The role of difluprednate ophthalmic emulsion in clinical practice

The mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agents effectively address inflammation, they are not without their risks, including ocular hypertension and acceleration of cataract formation. The most notorious culprits are the strong steroids, such as prednisolone acetate and betamethasone. This review aims to cover the biochemistry and drug development of difluprednate, a novel synthetic strong steroid emulsion. In vivo pharmacokinetics as well as ocular distribution and metabolism are discussed, followed by a comprehensive summary of phase I, II, and III clinical trials evaluating safety and efficacy in patients suffering from postoperative inflammation or anterior uveitis. The objective is to provide an increased familiarity with this newly approved medication as a welcome addition to the ophthalmologist’s armamentarium

Addendum: "The Dynamics of M15: Observations of the Velocity Dispersion Profile and Fokker-Planck Models" (ApJ, 481, 267 [1997])

It has recently come to our attention that there are axis scale errors in three of the figures of Dull et al. (1997, hereafter D97). D97 presented Fokker-Planck models for the collapsed-core globular cluster M15 that include a dense, centrally concentrated population of neutron stars and massive white dwarfs, but do not include a central black hole. In this Addendum, we present corrected versions of Figures 9, 10, and 12, and an expanded version of Figure 6. This latter figure, which shows the full run of the velocity dispersion profile, indicates that the D97 model predictions are in good agreement with the moderately rising HST-STIS velocity dispersion profile for M15 reported by Gerssen et al. (2002, astro-ph/0209315). Thus, a central black hole is not required to fit the new STIS velocity measurements, provided that there is a sufficient population of neutron stars and massive white dwarfs. This conclusion is consistent with the findings of Gerssen et al. (2002, astro-ph/0210158), based on a reapplication of their Jeans equation analysis using the corrected mass-to-light profile (Figure 12) for the D97 models.Comment: 4 pages, 4 figures, submitted to Ap

A Dynamical Study of the Black Hole X-ray Binary Nova Muscae 1991

We present a dynamical study of the Galactic black hole binary system Nova Muscae 1991 (GS/GRS 1124-683). We utilize 72 high resolution Magellan Echellette (MagE) spectra and 72 strictly simultaneous V-band photometric observations; the simultaneity is a unique and crucial feature of this dynamical study. The data were taken on two consecutive nights and cover the full 10.4-hour orbital cycle. The radial velocities of the secondary star are determined by cross-correlating the object spectra with the best-match template spectrum obtained using the same instrument configuration. Based on our independent analysis of five orders of the echellette spectrum, the semi-amplitude of the radial velocity of the secondary is measured to be K_2 = 406.8+/-2.7 km/s, which is consistent with previous work, while the uncertainty is reduced by a factor of 3. The corresponding mass function is f(M) = 3.02+/-0.06 M_\odot. We have also obtained an accurate measurement of the rotational broadening of the stellar absorption lines (v sin i = 85.0+/-2.6 km/s) and hence the mass ratio of the system q = 0.079+/-0.007. Finally, we have measured the spectrum of the non-stellar component of emission that veils the spectrum of the secondary. In a future paper, we will use our veiling-corrected spectrum of the secondary and accurate values of K_2 and q to model multi-color light curves and determine the systemic inclination and the mass of the black hole.Comment: ApJ accepted version; minor revision; added a subsection about systematic uncertaintie

Optical identification of the companion to PSR J1911-5958A, the pulsar binary in the outskirts of NGC 6752

We report on the identification of the optical counterpart of the binary millisecond pulsar PSR J1911-5958A, located in the outskirts of the globular cluster NGC 6752. At the position of the pulsar we find an object with V=22.08, B-V=0.38, U-B=-0.49. The object is blue with respect to the cluster main sequence by 0.8 magnitudes in B-V. We argue that the object is the white dwarf companion of the pulsar. Comparison with white dwarf cooling models shows that this magnitude and colors are consistent with a low-mass white dwarf at the distance of NGC 6752. If associated with NGC 6752, the white dwarf is relatively young, <2 Gyr, which sets constraints on the formation of the binary and its ejection from the core of the globular cluster.Comment: Accepted for publication in A&A Letters (September 1st, 2003

A Sequence of Declining Outbursts from GX339-4

The flux and spectrum of the black hole candidate GX339-4 has been monitored by the Burst and Transient Source Experiment (BATSE) on the Compton Gamma-ray Observatory (CGRO) since the observatory became operational in May 1991. Between the summer of 1991 and the fall of 1996, eight outbursts from GX339-4 were observed. The history of these outbursts is one of declining fluence or total energy release, as well as a shortening of the time between outbursts. A rough linear correlation exists between the fluence emitted during an outburst and the time elapsed between the end of the previous outburst and the beginning of the current one. The peak flux is also roughly linearly correlated with outburst fluence. The lightcurves of the earlier, more intense, outbursts (except for the second one) can be modeled by a fast exponential (time constant ~ 10 days) followed by a slower exponential (~ 100 days) on the rise and a fast exponential decay (~ 5 days) on the fall. The later, weaker, outbursts are modeled with a single rising time constant (~ 20 days) and a longer decay on the fall (~ 50 days). An exponential model gives a marginally better fit than a power law to the rise/decay profiles. GX339-4 is a unique source in having more frequent outbursts than other low mass x-ray binary black hole candidates. These observations can be used to constrain models of the behavior of the accretion disk surrounding the compact object.Comment: Accepted for Publication in the Astrophysical Journal Letters, AASTE

