significant decrement of radials mean length between inner, middle and outer zones, but without a regular progression along the ray. This suggests that single radial length growth is regulated in such a way to align inter-radial joints parallel to the wing metapterygia curvature. Trans-illumination and heat-deproteination techniques showed polygonal and cylindrical morphotypes of tesserae, whose aligned pattern ranged from mono-columnar, bi-columnar, and multi-columnar up to the crustal-like layout. Histology of tessellated cartilage allowed to identify of zones of the incoming mineral deposition characterized by enhanced duplication rate of chondrocytes with the formation of isogenic groups, whose morphology and topography suggested a relationship with the impending formation of the radials calcified column. The morphotype and layout of radial tesserae were related to mechanical demands (stiffening) and the size/mass of the radial cartilage body. The cartilage calcification pattern of the batoids model shares several morphological features with tetrapods' endochondral ossification, that is, (chondrocytes' high duplication rate, alignment in rows, increased volume of chondrocyte lacunae), but without the typical geometry of the metaphyseal growth plates

A link between the peak stresses and the averaged strain energy density for cracks under mixed-mode (I+II) loading

In this work, a link between the averaged strain energy density (SED) approach and the peak stressmethod in the case of cracks subjected to mixed mode (I+II) loading has been investigated. Some closed-formexpressions of the strain energy density, averaged in a volume of radius R0, as function of the stress intensityfactors are provided for plane strain conditions under mixed mode I+II loadings.On the basis of the peak stress method (PSM) some expressions useful to estimate the mode I and mode IIstress intensity factors (SIFs) have been recently derived. These relationships take advantage of the elastic peakstresses from FE analyses carried out by using a given mesh pattern where the element size and type are keptconstants. The evaluation of the SIFs from a numerical analysis of the local stress field usually requires veryrefined meshes and then large computational effort. The usefulness of the PSM-based expressions is that (i)only the elastic peak stresses numerically evaluated at the crack tip are needed and not a set of stress–distancedata; (ii) the employed meshes are rather coarse if compared to those necessary for the evaluation of the wholelocal stress field.By substituting the PSM-based relationships in the closed-form expressions of the averaged SED it appears thatthe latter can be directly estimated by means of the elastic peak stresses evaluated at the crack tip.Several FE analyses have been carried out on cracked plates subjected to tension loading considering differentgeometrical combinations, varying the length 2a and the inclination ? of the crack (i.e. the mode mixity) as wellas the size d of the adopted finite elements, with the aim to evaluate the local SED and the elastic peak stresscomponents ?peak and ?peak. In all cases the numerical values of the SED derived from the FE analyses have been compared with those analytically obtained by using the expressions for the SED based on the elastic peakstresses, in order to verify the range of applicability of the proposed relationships