Damaged ureter detected on a bone scan

WOS: 000166434000021PubMed ID: 11201483

Reproducibility of left ventricular ejection fraction calculated from gated spect

WOS: 000202967400717

Role of technetium-99m N,N-ethylenedicysteine renal scintigraphy in the evaluation of differential renal function and cortical defects

PubMedID: 16495730PURPOSE: This study was performed to evaluate the effectiveness of technetium-99m N,N-ethylenedicysteine (Tc-99m EC) in comparison to technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) scintigraphy. Differential renal function (DRF) was calculated by both methods and the cortical-phase images of dynamic Tc-99m EC scintigraphy were evaluated for parenchymal defects. MATERIALS AND METHODS: A total of 62 patients with various kidney disorders ranging in age from 1 to 44 years underwent both Tc-99m DMSA and Tc-99m EC scintigraphy. Tc-99m EC summed images of the cortical phase and Tc-99m DMSA images were evaluated visually and quantitatively. Visual analysis was used to define renal parenchymal abnormalities. Quantitative analysis was used in the calculation of DRF. The Tc-99m DMSA scan was taken as the gold standard, and the summed Tc-99m EC scan findings were compared against it. RESULTS: The images obtained with Tc-99m DMSA and Tc-99m EC scintigraphy revealed 99 and 97 focal defects, respectively. The 2 renal parenchyma defects located in the ventral middle sections remained undetected with Tc-99m EC scintigraphy. DRF of the kidneys in each patient was compared using both radiopharmaceuticals. Highly positive correlation between the differential function of these 2 investigations was found (R = 0.91, P = 0.001). The values of mean DRF of the left kidney on Tc-99m EC and Tc-99m DMSA images were 45.8 ± 19.1 and 45.0 ± 20.4, respectively. There were no significant differences (P > 0.05). CONCLUSION: This study suggests that although Tc-99m DMSA scintigraphy remains the gold standard method for evaluating parenchymal abnormalities, Tc-99m EC scintigraphy can be a reliable single-modality study to evaluate renal cortical defects, DRF, perfusion, drainage of the urinary system, and indirect evidence of vesicoureteric reflux with the added advantage of low radiation exposure to the patient. Copyright © 2006 by Lippincott Williams & Wilkins

Demonstration of vesicorectal fistula on renal scan

PubMedID: 15965333The main purpose of renal scintigraphy in pediatric patients is the quantitation of renal function, which is not easily obtained by the other diagnostic modalities. Sometimes it also provides valuable anatomic as well as functional information about the urinary tract. We present a case with a vesicorectal fistula to describe the use of Tc-99m DTPA diuretic renography in the diagnosis of a vesicorectal fistula and to localize its level. Copyright © 2005 by Lippincott Williams & Wilkins

Effectiveness of diuretic injection on the measurement of differential renal function using Tc-99m DMSA in patients with a dilated renal pelvis

PubMedID: 16237293Aim: The aim of this study was to evaluate the effectiveness of diuretic injection for the measurement of differential renal function (DRF) with technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) scintigraphy in patients with a dilated pelvis. Materials and Methods: A total of 46 patients who were referred for both technetium-99m-L,L-ethylenedicysteine (Tc-99m L,L-EC) and Tc-99m DMSA imaging and found to have a dilated collecting system on Tc-99m EC scintigraphy were studied. Four to 5 hours after intravenous injection of Tc-99m DMSA, imaging was performed in the supine position, and posterior, anterior, left and right lateral, and left and right posterior oblique views were taken. After this study, furosemide was administered intravenously and 30 minutes later, additional images in the anterior and posterior views were obtained. Results: The kidneys were evaluated into 2 groups. Group 1 comprised 12 kidneys that had an obstructive curve pattern on Tc-99m EC scans. Group 2 comprised 34 kidneys that had a nonobstructive dilated renogram curve pattern. DRF of the kidneys in each patient were calculated, and the values obtained from the standard and diuretic DMSA scans were compared with each other for all patients and each group. Considering all the patients, the values of mean DRF on both standard and diuretic DMSA images were 55.4% ± 21.2% and 55.4% ± 21.5%, respectively. There were no significant differences between DRF values of each kidney obtained by the 2 methods. When we compared the DRF values in groups 1 and 2, there were again no significant differences. In group 1, the values of mean DRF on standard and diuretic images were 51.7% ± 13.7% and 51.6% ± 13.9%, respectively, and in group 2, the values of mean DRF were 56.7% ± 23.4% and 56.7% ± 23.6%, respectively. Conclusion: In view of our study, diuretic administration seems to be an unnecessary intervention because it has no effect on the accuracy of DRF measurements using DMSA scintigraphy in patients with a dilated collecting system whether it is obstructed or not. Copyright © 2005 by Lippincott Williams & Wilkins

Tc-99m MIBI uptake in traumatic vertebral fractures and metastatic vertebral lesions: Comparison with Tc-99m MDP

