Alien Registration- Berube, Alfred G. (Allagash, Aroostook County)

https://digitalmaine.com/alien_docs/32260/thumbnail.jp

The Administrative Code of 1931: William Tudor Gardiner and Government Reform

Welfare reform, downsizing government and making government more efficient are issues that could be taken from some 1990s political candidate\u27s campaign handbook. But they have been longstanding themes in Maine\u27s political history. Administrative reform was a key element in William Tudor Gardiner\u27s two terms as governor from 1929 to 1933. No study of Gardiner\u27s career would be complete without examining the events encompassing the Administrative Code of 1931, a comprehensive reform bill that was intended to change the way Maine government operated. Claude G. Berube earned his Bachelor of Arts degree in history from Saint Anselm College in 1988 and his Master of Arts in history from Northeastern University in 1990. He is currently writing a biography of Governor William Tudor Gardiner. An officer in the U.S. Naval Reserve, he is a native of Lewiston, Maine, and currently resides in Virginia. He would like to thank Miss Margaret Gardiner of Woolwich, for their interviews and permission to review and use material from Gov. Gardiner\u27s personal papers and photographs

A statistical study of transient event motion at geosynchronous orbit

The geosynchronous GOES 5 and GOES 6 satellites frequently observe transient events marked by magnetic field strength increases and bipolar magnetic field signatures lasting several minutes. In this study we report a survey of 87 events observed simultaneously by both GOES spacecraft (for a total of 174 individual observations) from August to December 1984. Events detected in the prenoon sector outnumbered those in the postnoon sector by about a 3 to 1 ratio. The distribution of the events versus local time exhibited a significant prenoon peak like the distribution of magnetic impulse events observed in high-latitude ground magnetometers. A cross-correlation analysis of the two GOES data sets indicated lags that range from 0 to over 2 min, with the majority of the events moving antisunward. The short lags correspond to azimuthal speeds of hundreds of kilometers per second, greater than flow speeds in the magnetosheath, but less than fast mode waves. The short lags may indicate that the events move primarily latitudinally and/or that transient events are seldom localized, but rather occur over extended, if not global, regions. Investigations of event occurrence versus interplanetary magnetic field (IMF) Bz, event motion versus IMF By, and correspondence between upstream plasma data and the events all indicate that pressure pulses are the likely source of many of the events. About 27% of the events with simultaneous solar wind data were preceded by sharp reversals in one or more IMF components, and nearly all of this particular group of events occurred in the dawn sector. This suggests that the pressure pulses may be commonly generated in the foreshock/bow shock region, since the prenoon magnetopause lies generally behind the quasi-parallel bow shock where such pulses are thought to be triggered by IMF discontinuities. Finally, several events in the data set were also observed by the AMPTE/CCE. These are presented as case studies

Global profiles of compressional ultralow frequency wave power at geosynchronous orbit and their response to the solar wind

We investigate the global local-time profiles of compressional wave power in three ultralow frequency (ULF) bands corresponding to Pc3, Pc4, and Pc5 pulsations using magnetic field data from the geosynchronous GOES satellites. The global power profiles of the three frequency bands are studied for low, moderate, and high levels of geomagnetic activity based on the Dst index. We also consider the seasonal variation of the ULF power profiles, as well as the effects of solar wind and interplanetary magnetic field (IMF) parameters. For high geomagnetic activity, we find that the greatest power is associated with compressional Pc5 pulsations in the afternoon sector; for low geomagnetic activity, ULF power levels are consistently highest in the tail region. A summer power minimum in all three frequency bands is observed in our study of seasonal variation, while higher power levels occur around local midnight throughout the year. The enhancement of ULF power by high solar wind velocity and pressure is greater for the lower-frequency waves. Furthermore, solar wind plasma parameters have a significantly greater influence on ULF wave power than IMF parameters like cone angle and northward/southward orientation

Mosaic expression of Atrx in the mouse central nervous system causes memory deficits