Multiwavelength Observations of GX 339-4 in 1996. III. Keck Spectroscopy

As part of our multiwavelength campaign of observations of GX 339-4 in 1996 we present our Keck spectroscopy performed on May 12 UT. At this time, neither the ASM on the RXTE nor BATSE on the CGRO detected the source. The optical emission was still dominated by the accretion disk with V approximately 17 mag. The dominant emission line is H alpha, and for the first time we are able to resolve a double peaked profile. The peak separation Delta v = 370 +/- 40 km/s. Double peaked H alpha emission lines have been seen in the quiescent optical counterparts of many black hole X-ray novae. However, we find that the peak separation is significantly smaller in GX 339-4, implying that the optical emission comes from a larger radius than in the novae. The H alpha emission line may be more akin to the one in Cygnus X-1, where it is very difficult to determine if the line is intrinsically double peaked because absorption and emission lines from the companion star dominate.Comment: Submitted to Astrophysical Journal. 10 pages. 2 figure

A Catalog of Transient X-ray Sources in M31

From October 1999 to August 2002, 45 transient X-ray sources were detected in M31 by Chandra and XMM-Newton. We have performed spectral analysis of all XMM-Newton and Chandra ACIS detections of these sources, as well as flux measurements of Chandra HRC detections. The result is absorption-corrected X-ray lightcurves for these sources covering this 2.8 year period, along with spectral parameters for several epochs of the outbursts of most of the transient sources. We supply a catalog of the locations, outburst dates, peak observed luminosities, decay time estimates, and spectral properties of the transient sources, and we discuss similarities with Galactic X-ray novae. Duty cycle estimates are possible for 8 of the transients and range from 40% to 2%; upper limits to the duty cycles are estimated for an additional 15 transients and cover a similar range. We find 5 transients which have rapid decay times and may be ultra-compact X-ray binaries. Spectra of three of the transients suggest they may be faint Galactic foreground sources. If even one is a foreground source, this suggests a surface density of faint transient X-ray sources of >~1 deg$^{-2}$.Comment: 63 pages, 22 figures, 3 tables, accepted for publication in Ap

X-ray Spectroscopy of Candidate Ultracompact X-ray Binaries

We present high-resolution spectroscopy of the neutron star/low-mass X-ray binaries (LMXBs) 4U 1850-087 and 4U 0513-40 as part of our continuing study of known and candidate ultracompact binaries. The LMXB 4U 1850-087 is one of four systems in which we had previously inferred an unusual Ne/O ratio in the absorption along the line of sight, most likely from material local to the binaries. However, our recent Chandra X-ray Observatory LETGS spectrum of 4U 1850-087 finds a Ne/O ratio by number of 0.22+/-0.05, smaller than previously measured and consistent with the expected interstellar value. We propose that variations in the Ne/O ratio due to source variability, as previously observed in these sources, can explain the difference between the low- and high-resolution spectral results for 4U 1850-087. Our XMM-Newton RGS observation of 4U 0513-40 also shows no unusual abundance ratios in the absorption along the line of sight. We also present spectral results from a third candidate ultracompact binary, 4U 1822-000, whose spectrum is well fit by an absorbed power-law + blackbody model with absorption consistent with the expected interstellar value. Finally, we present the non-detection of a fourth candidate ultracompact binary, 4U 1905+000, with an upper limit on the source luminosity of < 1 x 10^{32} erg s^{-1}. Using archival data, we show that the source has entered an extended quiescent state.Comment: 8 pages, 3 figures, accepted for publication to the Astrophysical Journa

The Temperature and Cooling Age of the White-Dwarf Companion to the Millisecond Pulsar PSR B1855+09

We report on Keck and {\em Hubble Space Telescope} observations of the binary millisecond pulsar PSR B1855+09. We detect its white-dwarf companion and measure \mv=25.90\pm0.12 and \mi=24.19\pm0.11 (Vega system). From the reddening-corrected color, (\mv-\mi)_0=1.06\pm0.21, we infer a temperature \Teff=4800\pm800 K. The white-dwarf mass is known accurately from measurements of the Shapiro delay of the pulsar signal, \Mcomp=0.258^{+0.028}_{-0.016} \Msun. Hence, given a cooling model, one can use the measured temperature to determine the cooling age. The main uncertainty in the cooling models for such low-mass white dwarfs is the amount of residual nuclear burning, which is set by the thickness of the hydrogen layer surrounding the helium core. From the properties of similar systems, it has been inferred that helium white dwarfs form with thick hydrogen layers, with mass \simgt3\times10^{-3} \Msun, which leads to significant additional heating. This is consistent with expectations from simple evolutionary models of the preceding binary evolution. For PSR B1855+09, though, such models lead to a cooling age of $\sim10$Gyr, which is twice the spin-down age of the pulsar. It could be that the spin-down age were incorrect, which would call the standard vacuum dipole braking model into question. For two other pulsar companions, however, ages well over 10 Gyr are inferred, indicating that the problem may lie with the cooling models. There is no age discrepancy for models in which the white dwarfs are formed with thinner hydrogen layers (\simlt3\times10^{-4} \Msun).Comment: 7 pages, 1 figure, aas4pp2.sty. Accepted for publication in ApJ