PubMedID: 16644620This study compared technetium-99m-hexakis-2-methoxyisobutyl-isonitrile (Tc-99m MIBI) with technetium-99m methylene diphosphonate (Tc-99m MDP) to determine whether Tc-99m MIBI could distinguish vertebral metastases from traumatic vertebral fractures. Twenty patients with traumatic vertebral fracture (and no malignant disease) and 14 patients with metastatic vertebral lesions were evaluated. Three to 4 hours after intravenous injection of Tc-99m MDP, images of the vertebrae in all patients were obtained. Corresponding Tc-99m MIBI images were acquired within 4 days after the Tc-99m MDP bone images were obtained. Computed tomography and magnetic resonance imaging demonstrated 24 vertebral traumatic fractures and 44 vertebral metastases. On conventional bone scans, Tc-99m MDP activity was increased in 92% of vertebral fractures and in 100% of vertebral metastases. However, on MIBI scans, no abnormal findings were observed in the vertebrae with fracture, although increased activity was seen in 73% of vertebral metastases. In this study, traumatic vertebral fractures tended to display no pathologic increases in Tc-99m MIBI uptake, whereas bone metastases usually appeared with high uptake. In light of the excellent specificity of Tc-99m MIBI scans compared with Tc-99m MDP bone scans, imaging studies that use Tc-99m MIBI scans may play an important complementary role in differentiating vertebral metastases from traumatic vertebral fractures. ©2006 Health Communications Inc

Tc-99m MIBI findings of acute vertebral fractures in traumatic patients: Preliminary results

Annual Congress of the European-Association-of-Nuclear-Medicine -- SEP 04-08, 2004 -- Helsinki, FINLANDWOS: 000223419901180…European Assoc Nucl Me

Evaluation of vascularized graft reconstruction of the mandible with Tc-99m MDP bone scintigraphy

PubMedID: 16615416Aim: The aim of this study was to evaluate the value of bone scintigraphy for the assessment of graft viability following vascularized bone grafts in patients with mandibular reconstruction. Methods: We investigated 16 patients with vascularized grafts from the fibula (13 patients) and iliac crest (3 patients) in the last 8 years. For the follow up of all these patients, Tc-99m MDP bone scintigraphy was performed between 2-10 days postoperatively. SPECT study was included in 5 patients. For the evaluation of the grafts, a six-grade scoring system was used. The grading system was based on a comparison of tracer uptake between graft and the cranium. The uptake was defined as increasing from grade 6 to grade 1. Results: Thirteen of the 16 grafts had an uncomplicated clinical course. Complications in the graft occurred in three patients. In the analysis of planar scintigrams, patients with uncomplicated healing showed increased uptake in 12 of the 13 grafts (grade 1-3) and 1 showed the same level tracer uptake compared to cranium (grade 4). In the failed 3 grafts, decreased uptake was observed (grade 5 and 6). In 5 patients, SPECT was performed in addition to planar imaging. In these patients, 4 of the 5 grafts had an uncomplicated clinical course and 1 had a complicated one. In the analysis of SPECT images, while all the grafts with an uncomplicated clinical course exhibited increased uptake (grade 1-3), the failed graft showed decreased uptake (grade 6). Conclusion: Three-phase bone scintigraphy performed within 10 days after the mandibular reconstruction is a useful tool to monitor the viability and early complications of vascularized mandibular bone grafts. SPECT is also recommended. It may contribute to interpretation of the bone scans and to precise assessment of graft viability

Technetium-99m-MIBI uptake in bone metastases: A comparative study with technetium-99m-MDP

Aim: The purpose of this study was to determine the potential of Tc-99m hexakis-2-methoxyisobutylisonitrile (MIBI) for detection of bone metastases in breast cancer patients in comparison to Tc-99m methylene diphosphonate (MDP) bone scans. Materials and Methods: Tc-99m MIBI and Tc-99m MDP scans were performed in 55 patients with breast cancer and suspected bone metastases. Three to four hours following i.v. injection of 740 MBq (20 mCi) Tc-99m MDP, a total-body study was performed. Spot images of abnormal areas were also taken. Tc-99m MIBI scanning was performed within the same week of obtaining the Tc-99m MDP scans. Acquisition of the Tc-99m MIBI images was begun 1 minute after bolus injection of Tc-99m MIBI. First, lumbar spine and then spot images of pelvis, thorax, and head were acquired for 5 minutes. Following spot images whole-body anterior and posterior images were also obtained. Results: Conventional Tc-99m MDP bone scans showed abnormal skeletal uptake in 276 lesions. Tc-99m MIBI scans showed abnormal skeletal uptake in 120 lesions. Bone metastases were confirmed in 149 lesions by plain radiography, CT, MRI, marrow cytology, or evidence of progressive bone lesions on follow-up Tc-99m MDP. Although all of the metastatic lesions (n: 149) were detected on Tc-99m MDP scans, 120 lesions of the metastatic lesions (120/149 = 80%) were detected on Tc-99m MIBI scans. On the other hand, false-positive findings on Tc-99m MDP scans were quite high; 127 lesions of the 276 lesions were false-positive (127/276 = 46%). There were no false-positive results on Tc-99m MIBI scans. Conclusion: In our study, it has been shown that Tc-99m MIBI scans have relative comparable sensitivity to Tc-99m MDP scans (80% and 100%, respectively) in detecting bone metastases in patients with breast cancer. If we consider the excellent specificity of Tc-99m MIBI scans compared with Tc-99m MDP bone scans, we can conclude that Tc-99m MIBI scans have a very important complementary role in detecting bone metastases. Copyright © 2005 by Lippincott Williams & Wilkins

Thyroid hemiagenesis: a report of three cases and review of the literature

WOS: 000228772200012PubMed ID: 15909495Thyroid hemiagenesis resulting from the failure of embryologic development of one thyroidal lobe is a very rare anomaly. It is usually incidentally discovered during the investigation of accompanying thyroid disorders. Here we report three cases with right lobe agenesis in two patients and left lobe agenesis in one patient. Two of them were hyperthyroid, while the other euthyroid patient had a thyroid mass