The rapid modulation of chromatin organization is thought to play a crucial role in cognitive processes such as memory consolidation. This is supported in part by the dysregulation of many chromatin-remodelling proteins in neurodevelopmental and psychiatric disorders. A key example is ATRX, an X-linked gene commonly mutated in individuals with syndromic and nonsyndromic intellectual disability. The consequences of Atrx inactivation for learning and memory have been difficult to evaluate because of the early lethality of hemizygous-null animals. In this study, we evaluated the outcome of brain-specific Atrx deletion in heterozygous female mice. These mice exhibit a mosaic pattern of ATRX protein expression in the central nervous system attributable to the location of the gene on the X chromosome. Although the hemizygous male mice die soon after birth, heterozygous females survive to adulthood. Body growth is stunted in these animals, and they have low circulating concentrations of insulin growth factor 1. In addition, they are impaired in spatial, contextual fear and novel object recognition memory. Our findings demonstrate that mosaic loss of ATRX expression in the central nervous system leads to endocrine defects and decreased body size and has a negative impact on learning and memory

Dietary calcium and vitamin D intakes in childhood and throughout adulthood and mammographic density in a British birth cohort

We examined the role of dietary calcium and vitamin D intakes in childhood and throughout adulthood in relation to mammographic density using data from a nationally representative cohort of 1161 women followed up since their birth in 1946. Dietary intakes at the age of 4 years were determined by 24-h recalls and at the ages of 36, 43 and 53 years by 5-day food records. After adjusting for known risk factors and confounders, no evidence of a relationship between dietary calcium or vitamin D intakes and mammographic density approximately at the age of 50 years was found, except for a cross-sectional relationship between dietary calcium intake at the age of 53 years and breast density in women who were post-menopausal at the time of mammography, with those in the top fifth of the distribution of calcium intake having a 0.53 s.d. lower percent breast density than those in the lowest fifth (P-value <0.01 for linear trend)

Physiology and evolution of nitrate acquisition in Prochlorococcus

Prochlorococcus is the numerically dominant phototroph in the oligotrophic subtropical ocean and carries out a significant fraction of marine primary productivity. Although field studies have provided evidence for nitrate uptake by Prochlorococcus, little is known about this trait because axenic cultures capable of growth on nitrate have not been available. Additionally, all previously sequenced genomes lacked the genes necessary for nitrate assimilation. Here we introduce three Prochlorococcus strains capable of growth on nitrate and analyze their physiology and genome architecture. We show that the growth of high-light (HL) adapted strains on nitrate is ~17% slower than their growth on ammonium. By analyzing 41 Prochlorococcus genomes, we find that genes for nitrate assimilation have been gained multiple times during the evolution of this group, and can be found in at least three lineages. In low-light adapted strains, nitrate assimilation genes are located in the same genomic context as in marine Synechococcus. These genes are located elsewhere in HL adapted strains and may often exist as a stable genetic acquisition as suggested by the striking degree of similarity in the order, phylogeny and location of these genes in one HL adapted strain and a consensus assembly of environmental Prochlorococcus metagenome sequences. In another HL adapted strain, nitrate utilization genes may have been independently acquired as indicated by adjacent phage mobility elements; these genes are also duplicated with each copy detected in separate genomic islands. These results provide direct evidence for nitrate utilization by Prochlorococcus and illuminate the complex evolutionary history of this trait.Gordon and Betty Moore Foundation (Grant GBMF495)National Science Foundation (U.S.) (Grant OCE-1153588)National Science Foundation (U.S.) (Grant DBI-0424599

Alpha thalassaemia-mental retardation, X linked

X-linked alpha thalassaemia mental retardation (ATR-X) syndrome in males is associated with profound developmental delay, facial dysmorphism, genital abnormalities and alpha thalassaemia. Female carriers are usually physically and intellectually normal. So far, 168 patients have been reported. Language is usually very limited. Seizures occur in about one third of the cases. While many patients are affectionate with their caregivers, some exhibit autistic-like behaviour. Patients present with facial hypotonia and a characteristic mouth. Genital abnormalities are observed in 80% of children and range from undescended testes to ambiguous genitalia. Alpha-thalassaemia is not always present. This syndrome is X-linked recessive and results from mutations in the ATRX gene. This gene encodes the widely expressed ATRX protein. ATRX mutations cause diverse changes in the pattern of DNA methylation at heterochromatic loci but it is not yet known whether this is responsible for the clinical phenotype. The diagnosis can be established by detection of alpha thalassaemia, identification of ATRX gene mutations, ATRX protein studies and X-inactivation studies. Genetic counselling can be offered to families. Management is multidisciplinary: young children must be carefully monitored for gastro-oesophageal reflux as it may cause death. A number of individuals with ATR-X are fit and well in their 30s and 40s